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| Main Authors: | , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Nutrition research reviews
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41340293/ |
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| _version_ | 1868266117048303617 |
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| author | Yildiz, Cennet Akpınaroğlu, Can Medina, Isabel |
| author_facet | Yildiz, Cennet Akpınaroğlu, Can Medina, Isabel Yildiz, Cennet Akpınaroğlu, Can Medina, Isabel |
| collection | PubMed - marine biology |
| contents | Unravelling the nutritional threads with novel associations of cognitive functions and telomerase. Yildiz, Cennet Akpınaroğlu, Can Medina, Isabel Humans Telomerase Cognition Fatty Acids, Omega-3 Cognitive Dysfunction Oxidative Stress Brain Aging Docosahexaenoic Acids Telomere Diet Biomarkers Eicosapentaenoic Acid Cognitive decline is a hallmark of brain ageing. Leucocyte telomere length (LTL) has emerged as a candidate biomarker related to brain ageing and neurodegeneration; however, reported associations with cognition and brain structure vary across cohorts. Long-chain omega-3 polyunsaturated fatty acids (PUFA), notably docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), exert anti-inflammatory and antioxidant effects that may, in some contexts, relate to slower telomere attrition. Here, we synthesise evidence on -3 PUFA, telomere biology and cognitive outcomes, integrating clinical, epidemiologic and experimental data. We emphasise biological plausibility (oxidative stress/inflammation, membrane remodelling, mitochondrial function and expression of telomerase reverse transcriptase (TERT) through PI3K/Akt/mTOR, NRF2 and epigenetic modifications) while acknowledging heterogeneous human findings and methodological considerations (assay variability, life-course timing, cognitive domains and biomarker stratification). We outline priorities for future studies to clarify causal pathways and inform dietary strategies that support healthy cognitive ageing. |
| format | Artículo científico |
| id | pubmed_41340293 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Nutrition research reviews |
| record_format | pubmed |
| spellingShingle | Unravelling the nutritional threads with novel associations of cognitive functions and telomerase. Yildiz, Cennet Akpınaroğlu, Can Medina, Isabel Humans Telomerase Cognition Fatty Acids, Omega-3 Cognitive Dysfunction Oxidative Stress Brain Aging Docosahexaenoic Acids Telomere Diet Biomarkers Eicosapentaenoic Acid Unravelling the nutritional threads with novel associations of cognitive functions and telomerase. Yildiz, Cennet Akpınaroğlu, Can Medina, Isabel Humans Telomerase Cognition Fatty Acids, Omega-3 Cognitive Dysfunction Oxidative Stress Brain Aging Docosahexaenoic Acids Telomere Diet Biomarkers Eicosapentaenoic Acid Cognitive decline is a hallmark of brain ageing. Leucocyte telomere length (LTL) has emerged as a candidate biomarker related to brain ageing and neurodegeneration; however, reported associations with cognition and brain structure vary across cohorts. Long-chain omega-3 polyunsaturated fatty acids (PUFA), notably docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), exert anti-inflammatory and antioxidant effects that may, in some contexts, relate to slower telomere attrition. Here, we synthesise evidence on -3 PUFA, telomere biology and cognitive outcomes, integrating clinical, epidemiologic and experimental data. We emphasise biological plausibility (oxidative stress/inflammation, membrane remodelling, mitochondrial function and expression of telomerase reverse transcriptase (TERT) through PI3K/Akt/mTOR, NRF2 and epigenetic modifications) while acknowledging heterogeneous human findings and methodological considerations (assay variability, life-course timing, cognitive domains and biomarker stratification). We outline priorities for future studies to clarify causal pathways and inform dietary strategies that support healthy cognitive ageing. |
| title | Unravelling the nutritional threads with novel associations of cognitive functions and telomerase. |
| topic | Humans Telomerase Cognition Fatty Acids, Omega-3 Cognitive Dysfunction Oxidative Stress Brain Aging Docosahexaenoic Acids Telomere Diet Biomarkers Eicosapentaenoic Acid |
| url | https://pubmed.ncbi.nlm.nih.gov/41340293/ |