Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Proceedings of the National Academy of Sciences of the United States of America
2025
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41218118/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266130267701249 |
|---|---|
| author | Wu, Christina C N De Luna, Naycari Hairston, Erin Jeffs, Erin D Key, Ashley Adams, Stephen R Advani, Sunil J Gaasterland, Terry Carson, Dennis A Willert, Karl |
| author_facet | Wu, Christina C N De Luna, Naycari Hairston, Erin Jeffs, Erin D Key, Ashley Adams, Stephen R Advani, Sunil J Gaasterland, Terry Carson, Dennis A Willert, Karl Wu, Christina C N De Luna, Naycari Hairston, Erin Jeffs, Erin D Key, Ashley Adams, Stephen R Advani, Sunil J Gaasterland, Terry Carson, Dennis A Willert, Karl |
| collection | PubMed - marine biology |
| contents | FZD7 expression marks mammary tumor-initiating cells. Wu, Christina C N De Luna, Naycari Hairston, Erin Jeffs, Erin D Key, Ashley Adams, Stephen R Advani, Sunil J Gaasterland, Terry Carson, Dennis A Willert, Karl Animals Frizzled Receptors Female Mice Neoplastic Stem Cells Humans Wnt1 Protein Mammary Neoplasms, Experimental Wnt Signaling Pathway Triple Negative Breast Neoplasms Cell Line, Tumor Breast Neoplasms Gene Expression Regulation, Neoplastic Mice, Transgenic Immunoconjugates The WNT signaling pathway has long been implicated in tumorigenesis across multiple cancer types, including breast cancer. However, the complexity arising from the large number of WNTs and their receptors has made it challenging to pinpoint specific components driving tumor development. Using the MMTV- genetically engineered mouse model, which develops mixed-lineage mammary tumors resembling triple-negative breast cancer and composed of both basal and luminal subtypes, we identify the frizzled class receptor 7 (Fzd7) as a key player. Fzd7 is expressed on mammary tumor cells that show enhanced tumorigenic potential in both orthotopic transplantation and tumor organoid assays. Despite the cellular heterogeneity of MMTV- tumors, treatment with a Fzd7-specific antibody-drug conjugate significantly suppresses tumor growth, suggesting that Fzd7-expressing cells are critical drivers of tumor progression. These findings show that Fzd7 marks a population of putative tumor-initiating cells and that targeting Fzd7 offers a promising therapeutic strategy for breast cancer. |
| format | Artículo científico |
| id | pubmed_41218118 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Proceedings of the National Academy of Sciences of the United States of America |
| record_format | pubmed |
| spellingShingle | FZD7 expression marks mammary tumor-initiating cells. Wu, Christina C N De Luna, Naycari Hairston, Erin Jeffs, Erin D Key, Ashley Adams, Stephen R Advani, Sunil J Gaasterland, Terry Carson, Dennis A Willert, Karl Animals Frizzled Receptors Female Mice Neoplastic Stem Cells Humans Wnt1 Protein Mammary Neoplasms, Experimental Wnt Signaling Pathway Triple Negative Breast Neoplasms Cell Line, Tumor Breast Neoplasms Gene Expression Regulation, Neoplastic Mice, Transgenic Immunoconjugates FZD7 expression marks mammary tumor-initiating cells. Wu, Christina C N De Luna, Naycari Hairston, Erin Jeffs, Erin D Key, Ashley Adams, Stephen R Advani, Sunil J Gaasterland, Terry Carson, Dennis A Willert, Karl Animals Frizzled Receptors Female Mice Neoplastic Stem Cells Humans Wnt1 Protein Mammary Neoplasms, Experimental Wnt Signaling Pathway Triple Negative Breast Neoplasms Cell Line, Tumor Breast Neoplasms Gene Expression Regulation, Neoplastic Mice, Transgenic Immunoconjugates The WNT signaling pathway has long been implicated in tumorigenesis across multiple cancer types, including breast cancer. However, the complexity arising from the large number of WNTs and their receptors has made it challenging to pinpoint specific components driving tumor development. Using the MMTV- genetically engineered mouse model, which develops mixed-lineage mammary tumors resembling triple-negative breast cancer and composed of both basal and luminal subtypes, we identify the frizzled class receptor 7 (Fzd7) as a key player. Fzd7 is expressed on mammary tumor cells that show enhanced tumorigenic potential in both orthotopic transplantation and tumor organoid assays. Despite the cellular heterogeneity of MMTV- tumors, treatment with a Fzd7-specific antibody-drug conjugate significantly suppresses tumor growth, suggesting that Fzd7-expressing cells are critical drivers of tumor progression. These findings show that Fzd7 marks a population of putative tumor-initiating cells and that targeting Fzd7 offers a promising therapeutic strategy for breast cancer. |
| title | FZD7 expression marks mammary tumor-initiating cells. |
| topic | Animals Frizzled Receptors Female Mice Neoplastic Stem Cells Humans Wnt1 Protein Mammary Neoplasms, Experimental Wnt Signaling Pathway Triple Negative Breast Neoplasms Cell Line, Tumor Breast Neoplasms Gene Expression Regulation, Neoplastic Mice, Transgenic Immunoconjugates |
| url | https://pubmed.ncbi.nlm.nih.gov/41218118/ |