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Hauptverfasser:	Wahl, Niklas Alexander, Lebrón-Acosta, Naiara, Pérez-Cuevas, Michelle, Hernandez-Mejias, Angel, Leshchiner, Dmitry, Valeriote, Frederick A, Caro-Diaz, Eduardo J E, Horibata, Sachi
Format:	Artículo científico
Sprache:	en
Veröffentlicht:	Scientific reports 2025
Schlagworte:	Humans Biological Products Cell Line, Tumor Antineoplastic Agents Signal Transduction Neoplasms Female Cell Survival
Online-Zugang:	https://pubmed.ncbi.nlm.nih.gov/41225047/
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

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author	Wahl, Niklas Alexander Lebrón-Acosta, Naiara Pérez-Cuevas, Michelle Hernandez-Mejias, Angel Leshchiner, Dmitry Valeriote, Frederick A Caro-Diaz, Eduardo J E Horibata, Sachi
author_facet	Wahl, Niklas Alexander Lebrón-Acosta, Naiara Pérez-Cuevas, Michelle Hernandez-Mejias, Angel Leshchiner, Dmitry Valeriote, Frederick A Caro-Diaz, Eduardo J E Horibata, Sachi Wahl, Niklas Alexander Lebrón-Acosta, Naiara Pérez-Cuevas, Michelle Hernandez-Mejias, Angel Leshchiner, Dmitry Valeriote, Frederick A Caro-Diaz, Eduardo J E Horibata, Sachi
collection	PubMed - marine biology
contents	Majusculamide-o, a simplified marine natural product analog, exhibits potent and specific cancer cell cytotoxicity. Wahl, Niklas Alexander Lebrón-Acosta, Naiara Pérez-Cuevas, Michelle Hernandez-Mejias, Angel Leshchiner, Dmitry Valeriote, Frederick A Caro-Diaz, Eduardo J E Horibata, Sachi Humans Biological Products Cell Line, Tumor Antineoplastic Agents Signal Transduction Neoplasms Female Cell Survival Metastatic solid tumors (e.g., ovary, pancreas, liver, lung, and brain) contribute to a high mortality rate in cancer patients with few therapeutically effective anticancer drugs available for their treatment, highlighting the need to develop agents that target solid tumors. Natural products (NPs) derived from cyanobacteria possess potent anticancer activity, yet most are hard to synthesize and modify to improve therapeutic efficacy. Here, we have efficiently synthesized a simplified analog of the marine NP majusculamide D, majusculamide o (maj-o, 1), that has remarkable potency and selective cytotoxicity towards various metastatic cancer cells. We found that maj-o (1) treatment presents potent cytotoxicity in various cancer cell lines of the ovary (OVCAR3), pancreas (PANC1), brain (U251N), and lung (H125) in a dose-dependent manner, with the least cytotoxic effect towards non-metastatic or primary tumors of the liver (HEPG2) and ovary (OVCAR8). 1 significantly alters gene expression signatures with more treatment time and affects pathways associated with PI3K-Akt signaling and the Hippo pathway. Our finding suggests that maj-o has great potential to serve as a lead compound for the development of novel antineoplastics for solid tumors.
format	Artículo científico
id	pubmed_41225047
institution	PubMed
language	en
publishDate	2025
publisher	Scientific reports
record_format	pubmed
spellingShingle	Majusculamide-o, a simplified marine natural product analog, exhibits potent and specific cancer cell cytotoxicity. Wahl, Niklas Alexander Lebrón-Acosta, Naiara Pérez-Cuevas, Michelle Hernandez-Mejias, Angel Leshchiner, Dmitry Valeriote, Frederick A Caro-Diaz, Eduardo J E Horibata, Sachi Humans Biological Products Cell Line, Tumor Antineoplastic Agents Signal Transduction Neoplasms Female Cell Survival Majusculamide-o, a simplified marine natural product analog, exhibits potent and specific cancer cell cytotoxicity. Wahl, Niklas Alexander Lebrón-Acosta, Naiara Pérez-Cuevas, Michelle Hernandez-Mejias, Angel Leshchiner, Dmitry Valeriote, Frederick A Caro-Diaz, Eduardo J E Horibata, Sachi Humans Biological Products Cell Line, Tumor Antineoplastic Agents Signal Transduction Neoplasms Female Cell Survival Metastatic solid tumors (e.g., ovary, pancreas, liver, lung, and brain) contribute to a high mortality rate in cancer patients with few therapeutically effective anticancer drugs available for their treatment, highlighting the need to develop agents that target solid tumors. Natural products (NPs) derived from cyanobacteria possess potent anticancer activity, yet most are hard to synthesize and modify to improve therapeutic efficacy. Here, we have efficiently synthesized a simplified analog of the marine NP majusculamide D, majusculamide o (maj-o, 1), that has remarkable potency and selective cytotoxicity towards various metastatic cancer cells. We found that maj-o (1) treatment presents potent cytotoxicity in various cancer cell lines of the ovary (OVCAR3), pancreas (PANC1), brain (U251N), and lung (H125) in a dose-dependent manner, with the least cytotoxic effect towards non-metastatic or primary tumors of the liver (HEPG2) and ovary (OVCAR8). 1 significantly alters gene expression signatures with more treatment time and affects pathways associated with PI3K-Akt signaling and the Hippo pathway. Our finding suggests that maj-o has great potential to serve as a lead compound for the development of novel antineoplastics for solid tumors.
title	Majusculamide-o, a simplified marine natural product analog, exhibits potent and specific cancer cell cytotoxicity.
topic	Humans Biological Products Cell Line, Tumor Antineoplastic Agents Signal Transduction Neoplasms Female Cell Survival
url	https://pubmed.ncbi.nlm.nih.gov/41225047/

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