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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of medicinal chemistry
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41229169/ |
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Table of Contents:
- Structure-Directed Optimization of Ebselen Derivatives as Potent NDM-1 Inhibitors Reverses Meropenem Resistance. Guo, Yan Liu, Chenyu Liu, Wandong Zhang, Chen Liu, Zhiying Wan, Shengbiao Xu, Ximing Chen, Sheng Qiu, Jiazhang Isoindoles beta-Lactamases Organoselenium Compounds Microbial Sensitivity Tests Animals beta-Lactamase Inhibitors Structure-Activity Relationship Meropenem Azoles Anti-Bacterial Agents Mice Humans Drug Resistance, Bacterial Escherichia coli "Superbugs" harboring the New Delhi metallo-β-lactamase-1 (NDM-1) have disseminated globally, posing a severe threat to the clinical efficacy of β-lactam antibiotics. Developing NDM-1 inhibitors to restore the efficacy of β-lactam antibiotics against resistant bacteria is critically important. Using ebselen as a lead, we designed and synthesized 59 novel derivatives to develop potent NDM-1 inhibitors. Among them, compound demonstrated the most potent NDM-1 inhibitory activity with an IC value of 1.12 μM. The combination of and Mem reduced the minimum inhibitory concentration (MIC) of Mem by 4-16-fold in NDM-1-producing isolates. Importantly, the combination of and Mem effectively suppressed the bacterial loads in mice. Mechanistically, effectively inhibits the activity of NDM-1 by forming a Se-S covalent bond with the NDM-1 protein. Collectively, these findings confirm that compound is an excellent NDM-1 covalent inhibitor, offering a promising lead compound for addressing bacterial resistance driven by NDM-1.