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| Format: | Artículo científico |
| Language: | en |
| Published: |
Science (New York, N.Y.)
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41296989/ |
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| author | Ostridge, Harrison J Fontsere, Claudia Lizano, Esther Soto, Daniela C Schmidt, Joshua M Saxena, Vrishti Alvarez-Estape, Marina Barratt, Christopher D Gratton, Paolo Bocksberger, Gaëlle Lester, Jack D Dieguez, Paula Agbor, Anthony Angedakin, Samuel Assumang, Alfred Kwabena Bailey, Emma Barubiyo, Donatienne Bessone, Mattia Brazzola, Gregory Chancellor, Rebecca Cohen, Heather Coupland, Charlotte Danquah, Emmanuel Deschner, Tobias Dotras, Laia Dupain, Jef Egbe, Villard Ebot Granjon, Anne-Céline Head, Josephine Hedwig, Daniela Hermans, Veerle Hernandez-Aguilar, R Adriana Jeffery, Kathryn J Jones, Sorrel Junker, Jessica Kadam, Parag Kaiser, Michael Kalan, Ammie K Kambere, Mbangi Kienast, Ivonne Kujirakwinja, Deo Langergraber, Kevin E Lapuente, Juan Larson, Bradley Laudisoit, Anne Lee, Kevin C Llana, Manuel Maretti, Giovanna Martín, Rumen Meier, Amelia C Morgan, David Neil, Emily Nicholl, Sonia Nixon, Stuart Normand, Emmanuelle Orbell, Christopher Ormsby, Lucy Jayne Orume, Robinson Pacheco, Liliana Preece, Jodie Regnaut, Sebastien Robbins, Martha M Rundus, Aaron Sanz, Crickette Sciaky, Lilah Sommer, Volker Stewart, Fiona A Tagg, Nikki Tédonzong, Luc Roscelin van Schijndel, Joost Vendras, Elleni Wessling, Erin G Willie, Jacob Wittig, Roman M Yuh, Yisa Ginath Yurkiw, Kyle Vigilant, Linda Piel, Alex K Boesch, Christophe Kühl, Hjalmar S Dennis, Megan Y Marques-Bonet, Tomas Arandjelovic, Mimi Andrés, Aida M |
| author_facet | Ostridge, Harrison J Fontsere, Claudia Lizano, Esther Soto, Daniela C Schmidt, Joshua M Saxena, Vrishti Alvarez-Estape, Marina Barratt, Christopher D Gratton, Paolo Bocksberger, Gaëlle Lester, Jack D Dieguez, Paula Agbor, Anthony Angedakin, Samuel Assumang, Alfred Kwabena Bailey, Emma Barubiyo, Donatienne Bessone, Mattia Brazzola, Gregory Chancellor, Rebecca Cohen, Heather Coupland, Charlotte Danquah, Emmanuel Deschner, Tobias Dotras, Laia Dupain, Jef Egbe, Villard Ebot Granjon, Anne-Céline Head, Josephine Hedwig, Daniela Hermans, Veerle Hernandez-Aguilar, R Adriana Jeffery, Kathryn J Jones, Sorrel Junker, Jessica Kadam, Parag Kaiser, Michael Kalan, Ammie K Kambere, Mbangi Kienast, Ivonne Kujirakwinja, Deo Langergraber, Kevin E Lapuente, Juan Larson, Bradley Laudisoit, Anne Lee, Kevin C Llana, Manuel Maretti, Giovanna Martín, Rumen Meier, Amelia C Morgan, David Neil, Emily Nicholl, Sonia Nixon, Stuart Normand, Emmanuelle Orbell, Christopher Ormsby, Lucy Jayne Orume, Robinson Pacheco, Liliana Preece, Jodie Regnaut, Sebastien Robbins, Martha M Rundus, Aaron Sanz, Crickette Sciaky, Lilah Sommer, Volker Stewart, Fiona A Tagg, Nikki Tédonzong, Luc Roscelin van Schijndel, Joost Vendras, Elleni Wessling, Erin G Willie, Jacob Wittig, Roman M Yuh, Yisa Ginath Yurkiw, Kyle Vigilant, Linda Piel, Alex K Boesch, Christophe Kühl, Hjalmar S Dennis, Megan Y Marques-Bonet, Tomas Arandjelovic, Mimi Andrés, Aida M Ostridge, Harrison J Fontsere, Claudia Lizano, Esther Soto, Daniela C Schmidt, Joshua M Saxena, Vrishti Alvarez-Estape, Marina Barratt, Christopher D Gratton, Paolo Bocksberger, Gaëlle Lester, Jack D Dieguez, Paula Agbor, Anthony Angedakin, Samuel Assumang, Alfred Kwabena Bailey, Emma Barubiyo, Donatienne Bessone, Mattia Brazzola, Gregory Chancellor, Rebecca Cohen, Heather Coupland, Charlotte Danquah, Emmanuel Deschner, Tobias Dotras, Laia Dupain, Jef Egbe, Villard Ebot Granjon, Anne-Céline Head, Josephine Hedwig, Daniela Hermans, Veerle Hernandez-Aguilar, R Adriana Jeffery, Kathryn J Jones, Sorrel Junker, Jessica Kadam, Parag Kaiser, Michael Kalan, Ammie K Kambere, Mbangi Kienast, Ivonne Kujirakwinja, Deo Langergraber, Kevin E Lapuente, Juan Larson, Bradley Laudisoit, Anne Lee, Kevin C Llana, Manuel