Multiscale structure of chromatin condensates explains phase separation and material properties.

Fuente: PubMed

Salvato in:

Dettagli Bibliografici
Autori principali:	Zhou, Huabin, Huertas, Jan, Maristany, M Julia, Russell, Kieran, Hwang, June Ho, Yao, Run-Wen, Samanta, Nirnay, Hutchings, Joshua, Billur, Ramya, Shiozaki, Momoko, Zhao, Xiaowei, Doolittle, Lynda K, Gibson, Bryan A, Soranno, Andrea, Riggi, Margot, Espinosa, Jorge R, Yu, Zhiheng, Villa, Elizabeth, Collepardo-Guevara, Rosana, Rosen, Michael K
Natura:	Artículo científico
Lingua:	en
Pubblicazione:	Science (New York, N.Y.) 2025
Soggetti:	Nucleosomes Molecular Dynamics Simulation Cryoelectron Microscopy Chromatin Histones Electron Microscope Tomography DNA Animals Biomolecular Condensates Humans Thermodynamics Phase Separation
Accesso online:	Acceder al recurso
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!

Documenti analoghi

Nucleosome spacing can fine-tune higher-order chromatin assembly.
di: Chen, Lifeng, et al.
Pubblicazione: (2025)

Bromodomain protein IBD1 bridges histone acetylation and H2A.Z deposition to fine-tune transcription.
di: Zhang, Zhe, et al.
Pubblicazione: (2026)

Heterochromatin-dependent transcription links the PRC2 complex to small RNA-mediated DNA elimination.
di: Solberg, Therese, et al.
Pubblicazione: (2025)

Supplementary data for "The histone code of love: epigenetics of maturation of gonads in the human blood fluke Schistosoma mansoni"
di: Grunau, Christoph
Pubblicazione: (2026)

H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs.
di: Krug, Brian, et al.
Pubblicazione: (2026)

Af-CUT&Tag: a sensitive and antibody-free chromatin profiling method using genetically encoded tags and high-affinity binders fused to Tn5.
di: Wang, Xindong, et al.
Pubblicazione: (2026)

JINEPT: Controlling Evolution
di: Lim, Suzanne
Pubblicazione: (2025)

Comunicación interauricular evaluada por resonancia magnética cardiovascular: comparación con ecocardiografía Doppler
di: Ricardo Obregón
Pubblicazione: (2007)

Emerging oligo-based imaging methods to study chromatin organization in cells and tissue.
di: Bouwman, Britta Am, et al.
Pubblicazione: (2026)

Differences in chromatin accessibility and gene expression associated with growth performance in Pacific whiteleg shrimp, Litopenaeus vannamei.
di: Ma, Bo, et al.
Pubblicazione: (2026)

Toxicological evaluation of different pesticides in Tetragonisca angustula Latreille (Hymenoptera, Apidae)
di: Ana Lúcia Paz Barateiro Stuchi
Pubblicazione: (2023)

Magnetic surface flux data and spatial information of magnetic grains from a Hawaiian lava and results of using this data for Micromagnetic Tomography
di: Kosters, Martha E, et al.
Pubblicazione: (2023)

Comparative toxicity of fipronil, malathion, and thiamethoxam on the stingless bee Tetragonisca fiebrigi (Schwarz, 1938)
di: Ana Lúcia Paz Barateiro Stuchi
Pubblicazione: (2022)

The descending branch of the lateral femoral circumflex artery is a good option in CABG with arterial grafts
di: Fábio Antonio Gaiotto
Pubblicazione: (2013)

Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes.
di: Magri, Marta S, et al.
Pubblicazione: (2026)

Mechanistic basis of temperature adaptation in microtubule dynamics across frog species.
di: Troman, Luca, et al.
Pubblicazione: (2025)

Identification of Deoxy- and -Tetrodotoxin Analogues from the Newt Suggests Stepwise Oxidation in Terrestrial Tetrodotoxin Biosynthesis.
di: Horie, Shugo, et al.
Pubblicazione: (2026)

Challenges of Epigenetics in Tissue Culture and Plant Breeding
di: Kr Singh, Mukesh, et al.
Pubblicazione: (2025)

