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Main Authors:	Chen, Kuang-Wen, Huang, Chien-Fu, Wu, Jen-Leih, Hong, Jiann-Ruey
Format:	Artículo científico
Language:	en
Published:	Fish & shellfish immunology 2026
Subjects:	Animals Autophagy Docosahexaenoic Acids Virus Replication Fish Diseases Cell Line Beclin-1 TOR Serine-Threonine Kinases Autophagy-Related Protein-1 Homolog Signal Transduction Fish Proteins
Online Access:	https://pubmed.ncbi.nlm.nih.gov/41275980/
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Computational Analysis of Azole Derivatives Targeting the PI3K/AKT/mTOR Pathway With In Vitro Cytotoxicity and Autophagy Evaluation.
by: Regurajan, Rathika, et al.
Published: (2026)

Fish TOLLIP manipulates ATG5 for autophagic degradation of STING to attenuate antiviral interferon responses.
by: Tian, Meng-Ze, et al.
Published: (2025)

Hijacking of host Src-PI3K-Akt signaling by WSSV IE1 protein suppresses apoptotic and autophagic defenses to facilitate viral proliferation.
by: Lu, Kaiyu, et al.
Published: (2026)

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response.
by: Lu, Long-Feng, et al.
Published: (2026)

BIK1 and ATL31/6 are essential for fucoidan hydrolysate-triggered stomatal closure in Arabidopsis.
by: Chen, Kexin, et al.
Published: (2025)

Primary Cilia-Mediated Hedgehog Signaling Regulates Cell Fate During ER Stress-Induced Life or Death Decisions.
by: Xu, Jia, et al.
Published: (2025)

Diphenyl Disulfide Exerts Dual Cytotoxic Effects by Inducing Ferroptosis and Apoptosis in Melanoma Cells.
by: Chen, Sheng-Yuan, et al.
Published: (2026)

Evolutionary analysis and immune-induced expression and mA modification of RIPK1 and RIPK2 in the miiuy croaker.
by: Xing, Qianru, et al.
Published: (2025)

SVCV phosphoprotein hijacks phase separation to immobilize the IRF3-TBK1 signaling axis and suppress interferon antiviral immunity.
by: Wang, Yueyi, et al.
Published: (2026)

pacsin1 inhibits antiviral immunity by promoting MITA degradation through autophagy in miiuy croaker, Miichthysmiiuy.
by: Li, Wenxin, et al.
Published: (2025)

Hippo-YAP pathway regulates antimicrobial immune response in obscure puffer Takifugu obscurus.
by: Wang, Ruixia, et al.
Published: (2025)

RAPTOR-mediated autophagy promotes the accumulation of lipid and terpenoids in Schizochytrium sp. HX-308.
by: Yan, Chunxiao, et al.
Published: (2026)

Grass carp reovirus VP4 manipulates TOLLIP to degrade STING for inhibition of IFN production.
by: Wang, Yang-Yang, et al.
Published: (2025)

Rewiring mTOR signaling in Alzheimer's disease: emerging mTOR modulators beyond oncology.
by: Lohnes, Benedikt Jakob, et al.
Published: (2026)

Autophagic degradation of MAVS-B by Carassius auratus herpesvirus (CaHV) ORF56 suppresses interferon response in polyploid gibel carp.
by: Zhou, Chu-Jing, et al.
Published: (2026)

A nutrient-responsive AMPK/TBK1 circuit restricts adipocyte catabolism.
by: Wisessaowapak, Churaibhon, et al.
Published: (2026)

Phosphoethanolamine cytidylyltransferase 2 integrates DAG metabolism and TBK1 activation to regulate antiviral innate immunity.
by: Lai, Wencong, et al.
Published: (2026)

Grouper deubiquitinating enzyme ovarian tumor domain-containing protein 5 (OTUD5) stabilizes stimulator of interferon genes (STING) via the autophagy-lysosomal pathway to modulate antiviral innate immunity in fish.
by: Wu, Siting, et al.
Published: (2026)

Lipid Droplet Degradation Through Lipophagy in Aurantiochytrium limacinum mh0186.
by: Wu, Sheng, et al.
Published: (2025)

Activation of prep expression by Tet2 promotes the proliferation of bipotential progenitor cells during liver regeneration.
by: Jia, Kun, et al.
Published: (2025)

