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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Communications biology
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41339710/ |
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| _version_ | 1868266117050400769 |
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| author | Pacheco-Valenciana, Armando Tausch, Anna Veseli, Iva Dharamshi, Jennah E Bergland, Fabian Delgado, Luis F Rodríguez-Gijón, Alejandro Andersson, Anders F Garcia, Sarahi L |
| author_facet | Pacheco-Valenciana, Armando Tausch, Anna Veseli, Iva Dharamshi, Jennah E Bergland, Fabian Delgado, Luis F Rodríguez-Gijón, Alejandro Andersson, Anders F Garcia, Sarahi L Pacheco-Valenciana, Armando Tausch, Anna Veseli, Iva Dharamshi, Jennah E Bergland, Fabian Delgado, Luis F Rodríguez-Gijón, Alejandro Andersson, Anders F Garcia, Sarahi L |
| collection | PubMed - marine biology |
| contents | Microbial model communities exhibit widespread metabolic interdependencies. Pacheco-Valenciana, Armando Tausch, Anna Veseli, Iva Dharamshi, Jennah E Bergland, Fabian Delgado, Luis F Rodríguez-Gijón, Alejandro Andersson, Anders F Garcia, Sarahi L Bacteria Metagenome Microbiota Genome, Bacterial Seawater Phylogeny Microorganisms thrive in complex communities shaped by intricate interactions, yet the extent and ecological implications of biosynthetic dependencies in natural communities remain underexplored. Here, we used a dilution approach to cultivate 204 microbial model communities from the Baltic Sea and recovered 527 metagenome-assembled genomes (MAGs) that dereplicated into 72 species-clusters (>95% average nucleotide identity, ANI). Of these species, at least 70% represent previously uncultivated lineages. Combined with 1073 MAGs from Baltic Sea metagenomes, we generated a genomic catalog of 701 species-clusters. Our results show that cultures with more than three species included microorganisms with smaller genome sizes, lower biosynthetic potential for amino acids and B vitamins, and higher prevalence and abundance in the environment. Moreover, the taxa found together in the same model communities had complementary biosynthetic gene repertoires. Our results demonstrate that cultivating bacteria in dilution model communities facilitates access to previously uncultivated but abundant species that likely depend on metabolic partners for survival. Together, our findings highlight the value of community-based cultivation for unraveling ecological strategies. Finally, we confirm that metabolic interdependencies and genome streamlining are widespread features of successful environmental microorganisms. |
| format | Artículo científico |
| id | pubmed_41339710 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Communications biology |
| record_format | pubmed |
| spellingShingle | Microbial model communities exhibit widespread metabolic interdependencies. Pacheco-Valenciana, Armando Tausch, Anna Veseli, Iva Dharamshi, Jennah E Bergland, Fabian Delgado, Luis F Rodríguez-Gijón, Alejandro Andersson, Anders F Garcia, Sarahi L Bacteria Metagenome Microbiota Genome, Bacterial Seawater Phylogeny Microbial model communities exhibit widespread metabolic interdependencies. Pacheco-Valenciana, Armando Tausch, Anna Veseli, Iva Dharamshi, Jennah E Bergland, Fabian Delgado, Luis F Rodríguez-Gijón, Alejandro Andersson, Anders F Garcia, Sarahi L Bacteria Metagenome Microbiota Genome, Bacterial Seawater Phylogeny Microorganisms thrive in complex communities shaped by intricate interactions, yet the extent and ecological implications of biosynthetic dependencies in natural communities remain underexplored. Here, we used a dilution approach to cultivate 204 microbial model communities from the Baltic Sea and recovered 527 metagenome-assembled genomes (MAGs) that dereplicated into 72 species-clusters (>95% average nucleotide identity, ANI). Of these species, at least 70% represent previously uncultivated lineages. Combined with 1073 MAGs from Baltic Sea metagenomes, we generated a genomic catalog of 701 species-clusters. Our results show that cultures with more than three species included microorganisms with smaller genome sizes, lower biosynthetic potential for amino acids and B vitamins, and higher prevalence and abundance in the environment. Moreover, the taxa found together in the same model communities had complementary biosynthetic gene repertoires. Our results demonstrate that cultivating bacteria in dilution model communities facilitates access to previously uncultivated but abundant species that likely depend on metabolic partners for survival. Together, our findings highlight the value of community-based cultivation for unraveling ecological strategies. Finally, we confirm that metabolic interdependencies and genome streamlining are widespread features of successful environmental microorganisms. |
| title | Microbial model communities exhibit widespread metabolic interdependencies. |
| topic | Bacteria Metagenome Microbiota Genome, Bacterial Seawater Phylogeny |
| url | https://pubmed.ncbi.nlm.nih.gov/41339710/ |