Impact of histone post-translational modification inhibitors on lifespan, reproduction, and stress response in the rotifer Brachionus manjavacas.
di: Luviano Aparicio, Nelia, et al.
Pubblicazione: (2025)

Phylogenetic distribution and structural characteristics of the Lrs14-type proteins
di: De Kock, Veerke, et al.
Pubblicazione: (2026)

Design and implementation of a 6 degrees of freedom controller for the GRACE system
di: William Jesús Retana-Calvo
Pubblicazione: (2020)

Negentropic Thermal Gradients: Experimental Evidence of Entropy Decrease Driven by Active Heat Flux
di: Guzzon, Andre
Pubblicazione: (2026)

Isolation and Structure Elucidation of Uric Acid Lowering Lipopeptides from an sp. Marine Cyanobacterium.
di: Higa, Sein, et al.
Pubblicazione: (2025)

The ancient E-ring in bacterial flagellar motors.
di: Zhu, Siqi, et al.
Pubblicazione: (2026)

Sequence-independent 6mA methyltransferases for epigenetic profiling and editing.
di: Zhang, Jiachen, et al.
Pubblicazione: (2026)

Identification of novel H2A histone variants across diverse clades of algae.
di: Rousselot, Ellyn, et al.
Pubblicazione: (2025)

Structural insight into sodium ion pathway in the bacterial flagellar stator from marine .
di: Nishikino, Tatsuro, et al.
Pubblicazione: (2025)

Computed Tomography Dose Index in Computed Tomography (CT), Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT)
di: Mahajan, Rahul P
Pubblicazione: (2025)

Combined Hierarchical Watershed Segmentation and SVM Classification for Pap Smear Cell Nucleus Extraction
di: Maykel Orozco-Monteagudo
Pubblicazione: (2012)

Etude comparative par epiflorescence et cytometrie en flux des communautés bactériennes des eaux de la retenue du barrage Sidi Salem (Tunisie septentrionale)
di: Ben Romdhane, Samira, et al.
Pubblicazione: (2014)

KDM5C: A dual-edged epigenetic regulator in cancer biology-context-dependent roles and therapeutic implications.
di: Tu, Fei-Yang, et al.
Pubblicazione: (2025)

Effect of Epigenetic Inhibitors on Adipogenesis in Human Periodontal Ligament Stem Cells
di: Julio A. Montero-Del-Toro
Pubblicazione: (2025)

Identification of housekeeping gene for future studies exploring effects of cryopreservation on gene expression in shrimp.
di: Chen, Yen-Po, et al.
Pubblicazione: (2025)

Characterization of two new soft tissue equivalent materials based on Synchrotron X-ray Computed Tomography - Data processing
di: Iori, Gianluca, et al.
Pubblicazione: (2025)

Targeting the female endocannabinoid system (FECS): Phytocannabinoid supplementation and complementary and alternative medicine (CAM) practices for postpartum depression and iron deficiency
di: Persad, Clare Petal
Pubblicazione: (2025)

An acetyl-dependent proofreading mechanism governs synthetic fidelity in Phytophthora sojae chitin synthase.
di: Zhang, Xiaoyue, et al.
Pubblicazione: (2026)

Rubisco packaging and stoichiometric composition of the native β-carboxysome in Synechococcus elongatus PCC7942.
di: Sun, Yaqi, et al.
Pubblicazione: (2024)

Figure 1 from: Huang Y, Zhong Y, Wu T, Huang Y, Tian L (2026) Taxonomy of the ant genus Cardiocondyla Emery, 1869 from China, with the description of a new species of the sima group (Hymenoptera, Formicidae). ZooKeys 1276: 171-212. https://doi.org/10.3897/zookeys.1276.183523
di: Huang, Yi, et al.
Pubblicazione: (2026)

Figure 6 from: Huang Y, Zhong Y, Wu T, Huang Y, Tian L (2026) Taxonomy of the ant genus Cardiocondyla Emery, 1869 from China, with the description of a new species of the sima group (Hymenoptera, Formicidae). ZooKeys 1276: 171-212. https://doi.org/10.3897/zookeys.1276.183523
di: Huang, Yi, et al.
Pubblicazione: (2026)

