Anti-acne potential of : GC-MS profiling and antibacterial activity of n-hexadecanoic acid and α-tocopherol.
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| Autori principali: | , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Journal of advanced veterinary and animal research
2025
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| Accesso online: | |
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| author | Hudaidah, Siti Amiin, Muhammad Kholiqul Winanti, Diki Danar Tri Yusup, Maulid Wahid Rivaie, Arief Rahman Samara, Syifania Hanifah Sari, Linda Ratna Susanto, Gregorius Nugroho |
| author_facet | Hudaidah, Siti Amiin, Muhammad Kholiqul Winanti, Diki Danar Tri Yusup, Maulid Wahid Rivaie, Arief Rahman Samara, Syifania Hanifah Sari, Linda Ratna Susanto, Gregorius Nugroho Hudaidah, Siti Amiin, Muhammad Kholiqul Winanti, Diki Danar Tri Yusup, Maulid Wahid Rivaie, Arief Rahman Samara, Syifania Hanifah Sari, Linda Ratna Susanto, Gregorius Nugroho |
| collection | PubMed - marine biology |
| contents | Anti-acne potential of : GC-MS profiling and antibacterial activity of n-hexadecanoic acid and α-tocopherol. Hudaidah, Siti Amiin, Muhammad Kholiqul Winanti, Diki Danar Tri Yusup, Maulid Wahid Rivaie, Arief Rahman Samara, Syifania Hanifah Sari, Linda Ratna Susanto, Gregorius Nugroho This study explores the bioactive compounds in and their potential as anti-acne agents through gas chromatography-mass spectrometry (GC-MS) analysis and disc diffusion assays. 3.3 gm of . was extracted and tested against three acne-causing pathogens: , , and , under varying extract concentrations. The GC-MS analysis detected several bioactive compounds in the extract, including fatty acids (e.g., n-hexadecanoic acid and linoleic acid esters), polysaccharides, vitamins, aromatic compounds, and diterpenoids. Fatty acids and vitamin compounds dominated, comprising 72.20% of the extract, with alpha-tocopherol and its derivatives as prominent components. Antimicrobial activity was assessed using the disc-diffusion method. The extract demonstrated notable antibacterial effects, particularly at 10 ppm, achieving inhibition zones of 18.0 ± 2.0 mm against . , 19.9 ± 1.7 mm against , and 19.5 ± 4.7 mm against . . These zones of inhibition were classified as intermediate. The results indicate that microalgae from the Chlorophyceae class are more effective against Gram-positive than Gram-negative bacteria. These findings emphasize the potential of bioactive compounds as anti-acne agents, suggesting they could serve as substitutes for antibiotics. |
| format | Artículo científico |
| id | pubmed_41328237 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of advanced veterinary and animal research |
| record_format | pubmed |
| spellingShingle | Anti-acne potential of : GC-MS profiling and antibacterial activity of n-hexadecanoic acid and α-tocopherol. Hudaidah, Siti Amiin, Muhammad Kholiqul Winanti, Diki Danar Tri Yusup, Maulid Wahid Rivaie, Arief Rahman Samara, Syifania Hanifah Sari, Linda Ratna Susanto, Gregorius Nugroho Anti-acne potential of : GC-MS profiling and antibacterial activity of n-hexadecanoic acid and α-tocopherol. Hudaidah, Siti Amiin, Muhammad Kholiqul Winanti, Diki Danar Tri Yusup, Maulid Wahid Rivaie, Arief Rahman Samara, Syifania Hanifah Sari, Linda Ratna Susanto, Gregorius Nugroho This study explores the bioactive compounds in and their potential as anti-acne agents through gas chromatography-mass spectrometry (GC-MS) analysis and disc diffusion assays. 3.3 gm of . was extracted and tested against three acne-causing pathogens: , , and , under varying extract concentrations. The GC-MS analysis detected several bioactive compounds in the extract, including fatty acids (e.g., n-hexadecanoic acid and linoleic acid esters), polysaccharides, vitamins, aromatic compounds, and diterpenoids. Fatty acids and vitamin compounds dominated, comprising 72.20% of the extract, with alpha-tocopherol and its derivatives as prominent components. Antimicrobial activity was assessed using the disc-diffusion method. The extract demonstrated notable antibacterial effects, particularly at 10 ppm, achieving inhibition zones of 18.0 ± 2.0 mm against . , 19.9 ± 1.7 mm against , and 19.5 ± 4.7 mm against . . These zones of inhibition were classified as intermediate. The results indicate that microalgae from the Chlorophyceae class are more effective against Gram-positive than Gram-negative bacteria. These findings emphasize the potential of bioactive compounds as anti-acne agents, suggesting they could serve as substitutes for antibiotics. |
| title | Anti-acne potential of : GC-MS profiling and antibacterial activity of n-hexadecanoic acid and α-tocopherol. |
| url | https://pubmed.ncbi.nlm.nih.gov/41328237/ |