High hydrostatic pressure modulates copper and cadmium accumulation and biomarker responses in Modiolus kurilensis: Implications for deep-sea mining risk assessment.
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
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Ecotoxicology and environmental safety
2025
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| _version_ | 1868266122560667649 |
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| author | Zhou, Li Zhong, Zhaoshan Lian, Chao He, Yameng Wang, Minxiao Chen, Hao Fu, Lulu Ma, Manman Sun, Yan Li, Chaolun |
| author_facet | Zhou, Li Zhong, Zhaoshan Lian, Chao He, Yameng Wang, Minxiao Chen, Hao Fu, Lulu Ma, Manman Sun, Yan Li, Chaolun Zhou, Li Zhong, Zhaoshan Lian, Chao He, Yameng Wang, Minxiao Chen, Hao Fu, Lulu Ma, Manman Sun, Yan Li, Chaolun |
| collection | PubMed - marine biology |
| contents | High hydrostatic pressure modulates copper and cadmium accumulation and biomarker responses in Modiolus kurilensis: Implications for deep-sea mining risk assessment. Zhou, Li Zhong, Zhaoshan Lian, Chao He, Yameng Wang, Minxiao Chen, Hao Fu, Lulu Ma, Manman Sun, Yan Li, Chaolun Animals Cadmium Water Pollutants, Chemical Mining Copper Biomarkers Hydrostatic Pressure Risk Assessment Environmental Monitoring Gills Bivalvia As deep-sea mining approaches commercial implementation, evaluating contaminant risks under realistic environmental conditions-particularly high hydrostatic pressure (HP)-has become increasingly critical. Yet, most existing toxicological studies are conducted under atmospheric pressure, potentially overlooking pressure-induced modifications in metal behavior and biological response. In this 48-hour exposure study, we used the coastal mussel Modiolus kurilensis, a close relative of deep-sea Bathymodiolins, to investigate its biological responses to copper (Cu) and cadmium (Cd) exposure (100 μg/L) under both atmospheric and simulated deep-sea pressure. We assessed metal accumulation and 13 traditional metal-related biochemical biomarkers across gill, mantle, and visceral mass. Results showed that HP significantly reshaped metal accumulation in a tissue- and metal-specific manner, enhancing Cu and Cd uptake in gill and mantle, and selectively promoting Cd retention in visceral mass. Correspondingly, HP reprogrammed biochemical responses: mantle reactivity was suppressed, gill detoxification intensified, and visceral mass shifted toward lipid oxidative damage and metabolic disruption. Critically, by comparing responses across both pressure conditions, we identified two pressure-insensitive biomarkers-acid phosphatase and hexokinase in the mantle-that consistently responded to metal exposure regardless of pressure. These biomarkers hold strong potential for pressure-independent biomonitoring. In contrast, many conventional biomarkers showed divergent responses under HP, highlighting the risk of misinterpretation if pressure effects are ignored. Our study offers a pressure-aware framework for deep-sea ecotoxicology using coastal proxies and provides essential guidance for selecting reliable biomarkers for future environmental risk assessments of deep-sea mining. |
| format | Artículo científico |
| id | pubmed_41275635 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Ecotoxicology and environmental safety |
| record_format | pubmed |
| spellingShingle | High hydrostatic pressure modulates copper and cadmium accumulation and biomarker responses in Modiolus kurilensis: Implications for deep-sea mining risk assessment. Zhou, Li Zhong, Zhaoshan Lian, Chao He, Yameng Wang, Minxiao Chen, Hao Fu, Lulu Ma, Manman Sun, Yan Li, Chaolun Animals Cadmium Water Pollutants, Chemical Mining Copper Biomarkers Hydrostatic Pressure Risk Assessment Environmental Monitoring Gills Bivalvia High hydrostatic pressure modulates copper and cadmium accumulation and biomarker responses in Modiolus kurilensis: Implications for deep-sea mining risk assessment. Zhou, Li Zhong, Zhaoshan Lian, Chao He, Yameng Wang, Minxiao Chen, Hao Fu, Lulu Ma, Manman Sun, Yan Li, Chaolun Animals Cadmium Water Pollutants, Chemical Mining Copper Biomarkers Hydrostatic Pressure Risk Assessment Environmental Monitoring Gills Bivalvia As deep-sea mining approaches commercial implementation, evaluating contaminant risks under realistic environmental conditions-particularly high hydrostatic pressure (HP)-has become increasingly critical. Yet, most existing toxicological studies are conducted under atmospheric pressure, potentially overlooking pressure-induced modifications in metal behavior and biological response. In this 48-hour exposure study, we used the coastal mussel Modiolus kurilensis, a close relative of deep-sea Bathymodiolins, to investigate its biological responses to copper (Cu) and cadmium (Cd) exposure (100 μg/L) under both atmospheric and simulated deep-sea pressure. We assessed metal accumulation and 13 traditional metal-related biochemical biomarkers across gill, mantle, and visceral mass. Results showed that HP significantly reshaped metal accumulation in a tissue- and metal-specific manner, enhancing Cu and Cd uptake in gill and mantle, and selectively promoting Cd retention in visceral mass. Correspondingly, HP reprogrammed biochemical responses: mantle reactivity was suppressed, gill detoxification intensified, and visceral mass shifted toward lipid oxidative damage and metabolic disruption. Critically, by comparing responses across both pressure conditions, we identified two pressure-insensitive biomarkers-acid phosphatase and hexokinase in the mantle-that consistently responded to metal exposure regardless of pressure. These biomarkers hold strong potential for pressure-independent biomonitoring. In contrast, many conventional biomarkers showed divergent responses under HP, highlighting the risk of misinterpretation if pressure effects are ignored. Our study offers a pressure-aware framework for deep-sea ecotoxicology using coastal proxies and provides essential guidance for selecting reliable biomarkers for future environmental risk assessments of deep-sea mining. |
| title | High hydrostatic pressure modulates copper and cadmium accumulation and biomarker responses in Modiolus kurilensis: Implications for deep-sea mining risk assessment. |
| topic | Animals Cadmium Water Pollutants, Chemical Mining Copper Biomarkers Hydrostatic Pressure Risk Assessment Environmental Monitoring Gills Bivalvia |
| url | https://pubmed.ncbi.nlm.nih.gov/41275635/ |