Genome-wide analysis unveils the differentiated "external" and "internal" lectin system in the tropical sea cucumber Holothuria leucospilota.
Fuente:
PubMed
Salvato in:
| Autori principali: | , , , , , , , , , , , , , |
|---|---|
| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Developmental and comparative immunology
2025
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1868266122562764801 |
|---|---|
| author | Ren, Xinyue Qin, Zhou Liu, Renhui Chen, Ting Lin, Tiehao Sun, Xinyu Huang, Jiasheng Pan, Wenjie Long, Caixia Ren, Chunhua Qin, Haipeng Zheng, Peiming Yan, Aifen Yuan, Lihong |
| author_facet | Ren, Xinyue Qin, Zhou Liu, Renhui Chen, Ting Lin, Tiehao Sun, Xinyu Huang, Jiasheng Pan, Wenjie Long, Caixia Ren, Chunhua Qin, Haipeng Zheng, Peiming Yan, Aifen Yuan, Lihong Ren, Xinyue Qin, Zhou Liu, Renhui Chen, Ting Lin, Tiehao Sun, Xinyu Huang, Jiasheng Pan, Wenjie Long, Caixia Ren, Chunhua Qin, Haipeng Zheng, Peiming Yan, Aifen Yuan, Lihong |
| collection | PubMed - marine biology |
| contents | Genome-wide analysis unveils the differentiated "external" and "internal" lectin system in the tropical sea cucumber Holothuria leucospilota. Ren, Xinyue Qin, Zhou Liu, Renhui Chen, Ting Lin, Tiehao Sun, Xinyu Huang, Jiasheng Pan, Wenjie Long, Caixia Ren, Chunhua Qin, Haipeng Zheng, Peiming Yan, Aifen Yuan, Lihong Animals Holothuria Immunity, Innate Lectins Vibrio Poly I-C Genome-Wide Association Study Lectins, C-Type Lipopolysaccharides Gene Expression Profiling Genome Transcriptome Phylogeny Sea Cucumbers To date, the understanding of lectin-related immunity in sea cucumbers remains limited. Through a comprehensive genome-wide analysis, 133 lectin genes were identified from Holothuria leucospilota, a sea cucumber species with high ecological and economic significance in the Pacific and Indian Oceans. These lectins were classified into five subtypes, with C-type lectin being the predominant form, and the presence of SUEL-like lectin and Malectin reported here for the first time in sea cucumbers. Transcriptomic analysis across twelve tissues and sixteen developmental stages revealed ubiquitous expression of H. leucospilota lectins. A key finding was the compartmentalization of lectin systems: SUEL-like lectins expressed in the body wall constitute an "external" defense system, while C-type lectins produced by coelomocytes form an "internal" immune system. This spatial and functional specialization reflects a sophisticated immune strategy in invertebrates, enabling targeted pathogen recognition at different bodily interfaces. Furthermore, distinct immune responses to Vibrio, LPS, and poly(I:C) were observed among different lectins. We also identified an ovary-specific C-type lectin, suggesting a potential role in early embryonic development. This study not only fills a knowledge gap regarding lectin genes in sea cucumbers but also establishes a broader framework for understanding complex immune mechanisms in echinoderms. |
| format | Artículo científico |
| id | pubmed_41274536 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Developmental and comparative immunology |
| record_format | pubmed |
| spellingShingle | Genome-wide analysis unveils the differentiated "external" and "internal" lectin system in the tropical sea cucumber Holothuria leucospilota. Ren, Xinyue Qin, Zhou Liu, Renhui Chen, Ting Lin, Tiehao Sun, Xinyu Huang, Jiasheng Pan, Wenjie Long, Caixia Ren, Chunhua Qin, Haipeng Zheng, Peiming Yan, Aifen Yuan, Lihong Animals Holothuria Immunity, Innate Lectins Vibrio Poly I-C Genome-Wide Association Study Lectins, C-Type Lipopolysaccharides Gene Expression Profiling Genome Transcriptome Phylogeny Sea Cucumbers Genome-wide analysis unveils the differentiated "external" and "internal" lectin system in the tropical sea cucumber Holothuria leucospilota. Ren, Xinyue Qin, Zhou Liu, Renhui Chen, Ting Lin, Tiehao Sun, Xinyu Huang, Jiasheng Pan, Wenjie Long, Caixia Ren, Chunhua Qin, Haipeng Zheng, Peiming Yan, Aifen Yuan, Lihong Animals Holothuria Immunity, Innate Lectins Vibrio Poly I-C Genome-Wide Association Study Lectins, C-Type Lipopolysaccharides Gene Expression Profiling Genome Transcriptome Phylogeny Sea Cucumbers To date, the understanding of lectin-related immunity in sea cucumbers remains limited. Through a comprehensive genome-wide analysis, 133 lectin genes were identified from Holothuria leucospilota, a sea cucumber species with high ecological and economic significance in the Pacific and Indian Oceans. These lectins were classified into five subtypes, with C-type lectin being the predominant form, and the presence of SUEL-like lectin and Malectin reported here for the first time in sea cucumbers. Transcriptomic analysis across twelve tissues and sixteen developmental stages revealed ubiquitous expression of H. leucospilota lectins. A key finding was the compartmentalization of lectin systems: SUEL-like lectins expressed in the body wall constitute an "external" defense system, while C-type lectins produced by coelomocytes form an "internal" immune system. This spatial and functional specialization reflects a sophisticated immune strategy in invertebrates, enabling targeted pathogen recognition at different bodily interfaces. Furthermore, distinct immune responses to Vibrio, LPS, and poly(I:C) were observed among different lectins. We also identified an ovary-specific C-type lectin, suggesting a potential role in early embryonic development. This study not only fills a knowledge gap regarding lectin genes in sea cucumbers but also establishes a broader framework for understanding complex immune mechanisms in echinoderms. |
| title | Genome-wide analysis unveils the differentiated "external" and "internal" lectin system in the tropical sea cucumber Holothuria leucospilota. |
| topic | Animals Holothuria Immunity, Innate Lectins Vibrio Poly I-C Genome-Wide Association Study Lectins, C-Type Lipopolysaccharides Gene Expression Profiling Genome Transcriptome Phylogeny Sea Cucumbers |
| url | https://pubmed.ncbi.nlm.nih.gov/41274536/ |