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| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine life science & technology
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41322276/ |
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| _version_ | 1868266119875264514 |
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| author | Ding, Wenjuan Li, Xiaobin Wang, Xiyue Yu, Shuqing Li, Xunuo Wang, FangFang Tian, Danmei Wu, Bin Tang, Jinshan |
| author_facet | Ding, Wenjuan Li, Xiaobin Wang, Xiyue Yu, Shuqing Li, Xunuo Wang, FangFang Tian, Danmei Wu, Bin Tang, Jinshan Ding, Wenjuan Li, Xiaobin Wang, Xiyue Yu, Shuqing Li, Xunuo Wang, FangFang Tian, Danmei Wu, Bin Tang, Jinshan |
| collection | PubMed - marine biology |
| contents | Sesquiterpenoids from the hydrothermal vent sediment derived fungus sp. JWM79-5-1 with antithrombotic and pro-angiogenic activities. Ding, Wenjuan Li, Xiaobin Wang, Xiyue Yu, Shuqing Li, Xunuo Wang, FangFang Tian, Danmei Wu, Bin Tang, Jinshan Seven previously unreported sesquiterpenes including three rare 5/5/6-fused tricyclic gymnomitrane-type sesquiterpenes (-), an -longipinane-type sesquiterpene (), a cuparane-type sesquiterpene (), and two chamigrane-type sesquiterpenes ( and ), along with a known chamigrane-type sesquiterpene xylariterpenoid C () were isolated from the hydrothermal vent sediment derived fungus sp. JWM79-5-1. Their structures were identified on the basis of 1D and 2D NMR, in conjunction with Mosher's method, X-ray crystallography, and electronic circular dichroism (ECD). The antithrombotic activity of compounds - and was evaluated in arachidonic acid (AA)-induced zebrafish thrombosis model in vivo The results revealed compound with potent antithrombotic activity in a concentration-dependent manner. Further, the pro-angiogenic activities of compounds - and were evaluated in a transgenic zebrafish model that expresses , the receptor for the angiogenic factor VEGF, tagged with the green fluorescence protein (-GFP) through detecting the length of both intersegmental vessels (ISVs) and subintestinal veins (SIVs). The results revealed that compound exhibited a potent antithrombotic activity while revealed a potent pro-angiogenic activity. These findings strongly support drug development of these compounds in cardiovascular disease treatment. The online version contains supplementary material available at 10.1007/s42995-025-00303-y. |
| format | Artículo científico |
| id | pubmed_41322276 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Marine life science & technology |
| record_format | pubmed |
| spellingShingle | Sesquiterpenoids from the hydrothermal vent sediment derived fungus sp. JWM79-5-1 with antithrombotic and pro-angiogenic activities. Ding, Wenjuan Li, Xiaobin Wang, Xiyue Yu, Shuqing Li, Xunuo Wang, FangFang Tian, Danmei Wu, Bin Tang, Jinshan Sesquiterpenoids from the hydrothermal vent sediment derived fungus sp. JWM79-5-1 with antithrombotic and pro-angiogenic activities. Ding, Wenjuan Li, Xiaobin Wang, Xiyue Yu, Shuqing Li, Xunuo Wang, FangFang Tian, Danmei Wu, Bin Tang, Jinshan Seven previously unreported sesquiterpenes including three rare 5/5/6-fused tricyclic gymnomitrane-type sesquiterpenes (-), an -longipinane-type sesquiterpene (), a cuparane-type sesquiterpene (), and two chamigrane-type sesquiterpenes ( and ), along with a known chamigrane-type sesquiterpene xylariterpenoid C () were isolated from the hydrothermal vent sediment derived fungus sp. JWM79-5-1. Their structures were identified on the basis of 1D and 2D NMR, in conjunction with Mosher's method, X-ray crystallography, and electronic circular dichroism (ECD). The antithrombotic activity of compounds - and was evaluated in arachidonic acid (AA)-induced zebrafish thrombosis model in vivo The results revealed compound with potent antithrombotic activity in a concentration-dependent manner. Further, the pro-angiogenic activities of compounds - and were evaluated in a transgenic zebrafish model that expresses , the receptor for the angiogenic factor VEGF, tagged with the green fluorescence protein (-GFP) through detecting the length of both intersegmental vessels (ISVs) and subintestinal veins (SIVs). The results revealed that compound exhibited a potent antithrombotic activity while revealed a potent pro-angiogenic activity. These findings strongly support drug development of these compounds in cardiovascular disease treatment. The online version contains supplementary material available at 10.1007/s42995-025-00303-y. |
| title | Sesquiterpenoids from the hydrothermal vent sediment derived fungus sp. JWM79-5-1 with antithrombotic and pro-angiogenic activities. |
| url | https://pubmed.ncbi.nlm.nih.gov/41322276/ |