Lactone-Facilitated Chemoenzymatic Synthesis of Sulfoglucuronosyl Paragloboside Oligosaccharides Bearing the HNK-1 Epitope.
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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Organic letters
2025
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| _version_ | 1868266114450980865 |
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| author | Gao, Tian Lu, Na Yao, Wenlong Wang, Xichao Liu, Yangyang Sun, Linlin Cai, Meichao Song, Yu Rong, Rong Cao, Hongzhi |
| author_facet | Gao, Tian Lu, Na Yao, Wenlong Wang, Xichao Liu, Yangyang Sun, Linlin Cai, Meichao Song, Yu Rong, Rong Cao, Hongzhi Gao, Tian Lu, Na Yao, Wenlong Wang, Xichao Liu, Yangyang Sun, Linlin Cai, Meichao Song, Yu Rong, Rong Cao, Hongzhi |
| collection | PubMed - marine biology |
| contents | Lactone-Facilitated Chemoenzymatic Synthesis of Sulfoglucuronosyl Paragloboside Oligosaccharides Bearing the HNK-1 Epitope. Gao, Tian Lu, Na Yao, Wenlong Wang, Xichao Liu, Yangyang Sun, Linlin Cai, Meichao Song, Yu Rong, Rong Cao, Hongzhi Oligosaccharides Lactones Molecular Structure Epitopes Herein, we describe a lactone-facilitated chemoenzymatic strategy for the synthesis of sulfoglucuronosyl paragloboside pentasaccharide, sulfoglucuronosyl lactosaminylparagloboside heptasaccharide, and their nonsulfated derivatives. The approach involves the efficient enzymatic modular assembly (EMA) of the nonsulfated paragloboside backbones, followed by highly regioselective chemical manipulation steps that introduce a sulfate group at the C3 position of glucuronic acid through the formation of a C6,3-lactone intermediate. |
| format | Artículo científico |
| id | pubmed_41355321 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Organic letters |
| record_format | pubmed |
| spellingShingle | Lactone-Facilitated Chemoenzymatic Synthesis of Sulfoglucuronosyl Paragloboside Oligosaccharides Bearing the HNK-1 Epitope. Gao, Tian Lu, Na Yao, Wenlong Wang, Xichao Liu, Yangyang Sun, Linlin Cai, Meichao Song, Yu Rong, Rong Cao, Hongzhi Oligosaccharides Lactones Molecular Structure Epitopes Lactone-Facilitated Chemoenzymatic Synthesis of Sulfoglucuronosyl Paragloboside Oligosaccharides Bearing the HNK-1 Epitope. Gao, Tian Lu, Na Yao, Wenlong Wang, Xichao Liu, Yangyang Sun, Linlin Cai, Meichao Song, Yu Rong, Rong Cao, Hongzhi Oligosaccharides Lactones Molecular Structure Epitopes Herein, we describe a lactone-facilitated chemoenzymatic strategy for the synthesis of sulfoglucuronosyl paragloboside pentasaccharide, sulfoglucuronosyl lactosaminylparagloboside heptasaccharide, and their nonsulfated derivatives. The approach involves the efficient enzymatic modular assembly (EMA) of the nonsulfated paragloboside backbones, followed by highly regioselective chemical manipulation steps that introduce a sulfate group at the C3 position of glucuronic acid through the formation of a C6,3-lactone intermediate. |
| title | Lactone-Facilitated Chemoenzymatic Synthesis of Sulfoglucuronosyl Paragloboside Oligosaccharides Bearing the HNK-1 Epitope. |
| topic | Oligosaccharides Lactones Molecular Structure Epitopes |
| url | https://pubmed.ncbi.nlm.nih.gov/41355321/ |