Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine spp.
Fuente:
PubMed
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of natural products
2025
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266125110804480 |
|---|---|
| author | Xu, Quan Yan, Bing-Yuan Wang, Hui-Fang Wu, Qiong Li, Xu-Wen Zhang, Xiangyang |
| author_facet | Xu, Quan Yan, Bing-Yuan Wang, Hui-Fang Wu, Qiong Li, Xu-Wen Zhang, Xiangyang Xu, Quan Yan, Bing-Yuan Wang, Hui-Fang Wu, Qiong Li, Xu-Wen Zhang, Xiangyang |
| collection | PubMed - marine biology |
| contents | Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine spp. Xu, Quan Yan, Bing-Yuan Wang, Hui-Fang Wu, Qiong Li, Xu-Wen Zhang, Xiangyang Molecular Structure Humans Marine Biology Drug Screening Assays, Antitumor Structure-Activity Relationship HCT116 Cells Thiazoles Terphenyl Compounds Antineoplastic Agents Palladium We report the divergent total synthesis of marine natural products nocarterphenyl A (), 2-dehydroxymethylnocarterphenyl A (), and nocarterphenyl D (). The thiazole-fused -terphenyl core was synthesized via Suzuki-Miyaura coupling, and dibrominated precursor was obtained by dibromination of a multisubstituted benzothiazole using NBS/morpholine/HFIP. Nocarterphenyl D () was synthesized through palladium-catalyzed dehydrogenation cross-coupling. Biological evaluation revealed that nocarterphenyl A () inhibited HCT116 cell proliferation by 71% at 10 μM. Preliminary structure-activity relationships are discussed. |
| format | Artículo científico |
| id | pubmed_41247297 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of natural products |
| record_format | pubmed |
| spellingShingle | Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine spp. Xu, Quan Yan, Bing-Yuan Wang, Hui-Fang Wu, Qiong Li, Xu-Wen Zhang, Xiangyang Molecular Structure Humans Marine Biology Drug Screening Assays, Antitumor Structure-Activity Relationship HCT116 Cells Thiazoles Terphenyl Compounds Antineoplastic Agents Palladium Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine spp. Xu, Quan Yan, Bing-Yuan Wang, Hui-Fang Wu, Qiong Li, Xu-Wen Zhang, Xiangyang Molecular Structure Humans Marine Biology Drug Screening Assays, Antitumor Structure-Activity Relationship HCT116 Cells Thiazoles Terphenyl Compounds Antineoplastic Agents Palladium We report the divergent total synthesis of marine natural products nocarterphenyl A (), 2-dehydroxymethylnocarterphenyl A (), and nocarterphenyl D (). The thiazole-fused -terphenyl core was synthesized via Suzuki-Miyaura coupling, and dibrominated precursor was obtained by dibromination of a multisubstituted benzothiazole using NBS/morpholine/HFIP. Nocarterphenyl D () was synthesized through palladium-catalyzed dehydrogenation cross-coupling. Biological evaluation revealed that nocarterphenyl A () inhibited HCT116 cell proliferation by 71% at 10 μM. Preliminary structure-activity relationships are discussed. |
| title | Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine spp. |
| topic | Molecular Structure Humans Marine Biology Drug Screening Assays, Antitumor Structure-Activity Relationship HCT116 Cells Thiazoles Terphenyl Compounds Antineoplastic Agents Palladium |
| url | https://pubmed.ncbi.nlm.nih.gov/41247297/ |