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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
bioRxiv : the preprint server for biology
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41279319/ |
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Table of Contents:
- Genomic and genetic insights into speciation and pigment pattern diversification in fishes. Lu, Jianguo Podobnik, Marco Huang, Junrou McCluskey, Braedan M McCarthy, Shane A Wood, Jonathan Collins, Joanna Torrance, James Sims, Ying Gao, Dong Huang, Jing Liu, Jia Fang, Wenyu Huang, Peilin Ma, Chunlei Parichy, David Irion, Uwe Liu, Jian Howe, Kerstin Postlethwait, John H The Danioninae subfamily of teleost fishes boasts up to four hundred distinct species that have evolved to display a stunning diversity of morphological forms. Here we use newly assembled genome sequences of four laboratory and wild zebrafish strains as well as eleven species of the and genera to explore their phylogenetic history and the genetic basis of pigment pattern diversification. Phylogenomic analyses uncover extensive introgression and incomplete lineage sorting that have obscured phylogenetic relationships within and corroborate an ancient hybrid origin of zebrafish. Whereas inherited ancestral horizontal stripes, relatives repeatedly evolved spots and vertical bars. Interspecific complementation tests reveal functional divergence of the adhesion molecule gene and the gap junction gene between the striped zebrafish and species with divergent patterns. Comparative genomic and transcriptomic analyses suggest that protein and regulatory evolution have accompanied pigment pattern diversification. Our analyses elucidate complex genetic changes underlying the phylogenetic history and morphological diversification in the genus. Resolved phylogenetic relationships, available genome assemblies, transcriptomes, and genetic tractability establish fish species as excellent models for biomedical research in vertebrates.