Maretti, Giovanna Martín, Rumen Meier, Amelia C Morgan, David Neil, Emily Nicholl, Sonia Nixon, Stuart Normand, Emmanuelle Orbell, Christopher Ormsby, Lucy Jayne Orume, Robinson Pacheco, Liliana Preece, Jodie Regnaut, Sebastien Robbins, Martha M Rundus, Aaron Sanz, Crickette Sciaky, Lilah Sommer, Volker Stewart, Fiona A Tagg, Nikki Tédonzong, Luc Roscelin van Schijndel, Joost Vendras, Elleni Wessling, Erin G Willie, Jacob Wittig, Roman M Yuh, Yisa Ginath Yurkiw, Kyle Vigilant, Linda Piel, Alex K Boesch, Christophe Kühl, Hjalmar S Dennis, Megan Y Marques-Bonet, Tomas Arandjelovic, Mimi Andrés, Aida M |
| collection | PubMed - marine biology |
| contents | Local genetic adaptation to habitat in wild chimpanzees. Ostridge, Harrison J Fontsere, Claudia Lizano, Esther Soto, Daniela C Schmidt, Joshua M Saxena, Vrishti Alvarez-Estape, Marina Barratt, Christopher D Gratton, Paolo Bocksberger, Gaëlle Lester, Jack D Dieguez, Paula Agbor, Anthony Angedakin, Samuel Assumang, Alfred Kwabena Bailey, Emma Barubiyo, Donatienne Bessone, Mattia Brazzola, Gregory Chancellor, Rebecca Cohen, Heather Coupland, Charlotte Danquah, Emmanuel Deschner, Tobias Dotras, Laia Dupain, Jef Egbe, Villard Ebot Granjon, Anne-Céline Head, Josephine Hedwig, Daniela Hermans, Veerle Hernandez-Aguilar, R Adriana Jeffery, Kathryn J Jones, Sorrel Junker, Jessica Kadam, Parag Kaiser, Michael Kalan, Ammie K Kambere, Mbangi Kienast, Ivonne Kujirakwinja, Deo Langergraber, Kevin E Lapuente, Juan Larson, Bradley Laudisoit, Anne Lee, Kevin C Llana, Manuel Maretti, Giovanna Martín, Rumen Meier, Amelia C Morgan, David Neil, Emily Nicholl, Sonia Nixon, Stuart Normand, Emmanuelle Orbell, Christopher Ormsby, Lucy Jayne Orume, Robinson Pacheco, Liliana Preece, Jodie Regnaut, Sebastien Robbins, Martha M Rundus, Aaron Sanz, Crickette Sciaky, Lilah Sommer, Volker Stewart, Fiona A Tagg, Nikki Tédonzong, Luc Roscelin van Schijndel, Joost Vendras, Elleni Wessling, Erin G Willie, Jacob Wittig, Roman M Yuh, Yisa Ginath Yurkiw, Kyle Vigilant, Linda Piel, Alex K Boesch, Christophe Kühl, Hjalmar S Dennis, Megan Y Marques-Bonet, Tomas Arandjelovic, Mimi Andrés, Aida M Animals Adaptation, Physiological Ecosystem Endangered Species Genetic Variation Malaria Pan troglodytes Selection, Genetic Population Genomics How populations adapt to their environment is a fundamental question in biology. Yet, we know surprisingly little about this process, especially for endangered species, such as nonhuman great apes. Chimpanzees, our closest living relatives, are particularly notable because they inhabit diverse habitats, from rainforest to woodland-savannah. Whether genetic adaptation facilitates such habitat diversity remains unknown, despite it having wide implications for evolutionary biology and conservation. By using newly sequenced exomes from 828 wild chimpanzees (388 postfiltering), we found evidence of fine-scale genetic adaptation to habitat, with signatures of positive selection in forest chimpanzees in the same genes underlying adaptation to malaria in humans. This work demonstrates the power of noninvasive samples to reveal genetic adaptations in endangered populations and highlights the importance of adaptive genetic diversity for chimpanzees. |
| format | Artículo científico |
| id | pubmed_41296989 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Science (New York, N.Y.) |
| record_format | pubmed |