Elucidation of anti-human melanoma and anti-aging mechanisms of compounds from green seaweed Caulerpa racemosa.
by: Wicaksono, Danar, et al.
Published: (2024)

Sex-Specific Lifespan Extension and Anti-Obesogenic Effects of Extract Through Tor Signaling Modulation in .
by: Tahan Zadeh, Navid, et al.
Published: (2025)

Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications for Human Aging and Longevity.
by: Jalouli, Maroua, et al.
Published: (2026)

Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships.
by: Bourg, Stéphane, et al.
Published: (2026)

Zebrafish TRIM2a promotes virus replication via ubiquitination of IRF3 and autophagic cargo receptor p62.
by: Huang, Wenji, et al.
Published: (2025)

In vitro cytotoxic and pro-apoptotic effects of Chaetoceros socialis ethanolic extract on prostate (LNCap) and glioblastoma (U-87 MG) cells via modulation of AKT/PTEN, mTOR, BAX/BCL2, and Caspase pathways.
by: Asoudeh-Fard, Abbas, et al.
Published: (2025)

Zebrafish fkbp5 attenuates antiviral innate immunity by autophagic degradation of transcription factor irf7.
by: Wang, Yanyi, et al.
Published: (2025)

Aglaia elliptifolia Leaf Extract Inhibits Autophagy-Related 4B Protease and Suppresses Malignancies of Colorectal Cancer Cells.
by: Weng, Jing-Ru, et al.
Published: (2025)

β-defensin 2 enhances antiviral immunity via autophagy regulation during Micropterus salmoides rhabdovirus (MSRV) infection and promotes survival in largemouth bass.
by: Zhu, Yong-Fei, et al.
Published: (2026)

Identification of Marine Compounds Inhibiting NF-κBInducing Kinase Through Molecular Docking and Molecular Dynamics Simulations.
by: Yasir, Muhammad, et al.
Published: (2024)

Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress.
by: Ye, Haicheng, et al.
Published: (2025)

Synthesis and biological activity of 1H-pyrrolo[3,2-g]isoquinolines as Haspin kinase inhibitors.
by: Malosse, Killian, et al.
Published: (2025)

plecoglossicida infection induces neutrophil autophagy-driven NETosis in large yellow croaker .
by: Cao, Jia-Feng, et al.
Published: (2024)

Data-Independent Acquisition-Based Quantitative Proteomics, Nontargeted Metabolomics, and Protein-Ligand Interaction Reveal the Mechanism of Baicalin Inhibiting βhemolytic/cytolytic Activities of .
by: Li, Guihua, et al.
Published: (2026)

Chryxanthone A, an extracted substance from endophytic fungal Aspergillus versicolor, produces anti-oxidant neuroprotection possibly via the action on mTOR/CREB axis.
by: Zhang, Xinyu, et al.
Published: (2025)

RNF34 negatively regulates innate immunity via ubiquitin-mediated TAK1 degradation in miiuy croaker (Miichthysmiiuy).
by: Dong, Wenjing, et al.
Published: (2025)

Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors.
by: Du, Lin, et al.
Published: (2025)

The novel marine factor 3,5-dihydroxy-4-methoxybenzyl alcohol exhibits anticancer activity by regulating multiple signaling pathways in human glioblastoma cells: Blocking EGF signaling.
by: Yamaguchi, Masayoshi, et al.
Published: (2025)

if (filemtime($filename) + $maxlifetime < time()) { unlink($filename); $count++; } } return $count; } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ protected function saveSession($sessId, $data): bool { $sessFile = $this->path . '/sess_' . $sessId; if ($handle = fopen($sessFile, 'w')) { $return = false; // Lock the file for exclusive access to avoid issues with multiple // processes writing session simultaneously: if (flock($handle, LOCK_EX)) { $return = fwrite($handle, $data); // Make sure that there's no trailing data by truncating the file to // the correct length: ftruncate($handle, strlen($data)); fflush($handle); flock($handle, LOCK_UN); } fclose($handle); if ($return !== false) { return true; } } // If we got this far, something went wrong with the file output... // It is tempting to throw an exception here, but this code is called // outside of the context of exception handling, so all we can do is // echo a message.

// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

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