Sodium alginate/carboxymethyl chitosan hydrogel loading antioxidant peptide YSQLENEFDR accelerates infected wound healing in rat.
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| Format: | Artículo científico |
| Sprache: | en |
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International journal of biological macromolecules
2025
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| author | Wang, Yuqiong Sun, Yuqi Zhang, Shanshan Fang, Shimin Sheng, Wenlong Zhang, Xuanming Li, Peihai Li, Xiaobin Stoika, Rostyslav Wang, Lizhen Duan, Hongdong |
| author_facet | Wang, Yuqiong Sun, Yuqi Zhang, Shanshan Fang, Shimin Sheng, Wenlong Zhang, Xuanming Li, Peihai Li, Xiaobin Stoika, Rostyslav Wang, Lizhen Duan, Hongdong Wang, Yuqiong Sun, Yuqi Zhang, Shanshan Fang, Shimin Sheng, Wenlong Zhang, Xuanming Li, Peihai Li, Xiaobin Stoika, Rostyslav Wang, Lizhen Duan, Hongdong |
| collection | PubMed - marine biology |
| contents | Sodium alginate/carboxymethyl chitosan hydrogel loading antioxidant peptide YSQLENEFDR accelerates infected wound healing in rat. Wang, Yuqiong Sun, Yuqi Zhang, Shanshan Fang, Shimin Sheng, Wenlong Zhang, Xuanming Li, Peihai Li, Xiaobin Stoika, Rostyslav Wang, Lizhen Duan, Hongdong Animals Chitosan Alginates Wound Healing Antioxidants Hydrogels Rats Male Peptides Rats, Sprague-Dawley Wound Infection Bandages Excessive reactive oxygen species (ROS) in wound sites can inhibit re-epithelialization and cause non-healing wounds. Therefore, it is an urgent need to develop antioxidant wound dressings. Herein, we prepared a novel OCP hydrogel containing antioxidant peptide YSQLENEFDR, oxidized sodium alginate, and carboxymethyl chitosan. The hydrogel showed a porous structure and good water swelling property. Conveniently, OCP hydrogel could be injected onto irregular wounds through a syringe. The damaged hydrogel could heal in 10 min without any external influence. The conducted biological studies in vitro showed remarkable biocompatibility and hemocompatibility. In a rat model, OCP hydrogel significantly promoted the healing of bacteria-infected wounds. Histological study of wound tissues showed a reduced inflammation level, newly generated hair follicles, and distinct collagen accumulation. The biomarkers related to angiogenesis and anti-inflammation showed high expression levels. Summarizing, OCP hydrogel is an antioxidant wound dressing with potential for treatment of infected wounds. |
| format | Artículo científico |
| id | pubmed_41241347 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | International journal of biological macromolecules |
| record_format | pubmed |
| spellingShingle | Sodium alginate/carboxymethyl chitosan hydrogel loading antioxidant peptide YSQLENEFDR accelerates infected wound healing in rat. Wang, Yuqiong Sun, Yuqi Zhang, Shanshan Fang, Shimin Sheng, Wenlong Zhang, Xuanming Li, Peihai Li, Xiaobin Stoika, Rostyslav Wang, Lizhen Duan, Hongdong Animals Chitosan Alginates Wound Healing Antioxidants Hydrogels Rats Male Peptides Rats, Sprague-Dawley Wound Infection Bandages Sodium alginate/carboxymethyl chitosan hydrogel loading antioxidant peptide YSQLENEFDR accelerates infected wound healing in rat. Wang, Yuqiong Sun, Yuqi Zhang, Shanshan Fang, Shimin Sheng, Wenlong Zhang, Xuanming Li, Peihai Li, Xiaobin Stoika, Rostyslav Wang, Lizhen Duan, Hongdong Animals Chitosan Alginates Wound Healing Antioxidants Hydrogels Rats Male Peptides Rats, Sprague-Dawley Wound Infection Bandages Excessive reactive oxygen species (ROS) in wound sites can inhibit re-epithelialization and cause non-healing wounds. Therefore, it is an urgent need to develop antioxidant wound dressings. Herein, we prepared a novel OCP hydrogel containing antioxidant peptide YSQLENEFDR, oxidized sodium alginate, and carboxymethyl chitosan. The hydrogel showed a porous structure and good water swelling property. Conveniently, OCP hydrogel could be injected onto irregular wounds through a syringe. The damaged hydrogel could heal in 10 min without any external influence. The conducted biological studies in vitro showed remarkable biocompatibility and hemocompatibility. In a rat model, OCP hydrogel significantly promoted the healing of bacteria-infected wounds. Histological study of wound tissues showed a reduced inflammation level, newly generated hair follicles, and distinct collagen accumulation. The biomarkers related to angiogenesis and anti-inflammation showed high expression levels. Summarizing, OCP hydrogel is an antioxidant wound dressing with potential for treatment of infected wounds. |
| title | Sodium alginate/carboxymethyl chitosan hydrogel loading antioxidant peptide YSQLENEFDR accelerates infected wound healing in rat. |
| topic | Animals Chitosan Alginates Wound Healing Antioxidants Hydrogels Rats Male Peptides Rats, Sprague-Dawley Wound Infection Bandages |
| url | https://pubmed.ncbi.nlm.nih.gov/41241347/ |