Therapeutic Evaluation of Alginate from Brown Seaweeds: A Comparative Study of and .
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| Autori principali: | , , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Pharmaceuticals (Basel, Switzerland)
2025
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| _version_ | 1868266119902527489 |
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| author | El-Sheekh, Mostafa M Bases, Eman El Shafay, Shimaa M El-Shenody, Rania A Elshobary, Mostafa E Abdel Wahab, Abdel Hady A Yousuf, Wesam E Essa, Dorya I Alkafaas, Samar Sami |
| author_facet | El-Sheekh, Mostafa M Bases, Eman El Shafay, Shimaa M El-Shenody, Rania A Elshobary, Mostafa E Abdel Wahab, Abdel Hady A Yousuf, Wesam E Essa, Dorya I Alkafaas, Samar Sami El-Sheekh, Mostafa M Bases, Eman El Shafay, Shimaa M El-Shenody, Rania A Elshobary, Mostafa E Abdel Wahab, Abdel Hady A Yousuf, Wesam E Essa, Dorya I Alkafaas, Samar Sami |
| collection | PubMed - marine biology |
| contents | Therapeutic Evaluation of Alginate from Brown Seaweeds: A Comparative Study of and . El-Sheekh, Mostafa M Bases, Eman El Shafay, Shimaa M El-Shenody, Rania A Elshobary, Mostafa E Abdel Wahab, Abdel Hady A Yousuf, Wesam E Essa, Dorya I Alkafaas, Samar Sami Alginate is a naturally occurring anionic polysaccharide extracted from brown marine algae and widely explored for biomedical applications due to its biocompatibility and functional versatility. This study aims to extract and compare alginates from two Red Sea brown algae, (TA) and (HA), and to evaluate how structural differences influence their therapeutic properties. Alginate was isolated by sequential acid-alkaline extraction and characterized using FTIR, XRD, TGA, elemental analysis, and HPLC. Biological activities were assessed through antioxidant, anti-inflammatory, antidiabetic, neuroprotective, and hepatoprotective assays, supported by molecular docking and gene ontology interaction analysis. Distinct physicochemical variations were observed between HA and TA. TA exhibited stronger antioxidant (IC = 25.89 µg/mL), anti-inflammatory (COX-1 IC = 69.61 µg/mL), antidiabetic (α-amylase IC = 45.14 µg/mL), and hepatoprotective activities (IC = 118.21 µg/mL), whereas HA displayed superior neuroprotective potential through butyrylcholinesterase inhibition (IC = 39.01 µg/mL). Molecular docking supported the in vitro findings by confirming interactions with key protein targets associated with oxidative stress and metabolic pathways. Structural variation between species-derived alginates directly impacts their biological activities. TA represents a promising candidate for metabolic and anti-inflammatory therapies, while HA may be more suitable for neuroprotective interventions. These results emphasize the importance of source-specific alginate selection for developing targeted pharmaceutical applications. |
| format | Artículo científico |
| id | pubmed_41304964 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Pharmaceuticals (Basel, Switzerland) |
| record_format | pubmed |
| spellingShingle | Therapeutic Evaluation of Alginate from Brown Seaweeds: A Comparative Study of and . El-Sheekh, Mostafa M Bases, Eman El Shafay, Shimaa M El-Shenody, Rania A Elshobary, Mostafa E Abdel Wahab, Abdel Hady A Yousuf, Wesam E Essa, Dorya I Alkafaas, Samar Sami Therapeutic Evaluation of Alginate from Brown Seaweeds: A Comparative Study of and . El-Sheekh, Mostafa M Bases, Eman El Shafay, Shimaa M El-Shenody, Rania A Elshobary, Mostafa E Abdel Wahab, Abdel Hady A Yousuf, Wesam E Essa, Dorya I Alkafaas, Samar Sami Alginate is a naturally occurring anionic polysaccharide extracted from brown marine algae and widely explored for biomedical applications due to its biocompatibility and functional versatility. This study aims to extract and compare alginates from two Red Sea brown algae, (TA) and (HA), and to evaluate how structural differences influence their therapeutic properties. Alginate was isolated by sequential acid-alkaline extraction and characterized using FTIR, XRD, TGA, elemental analysis, and HPLC. Biological activities were assessed through antioxidant, anti-inflammatory, antidiabetic, neuroprotective, and hepatoprotective assays, supported by molecular docking and gene ontology interaction analysis. Distinct physicochemical variations were observed between HA and TA. TA exhibited stronger antioxidant (IC = 25.89 µg/mL), anti-inflammatory (COX-1 IC = 69.61 µg/mL), antidiabetic (α-amylase IC = 45.14 µg/mL), and hepatoprotective activities (IC = 118.21 µg/mL), whereas HA displayed superior neuroprotective potential through butyrylcholinesterase inhibition (IC = 39.01 µg/mL). Molecular docking supported the in vitro findings by confirming interactions with key protein targets associated with oxidative stress and metabolic pathways. Structural variation between species-derived alginates directly impacts their biological activities. TA represents a promising candidate for metabolic and anti-inflammatory therapies, while HA may be more suitable for neuroprotective interventions. These results emphasize the importance of source-specific alginate selection for developing targeted pharmaceutical applications. |
| title | Therapeutic Evaluation of Alginate from Brown Seaweeds: A Comparative Study of and . |
| url | https://pubmed.ncbi.nlm.nih.gov/41304964/ |