| spellingShingle | Local genetic adaptation to habitat in wild chimpanzees. Ostridge, Harrison J Fontsere, Claudia Lizano, Esther Soto, Daniela C Schmidt, Joshua M Saxena, Vrishti Alvarez-Estape, Marina Barratt, Christopher D Gratton, Paolo Bocksberger, Gaëlle Lester, Jack D Dieguez, Paula Agbor, Anthony Angedakin, Samuel Assumang, Alfred Kwabena Bailey, Emma Barubiyo, Donatienne Bessone, Mattia Brazzola, Gregory Chancellor, Rebecca Cohen, Heather Coupland, Charlotte Danquah, Emmanuel Deschner, Tobias Dotras, Laia Dupain, Jef Egbe, Villard Ebot Granjon, Anne-Céline Head, Josephine Hedwig, Daniela Hermans, Veerle Hernandez-Aguilar, R Adriana Jeffery, Kathryn J Jones, Sorrel Junker, Jessica Kadam, Parag Kaiser, Michael Kalan, Ammie K Kambere, Mbangi Kienast, Ivonne Kujirakwinja, Deo Langergraber, Kevin E Lapuente, Juan Larson, Bradley Laudisoit, Anne Lee, Kevin C Llana, Manuel Maretti, Giovanna Martín, Rumen Meier, Amelia C Morgan, David Neil, Emily Nicholl, Sonia Nixon, Stuart Normand, Emmanuelle Orbell, Christopher Ormsby, Lucy Jayne Orume, Robinson Pacheco, Liliana Preece, Jodie Regnaut, Sebastien Robbins, Martha M Rundus, Aaron Sanz, Crickette Sciaky, Lilah Sommer, Volker Stewart, Fiona A Tagg, Nikki Tédonzong, Luc Roscelin van Schijndel, Joost Vendras, Elleni Wessling, Erin G Willie, Jacob Wittig, Roman M Yuh, Yisa Ginath Yurkiw, Kyle Vigilant, Linda Piel, Alex K Boesch, Christophe Kühl, Hjalmar S Dennis, Megan Y Marques-Bonet, Tomas Arandjelovic, Mimi Andrés, Aida M Animals Adaptation, Physiological Ecosystem Endangered Species Genetic Variation Malaria Pan troglodytes Selection, Genetic Population Genomics Local genetic adaptation to habitat in wild chimpanzees. Ostridge, Harrison J Fontsere, Claudia Lizano, Esther Soto, Daniela C Schmidt, Joshua M Saxena, Vrishti Alvarez-Estape, Marina Barratt, Christopher D Gratton, Paolo Bocksberger, Gaëlle Lester, Jack D Dieguez, Paula Agbor, Anthony Angedakin, Samuel Assumang, Alfred Kwabena Bailey, Emma Barubiyo, Donatienne Bessone, Mattia Brazzola, Gregory Chancellor, Rebecca Cohen, Heather Coupland, Charlotte Danquah, Emmanuel Deschner, Tobias Dotras, Laia Dupain, Jef Egbe, Villard Ebot Granjon, Anne-Céline Head, Josephine Hedwig, Daniela Hermans, Veerle Hernandez-Aguilar, R Adriana Jeffery, Kathryn J Jones, Sorrel Junker, Jessica Kadam, Parag Kaiser, Michael Kalan, Ammie K Kambere, Mbangi Kienast, Ivonne Kujirakwinja, Deo Langergraber, Kevin E Lapuente, Juan Larson, Bradley Laudisoit, Anne Lee, Kevin C Llana, Manuel Maretti, Giovanna Martín, Rumen Meier, Amelia C Morgan, David Neil, Emily Nicholl, Sonia Nixon, Stuart Normand, Emmanuelle Orbell, Christopher Ormsby, Lucy Jayne Orume, Robinson Pacheco, Liliana Preece, Jodie Regnaut, Sebastien Robbins, Martha M Rundus, Aaron Sanz, Crickette Sciaky, Lilah Sommer, Volker Stewart, Fiona A Tagg, Nikki Tédonzong, Luc Roscelin van Schijndel, Joost Vendras, Elleni Wessling, Erin G Willie, Jacob Wittig, Roman M Yuh, Yisa Ginath Yurkiw, Kyle Vigilant, Linda Piel, Alex K Boesch, Christophe Kühl, Hjalmar S Dennis, Megan Y Marques-Bonet, Tomas Arandjelovic, Mimi Andrés, Aida M Animals Adaptation, Physiological Ecosystem Endangered Species Genetic Variation Malaria Pan troglodytes Selection, Genetic Population Genomics How populations adapt to their environment is a fundamental question in biology. Yet, we know surprisingly little about this process, especially for endangered species, such as nonhuman great apes. Chimpanzees, our closest living relatives, are particularly notable because they inhabit diverse habitats, from rainforest to woodland-savannah. Whether genetic adaptation facilitates such habitat diversity remains unknown, despite it having wide implications for evolutionary biology and conservation. By using newly sequenced exomes from 828 wild chimpanzees (388 postfiltering), we found evidence of fine-scale genetic adaptation to habitat, with signatures of positive selection in forest chimpanzees in the same genes underlying adaptation to malaria in humans. This work demonstrates the power of noninvasive samples to reveal genetic adaptations in endangered populations and highlights the importance of adaptive genetic diversity for chimpanzees. |
| title | Local genetic adaptation to habitat in wild chimpanzees. |
| topic | Animals Adaptation, Physiological Ecosystem Endangered Species Genetic Variation Malaria Pan troglodytes Selection, Genetic Population Genomics |
| url | https://pubmed.ncbi.nlm.nih.gov/41296989/ |