Mouse Brain Lymphatic Vessels.
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PubMed
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| Autores principales: | , , , , , , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
ACS chemical neuroscience
2025
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| _version_ | 1868266125089832960 |
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| author | Tamadon, Amin Afshar, Alireza Mussin, Nadiar M Zhilisbayeva, Kulyash R Kurmanalina, Madina A Baspakova, Akmaral Aringazina, Raisa A Mahdipour, Mahdi Tanideh, Nader Khoradmehr, Arezoo Najarasl, Mostafa Taheri, Payam |
| author_facet | Tamadon, Amin Afshar, Alireza Mussin, Nadiar M Zhilisbayeva, Kulyash R Kurmanalina, Madina A Baspakova, Akmaral Aringazina, Raisa A Mahdipour, Mahdi Tanideh, Nader Khoradmehr, Arezoo Najarasl, Mostafa Taheri, Payam Tamadon, Amin Afshar, Alireza Mussin, Nadiar M Zhilisbayeva, Kulyash R Kurmanalina, Madina A Baspakova, Akmaral Aringazina, Raisa A Mahdipour, Mahdi Tanideh, Nader Khoradmehr, Arezoo Najarasl, Mostafa Taheri, Payam |
| collection | PubMed - marine biology |
| contents | Mouse Brain Lymphatic Vessels. Tamadon, Amin Afshar, Alireza Mussin, Nadiar M Zhilisbayeva, Kulyash R Kurmanalina, Madina A Baspakova, Akmaral Aringazina, Raisa A Mahdipour, Mahdi Tanideh, Nader Khoradmehr, Arezoo Najarasl, Mostafa Taheri, Payam Animals Lymphatic Vessels Brain Mice, Inbred BALB C Mice Prospero-Related Homeobox 1 Protein Vascular Endothelial Growth Factor C Homeodomain Proteins Tumor Suppressor Proteins Platelet Endothelial Cell Adhesion Molecule-1 Male Membrane Transport Proteins This study provides evidence of lymphatic vessels in the mouse brain, specifically in the cortex, thalamus, and hippocampus. Using confocal microscopy, Western blotting, and real-time PCR, lymphatic vessels were identified by the expression of Lyve1, Prox1, and VEGFC, alongside endothelial markers CD31 and CD34. Paraffin-embedded brain slices from wild-type Balb/C mice were stained with antibodies against Lyve1, CD31, and CD34, revealing lymphatic vessels through 2D and 3D imaging. A coiled 3D structure of lymphatic vessels was observed in the hippocampus, indicating a complex drainage network. Western blot and real-time PCR analyses confirmed the presence of lymphatic and endothelial markers at the protein and mRNA levels. These findings demonstrate a lymphatic system extending from the meninges into deeper brain regions, offering insights into immune and waste clearance pathways in the central nervous system and potential therapeutic targets for neurological disorders. |
| format | Artículo científico |
| id | pubmed_41263424 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | ACS chemical neuroscience |
| record_format | pubmed |
| spellingShingle | Mouse Brain Lymphatic Vessels. Tamadon, Amin Afshar, Alireza Mussin, Nadiar M Zhilisbayeva, Kulyash R Kurmanalina, Madina A Baspakova, Akmaral Aringazina, Raisa A Mahdipour, Mahdi Tanideh, Nader Khoradmehr, Arezoo Najarasl, Mostafa Taheri, Payam Animals Lymphatic Vessels Brain Mice, Inbred BALB C Mice Prospero-Related Homeobox 1 Protein Vascular Endothelial Growth Factor C Homeodomain Proteins Tumor Suppressor Proteins Platelet Endothelial Cell Adhesion Molecule-1 Male Membrane Transport Proteins Mouse Brain Lymphatic Vessels. Tamadon, Amin Afshar, Alireza Mussin, Nadiar M Zhilisbayeva, Kulyash R Kurmanalina, Madina A Baspakova, Akmaral Aringazina, Raisa A Mahdipour, Mahdi Tanideh, Nader Khoradmehr, Arezoo Najarasl, Mostafa Taheri, Payam Animals Lymphatic Vessels Brain Mice, Inbred BALB C Mice Prospero-Related Homeobox 1 Protein Vascular Endothelial Growth Factor C Homeodomain Proteins Tumor Suppressor Proteins Platelet Endothelial Cell Adhesion Molecule-1 Male Membrane Transport Proteins This study provides evidence of lymphatic vessels in the mouse brain, specifically in the cortex, thalamus, and hippocampus. Using confocal microscopy, Western blotting, and real-time PCR, lymphatic vessels were identified by the expression of Lyve1, Prox1, and VEGFC, alongside endothelial markers CD31 and CD34. Paraffin-embedded brain slices from wild-type Balb/C mice were stained with antibodies against Lyve1, CD31, and CD34, revealing lymphatic vessels through 2D and 3D imaging. A coiled 3D structure of lymphatic vessels was observed in the hippocampus, indicating a complex drainage network. Western blot and real-time PCR analyses confirmed the presence of lymphatic and endothelial markers at the protein and mRNA levels. These findings demonstrate a lymphatic system extending from the meninges into deeper brain regions, offering insights into immune and waste clearance pathways in the central nervous system and potential therapeutic targets for neurological disorders. |
| title | Mouse Brain Lymphatic Vessels. |
| topic | Animals Lymphatic Vessels Brain Mice, Inbred BALB C Mice Prospero-Related Homeobox 1 Protein Vascular Endothelial Growth Factor C Homeodomain Proteins Tumor Suppressor Proteins Platelet Endothelial Cell Adhesion Molecule-1 Male Membrane Transport Proteins |
| url | https://pubmed.ncbi.nlm.nih.gov/41263424/ |