Figure 18 from: Huang Y, Zhong Y, Wu T, Huang Y, Tian L (2026) Taxonomy of the ant genus Cardiocondyla Emery, 1869 from China, with the description of a new species of the sima group (Hymenoptera, Formicidae). ZooKeys 1276: 171-212. https://doi.org/10.3897/zookeys.1276.183523
di: Huang, Yi, et al.
Pubblicazione: (2026)

if (filemtime($filename) + $maxlifetime < time()) { unlink($filename); $count++; } } return $count; } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ protected function saveSession($sessId, $data): bool { $sessFile = $this->path . '/sess_' . $sessId; if ($handle = fopen($sessFile, 'w')) { $return = false; // Lock the file for exclusive access to avoid issues with multiple // processes writing session simultaneously: if (flock($handle, LOCK_EX)) { $return = fwrite($handle, $data); // Make sure that there's no trailing data by truncating the file to // the correct length: ftruncate($handle, strlen($data)); fflush($handle); flock($handle, LOCK_UN); } fclose($handle); if ($return !== false) { return true; } } // If we got this far, something went wrong with the file output... // It is tempting to throw an exception here, but this code is called // outside of the context of exception handling, so all we can do is // echo a message.

// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

Environment & details:

GET Data empty

POST Data empty

Files empty

Key	Value
language	"it"
VUFIND_SESSION	"50ea4ff255ea2d9235d8dca6dfb44691"
ui	"standard"

Session

Key	Value
__Laminas	array:2 [`"_REQUEST_ACCESS_TIME" => 1790359043.5443 "_VALID" => array:1 [ "Laminas\Session\Validator\Id" => "50ea4ff255ea2d9235d8dca6dfb44691" ]`]
SessionState	Laminas\Stdlib\ArrayObject {#938}
FlashMessenger	Laminas\Stdlib\ArrayObject {#1428}
SessionHelper	Laminas\Stdlib\ArrayObject {#1760}

Server/Request Data

Key	Value
REDIRECT_VUFIND_LOCAL_DIR	"/usr/local/vufind/local"
REDIRECT_HTTPS	"on"
REDIRECT_SSL_TLS_SNI	"info.umar.mx"
REDIRECT_STATUS	"200"
VUFIND_LOCAL_DIR	"/usr/local/vufind/local"
HTTPS	"on"
SSL_TLS_SNI	"info.umar.mx"
HTTP_ACCEPT	"/"
HTTP_USER_AGENT	"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
HTTP_COOKIE	"language=it; VUFIND_SESSION=50ea4ff255ea2d9235d8dca6dfb44691; ui=standard"
HTTP_ACCEPT_ENCODING	"gzip, br, zstd, deflate"
HTTP_HOST	"info.umar.mx"
PATH	"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/snap/bin"
SERVER_SIGNATURE	"<address>Apache/2.4.66 (Ubuntu) Server at info.umar.mx Port 443</address>\n"
SERVER_SOFTWARE	"Apache/2.4.66 (Ubuntu)"
SERVER_NAME	"info.umar.mx"
SERVER_ADDR	"200.23.222.19"
SERVER_PORT	"443"
REMOTE_ADDR	"216.73.216.147"
DOCUMENT_ROOT	"/usr/local/vufind/public"
REQUEST_SCHEME	"https"
CONTEXT_PREFIX	""
CONTEXT_DOCUMENT_ROOT	"/usr/local/vufind/public"
SERVER_ADMIN	"admin@localhost"
SCRIPT_FILENAME	"/usr/local/vufind/public/index.php"
REMOTE_PORT	"58666"
REDIRECT_URL	"/Record/pubmed_41343645/Similar"
GATEWAY_INTERFACE	"CGI/1.1"
SERVER_PROTOCOL	"HTTP/1.1"
REQUEST_METHOD	"GET"
QUERY_STRING	""
REQUEST_URI	"/Record/pubmed_41343645/Similar"
SCRIPT_NAME	"/index.php"
PHP_SELF	"/index.php"
REQUEST_TIME_FLOAT	1790359043.5401
REQUEST_TIME	1790359043

Environment Variables empty

Registered Handlers

0. Whoops\Handler\PrettyPageHandler