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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of natural products
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41247297/ |
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Table of Contents:
- Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine spp. Xu, Quan Yan, Bing-Yuan Wang, Hui-Fang Wu, Qiong Li, Xu-Wen Zhang, Xiangyang Molecular Structure Humans Marine Biology Drug Screening Assays, Antitumor Structure-Activity Relationship HCT116 Cells Thiazoles Terphenyl Compounds Antineoplastic Agents Palladium We report the divergent total synthesis of marine natural products nocarterphenyl A (), 2-dehydroxymethylnocarterphenyl A (), and nocarterphenyl D (). The thiazole-fused -terphenyl core was synthesized via Suzuki-Miyaura coupling, and dibrominated precursor was obtained by dibromination of a multisubstituted benzothiazole using NBS/morpholine/HFIP. Nocarterphenyl D () was synthesized through palladium-catalyzed dehydrogenation cross-coupling. Biological evaluation revealed that nocarterphenyl A () inhibited HCT116 cell proliferation by 71% at 10 μM. Preliminary structure-activity relationships are discussed.