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| Autores principales: | , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Phytochemistry
2026
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/41330446/ |
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| _version_ | 1868266117068226561 |
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| author | Feng, Xing-Yan Yang, Sui-Qun Li, Xiao-Ming Li, Xin Wang, Bin-Gui Meng, Ling-Hong |
| author_facet | Feng, Xing-Yan Yang, Sui-Qun Li, Xiao-Ming Li, Xin Wang, Bin-Gui Meng, Ling-Hong Feng, Xing-Yan Yang, Sui-Qun Li, Xiao-Ming Li, Xin Wang, Bin-Gui Meng, Ling-Hong |
| collection | PubMed - marine biology |
| contents | Antifungal phenolic glucosides and related congeners from the cold-seep-derived Talaromyces trachyspermus CS-106. Feng, Xing-Yan Yang, Sui-Qun Li, Xiao-Ming Li, Xin Wang, Bin-Gui Meng, Ling-Hong Talaromyces Fusarium Microbial Sensitivity Tests Phenols Antifungal Agents Glucosides Alternaria Molecular Structure Molecular Docking Simulation Colletotrichum Structure-Activity Relationship Solanum lycopersicum Chemical investigation of the cold-seep-sourced fungus Talaromyces trachyspermus CS-106 resulted in the isolation of six previously undescribed phenolic glucopyranosides, talarosides A-F (1-6), two previously undescribed phenolic cysteine derivatives, talacysteines A and B (7 and 8), and five known congeners 9-13. The results from in vitro bioassay indicated that compounds 3, 6, and 9 displayed potent activities against several tested phytopathogenic fungal strains. Specially, the chloroquinone derivative, 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione (compound 9), exhibited a broad spectrum of fungicidal activity against Alternaria brassicae, Colletotrichum gloeosporioides, Fusarium graminearum, and F. oxysporum, with MIC values ranging from 0.5 to 4 μg/mL. In vivo testing on tomato fruits showed that 9 displayed considerable curative efficacy against F. oxysporum. Both scanning electron microscopy and cryo-SEM analysis indicated that 9 possessed a strong ability to destroy the surface morphology of mycelia and seriously interfere with the growth of the fungal pathogen. Compound 9 also exhibited pronounced succinate dehydrogenase (SDH) inhibitory activity from the in vitro SDH inhibitory assay. Molecular docking simulations were performed to explore the intermolecular interaction of 9 with SDH enzyme from F. oxysporum. These findings presented a promising lead compound such as compound 9 for the discovery of SDH inhibitor as antifungal agents. |
| format | Artículo científico |
| id | pubmed_41330446 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Phytochemistry |
| record_format | pubmed |
| spellingShingle | Antifungal phenolic glucosides and related congeners from the cold-seep-derived Talaromyces trachyspermus CS-106. Feng, Xing-Yan Yang, Sui-Qun Li, Xiao-Ming Li, Xin Wang, Bin-Gui Meng, Ling-Hong Talaromyces Fusarium Microbial Sensitivity Tests Phenols Antifungal Agents Glucosides Alternaria Molecular Structure Molecular Docking Simulation Colletotrichum Structure-Activity Relationship Solanum lycopersicum Antifungal phenolic glucosides and related congeners from the cold-seep-derived Talaromyces trachyspermus CS-106. Feng, Xing-Yan Yang, Sui-Qun Li, Xiao-Ming Li, Xin Wang, Bin-Gui Meng, Ling-Hong Talaromyces Fusarium Microbial Sensitivity Tests Phenols Antifungal Agents Glucosides Alternaria Molecular Structure Molecular Docking Simulation Colletotrichum Structure-Activity Relationship Solanum lycopersicum Chemical investigation of the cold-seep-sourced fungus Talaromyces trachyspermus CS-106 resulted in the isolation of six previously undescribed phenolic glucopyranosides, talarosides A-F (1-6), two previously undescribed phenolic cysteine derivatives, talacysteines A and B (7 and 8), and five known congeners 9-13. The results from in vitro bioassay indicated that compounds 3, 6, and 9 displayed potent activities against several tested phytopathogenic fungal strains. Specially, the chloroquinone derivative, 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione (compound 9), exhibited a broad spectrum of fungicidal activity against Alternaria brassicae, Colletotrichum gloeosporioides, Fusarium graminearum, and F. oxysporum, with MIC values ranging from 0.5 to 4 μg/mL. In vivo testing on tomato fruits showed that 9 displayed considerable curative efficacy against F. oxysporum. Both scanning electron microscopy and cryo-SEM analysis indicated that 9 possessed a strong ability to destroy the surface morphology of mycelia and seriously interfere with the growth of the fungal pathogen. Compound 9 also exhibited pronounced succinate dehydrogenase (SDH) inhibitory activity from the in vitro SDH inhibitory assay. Molecular docking simulations were performed to explore the intermolecular interaction of 9 with SDH enzyme from F. oxysporum. These findings presented a promising lead compound such as compound 9 for the discovery of SDH inhibitor as antifungal agents. |
| title | Antifungal phenolic glucosides and related congeners from the cold-seep-derived Talaromyces trachyspermus CS-106. |
| topic | Talaromyces Fusarium Microbial Sensitivity Tests Phenols Antifungal Agents Glucosides Alternaria Molecular Structure Molecular Docking Simulation Colletotrichum Structure-Activity Relationship Solanum lycopersicum |
| url | https://pubmed.ncbi.nlm.nih.gov/41330446/ |