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| Main Authors: | , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Bioorganic chemistry
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41330119/ |
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| _version_ | 1868266117069275137 |
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| author | Hu, Xue-Yi Li, Xiao-Ming Li, Xin Wang, Bin-Gui Meng, Ling-Hong |
| author_facet | Hu, Xue-Yi Li, Xiao-Ming Li, Xin Wang, Bin-Gui Meng, Ling-Hong Hu, Xue-Yi Li, Xiao-Ming Li, Xin Wang, Bin-Gui Meng, Ling-Hong |
| collection | PubMed - marine biology |
| contents | Genome analysis-led discovery of antimicrobial and herbicidal cytochalasans from the cold-seep-sourced endozoic Curvularia verruculosa CS-129. Hu, Xue-Yi Li, Xiao-Ming Li, Xin Wang, Bin-Gui Meng, Ling-Hong Microbial Sensitivity Tests Curvularia Cytochalasins Dose-Response Relationship, Drug Anti-Bacterial Agents Molecular Structure Structure-Activity Relationship Drug Discovery Animals Cytochalasans are abundant in structural diversity and potent in biological activities. Here, after the genome analysis of Curvularia verruculosa and by adding NaS and NaSO to rice medium based on one strain-many compounds (OSMAC) strategy, we obtained and describe the characterization of six previously undescribed cytochalasans (1-6) from marine endozoic fungus Curvularia verruculosa CS-129 which was isolated from the inner fresh tissue of the deep-sea squat lobster Shinkaia crosnieri collected from the cold-seep area of the South China Sea. Among them, vercytoaspochalasin A (1) represents the first reported aspochalasin (cytochalasans biosynthesized by leucine) combining a 14-membered macrolide, while compound 3 is the first reported cytochalasan with an iodine substituent group and 20-methoxycytochalasin B γ-lactone (6) is a rare macrocyclic ring-opening natural cytochalasin coupled with a furan ring. Compounds 2, 5, 7, and 8 demonstrated differential antimicrobial efficacy against both aquatic-pathogenic bacteria and plant-pathogenic fungi with varying potency. In addition, compounds 5 and 7 could significantly inhibit the radicle growth of Amaranthus retroflexus seedlings with a dose-dependent relationship. |
| format | Artículo científico |
| id | pubmed_41330119 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Bioorganic chemistry |
| record_format | pubmed |
| spellingShingle | Genome analysis-led discovery of antimicrobial and herbicidal cytochalasans from the cold-seep-sourced endozoic Curvularia verruculosa CS-129. Hu, Xue-Yi Li, Xiao-Ming Li, Xin Wang, Bin-Gui Meng, Ling-Hong Microbial Sensitivity Tests Curvularia Cytochalasins Dose-Response Relationship, Drug Anti-Bacterial Agents Molecular Structure Structure-Activity Relationship Drug Discovery Animals Genome analysis-led discovery of antimicrobial and herbicidal cytochalasans from the cold-seep-sourced endozoic Curvularia verruculosa CS-129. Hu, Xue-Yi Li, Xiao-Ming Li, Xin Wang, Bin-Gui Meng, Ling-Hong Microbial Sensitivity Tests Curvularia Cytochalasins Dose-Response Relationship, Drug Anti-Bacterial Agents Molecular Structure Structure-Activity Relationship Drug Discovery Animals Cytochalasans are abundant in structural diversity and potent in biological activities. Here, after the genome analysis of Curvularia verruculosa and by adding NaS and NaSO to rice medium based on one strain-many compounds (OSMAC) strategy, we obtained and describe the characterization of six previously undescribed cytochalasans (1-6) from marine endozoic fungus Curvularia verruculosa CS-129 which was isolated from the inner fresh tissue of the deep-sea squat lobster Shinkaia crosnieri collected from the cold-seep area of the South China Sea. Among them, vercytoaspochalasin A (1) represents the first reported aspochalasin (cytochalasans biosynthesized by leucine) combining a 14-membered macrolide, while compound 3 is the first reported cytochalasan with an iodine substituent group and 20-methoxycytochalasin B γ-lactone (6) is a rare macrocyclic ring-opening natural cytochalasin coupled with a furan ring. Compounds 2, 5, 7, and 8 demonstrated differential antimicrobial efficacy against both aquatic-pathogenic bacteria and plant-pathogenic fungi with varying potency. In addition, compounds 5 and 7 could significantly inhibit the radicle growth of Amaranthus retroflexus seedlings with a dose-dependent relationship. |
| title | Genome analysis-led discovery of antimicrobial and herbicidal cytochalasans from the cold-seep-sourced endozoic Curvularia verruculosa CS-129. |
| topic | Microbial Sensitivity Tests Curvularia Cytochalasins Dose-Response Relationship, Drug Anti-Bacterial Agents Molecular Structure Structure-Activity Relationship Drug Discovery Animals |
| url | https://pubmed.ncbi.nlm.nih.gov/41330119/ |