Evaluation of genes and molecular pathways involved in ferroptosis in breast cancer: A systems biology and bioinformatics approach.
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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Biochemistry and biophysics reports
2025
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| author | Heydari, Arezu Yaghmoorian Khojini, Javad Hayati, Mohammad Javad Khara, Fatemeh Abootorabi, Seyed Mohammad Sadra Manoochehri, Hamed Mousavi, Mohammad Javad |
| author_facet | Heydari, Arezu Yaghmoorian Khojini, Javad Hayati, Mohammad Javad Khara, Fatemeh Abootorabi, Seyed Mohammad Sadra Manoochehri, Hamed Mousavi, Mohammad Javad Heydari, Arezu Yaghmoorian Khojini, Javad Hayati, Mohammad Javad Khara, Fatemeh Abootorabi, Seyed Mohammad Sadra Manoochehri, Hamed Mousavi, Mohammad Javad |
| collection | PubMed - marine biology |
| contents | Evaluation of genes and molecular pathways involved in ferroptosis in breast cancer: A systems biology and bioinformatics approach. Heydari, Arezu Yaghmoorian Khojini, Javad Hayati, Mohammad Javad Khara, Fatemeh Abootorabi, Seyed Mohammad Sadra Manoochehri, Hamed Mousavi, Mohammad Javad Breast cancer (BC) is a leading cause of cancer mortality worldwide. Ferroptosis, an unique form of iron-dependent cell death, has emerged as a promising therapeutic target to overcome drug resistance. This study aimed to identify key ferroptosis-related genes and their regulatory pathways that are dysregulated in BC. Through a systems biology approach, we analyzed gene expression data from two independent GEO datasets. We identified differentially expressed genes (DEGs) in tumor versus normal tissues and intersected them with a curated database of ferroptosis regulators to define a high-confidence list of Ferroptosis-related DEGs (FeffDEGs). Subsequently, we performed functional enrichment, protein-protein interaction (PPI) network analysis to identify hub genes, and explored their potential regulatory miRNAs and transcription factors (TFs). We identified 73 FeffDEGs significantly enriched in pathways related to oxidative stress and lipid metabolism. Seven hub genes were pinpointed, including the upregulated oncogene and the downregulated tumor suppressor . Further analysis revealed that these hub genes are potentially regulated by key molecules such as and the transcription factor AR. Our findings highlight that hub genes like and are potential biomarkers and therapeutic targets for modulating ferroptosis in breast cancer. These results provide a strong foundation for future experimental validation to translate computational insights into clinical applications. |
| format | Artículo científico |
| id | pubmed_41282538 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Biochemistry and biophysics reports |
| record_format | pubmed |
| spellingShingle | Evaluation of genes and molecular pathways involved in ferroptosis in breast cancer: A systems biology and bioinformatics approach. Heydari, Arezu Yaghmoorian Khojini, Javad Hayati, Mohammad Javad Khara, Fatemeh Abootorabi, Seyed Mohammad Sadra Manoochehri, Hamed Mousavi, Mohammad Javad Evaluation of genes and molecular pathways involved in ferroptosis in breast cancer: A systems biology and bioinformatics approach. Heydari, Arezu Yaghmoorian Khojini, Javad Hayati, Mohammad Javad Khara, Fatemeh Abootorabi, Seyed Mohammad Sadra Manoochehri, Hamed Mousavi, Mohammad Javad Breast cancer (BC) is a leading cause of cancer mortality worldwide. Ferroptosis, an unique form of iron-dependent cell death, has emerged as a promising therapeutic target to overcome drug resistance. This study aimed to identify key ferroptosis-related genes and their regulatory pathways that are dysregulated in BC. Through a systems biology approach, we analyzed gene expression data from two independent GEO datasets. We identified differentially expressed genes (DEGs) in tumor versus normal tissues and intersected them with a curated database of ferroptosis regulators to define a high-confidence list of Ferroptosis-related DEGs (FeffDEGs). Subsequently, we performed functional enrichment, protein-protein interaction (PPI) network analysis to identify hub genes, and explored their potential regulatory miRNAs and transcription factors (TFs). We identified 73 FeffDEGs significantly enriched in pathways related to oxidative stress and lipid metabolism. Seven hub genes were pinpointed, including the upregulated oncogene and the downregulated tumor suppressor . Further analysis revealed that these hub genes are potentially regulated by key molecules such as and the transcription factor AR. Our findings highlight that hub genes like and are potential biomarkers and therapeutic targets for modulating ferroptosis in breast cancer. These results provide a strong foundation for future experimental validation to translate computational insights into clinical applications. |
| title | Evaluation of genes and molecular pathways involved in ferroptosis in breast cancer: A systems biology and bioinformatics approach. |
| url | https://pubmed.ncbi.nlm.nih.gov/41282538/ |