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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Fish & shellfish immunology
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41260279/ |
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| _version_ | 1868266125092978690 |
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| author | Zhang, Panpan Lin, Shuyi Xie, Zixin Chen, Guisen Cao, Zhenjie Zhang, Chen Ao, Jingqun Zhou, Yongcan Wu, Ying Sun, Yun |
| author_facet | Zhang, Panpan Lin, Shuyi Xie, Zixin Chen, Guisen Cao, Zhenjie Zhang, Chen Ao, Jingqun Zhou, Yongcan Wu, Ying Sun, Yun Zhang, Panpan Lin, Shuyi Xie, Zixin Chen, Guisen Cao, Zhenjie Zhang, Chen Ao, Jingqun Zhou, Yongcan Wu, Ying Sun, Yun |
| collection | PubMed - marine biology |
| contents | Pathogen-driven modulation of eight STATs in Cromileptes altivelis: Comparative analysis from homeostasis to immune activation. Zhang, Panpan Lin, Shuyi Xie, Zixin Chen, Guisen Cao, Zhenjie Zhang, Chen Ao, Jingqun Zhou, Yongcan Wu, Ying Sun, Yun Animals Fish Diseases Vibrio Phylogeny Fish Proteins Immunity, Innate Vibrio Infections Streptococcal Infections Homeostasis Streptococcus agalactiae Sequence Alignment Amino Acid Sequence Gene Expression Regulation Perciformes Gene Expression Profiling Signal transducer and activator of transcription (STAT) family members, which serve as transcription activators, play a central role in regulating inflammatory responses. While STATs have been well-characterized in mammals, systematic studies in fish remain scarce. In the present study, eight STATs in Cromileptes altivelis-CaSTAT1a, CaSTAT1b, CaSTAT2, CaSTAT3, CaSTAT4, CaSTAT5a, CaSTAT5b, and CaSTAT6-were characterized using PCR cloning and bioinformatics approaches. Phylogenetic analysis indicated that STATs have undergone significant evolutionary conservation throughout their lineage. Tissue expression patterns in healthy fish revealed that the eight CaSTATs displayed spatiotemporal specificity, with greater expression observed in gill, blood, and muscle. In response to bacterial (Vibrio harveyi, Streptococcus agalactiae) or viral (nervous necrosis virus, NNV) challenge, CaSTATs were robustly expressed and exhibited pathogen-, tissue-, and time-dependent expression divergence. In summary, our data highlight the indispensable roles of eight CaSTATs in modulating host immune responses. |
| format | Artículo científico |
| id | pubmed_41260279 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Fish & shellfish immunology |
| record_format | pubmed |
| spellingShingle | Pathogen-driven modulation of eight STATs in Cromileptes altivelis: Comparative analysis from homeostasis to immune activation. Zhang, Panpan Lin, Shuyi Xie, Zixin Chen, Guisen Cao, Zhenjie Zhang, Chen Ao, Jingqun Zhou, Yongcan Wu, Ying Sun, Yun Animals Fish Diseases Vibrio Phylogeny Fish Proteins Immunity, Innate Vibrio Infections Streptococcal Infections Homeostasis Streptococcus agalactiae Sequence Alignment Amino Acid Sequence Gene Expression Regulation Perciformes Gene Expression Profiling Pathogen-driven modulation of eight STATs in Cromileptes altivelis: Comparative analysis from homeostasis to immune activation. Zhang, Panpan Lin, Shuyi Xie, Zixin Chen, Guisen Cao, Zhenjie Zhang, Chen Ao, Jingqun Zhou, Yongcan Wu, Ying Sun, Yun Animals Fish Diseases Vibrio Phylogeny Fish Proteins Immunity, Innate Vibrio Infections Streptococcal Infections Homeostasis Streptococcus agalactiae Sequence Alignment Amino Acid Sequence Gene Expression Regulation Perciformes Gene Expression Profiling Signal transducer and activator of transcription (STAT) family members, which serve as transcription activators, play a central role in regulating inflammatory responses. While STATs have been well-characterized in mammals, systematic studies in fish remain scarce. In the present study, eight STATs in Cromileptes altivelis-CaSTAT1a, CaSTAT1b, CaSTAT2, CaSTAT3, CaSTAT4, CaSTAT5a, CaSTAT5b, and CaSTAT6-were characterized using PCR cloning and bioinformatics approaches. Phylogenetic analysis indicated that STATs have undergone significant evolutionary conservation throughout their lineage. Tissue expression patterns in healthy fish revealed that the eight CaSTATs displayed spatiotemporal specificity, with greater expression observed in gill, blood, and muscle. In response to bacterial (Vibrio harveyi, Streptococcus agalactiae) or viral (nervous necrosis virus, NNV) challenge, CaSTATs were robustly expressed and exhibited pathogen-, tissue-, and time-dependent expression divergence. In summary, our data highlight the indispensable roles of eight CaSTATs in modulating host immune responses. |
| title | Pathogen-driven modulation of eight STATs in Cromileptes altivelis: Comparative analysis from homeostasis to immune activation. |
| topic | Animals Fish Diseases Vibrio Phylogeny Fish Proteins Immunity, Innate Vibrio Infections Streptococcal Infections Homeostasis Streptococcus agalactiae Sequence Alignment Amino Acid Sequence Gene Expression Regulation Perciformes Gene Expression Profiling |
| url | https://pubmed.ncbi.nlm.nih.gov/41260279/ |