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| Autori principali: | , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Journal of natural products
2025
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/41355802/ |
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| _version_ | 1868266114450980864 |
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| author | Liu, Yi-Yi Chen, Hai-Xin Chen, Guang-Ying Nong, Xu-Hua Han, Zhuang |
| author_facet | Liu, Yi-Yi Chen, Hai-Xin Chen, Guang-Ying Nong, Xu-Hua Han, Zhuang Liu, Yi-Yi Chen, Hai-Xin Chen, Guang-Ying Nong, Xu-Hua Han, Zhuang |
| collection | PubMed - marine biology |
| contents | Candindoles A and B, Heterozygous Terphenyl-Indole Alkaloids with Antifungal and Cytotoxic Activities from the Marine-Derived Fungus HNNU0546. Liu, Yi-Yi Chen, Hai-Xin Chen, Guang-Ying Nong, Xu-Hua Han, Zhuang Aspergillus Indole Alkaloids Humans Antifungal Agents Molecular Structure Antineoplastic Agents Drug Screening Assays, Antitumor Microbial Sensitivity Tests Alternaria Cell Line, Tumor Marine Biology Three previously undescribed indole alkaloids, candindoles A-C (-), along with five known analogues (-), were isolated from the marine-derived fungus HNNU0546. Structurally, and represent the first terphenyl-indole piperazine alkaloid hybrids featuring unprecedented backbones. Their structures including absolute configurations were elucidated by extensive spectroscopic methods, DP4+ probability analysis, and electronic circular dichroism (ECD) calculations. A plausible biosynthetic pathway for is proposed. Compound exhibited moderate growth-inhibitory activity against the plant pathogenic fungus of sp. with an EC value of 19.21 ± 0.26 μM, while compounds and showed significant cytotoxicity toward human rhabdomyosarcoma cells A673 with IC values of 7.72 and 8.89 μM, respectively, comparable to the positive control cisplatin. |
| format | Artículo científico |
| id | pubmed_41355802 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of natural products |
| record_format | pubmed |
| spellingShingle | Candindoles A and B, Heterozygous Terphenyl-Indole Alkaloids with Antifungal and Cytotoxic Activities from the Marine-Derived Fungus HNNU0546. Liu, Yi-Yi Chen, Hai-Xin Chen, Guang-Ying Nong, Xu-Hua Han, Zhuang Aspergillus Indole Alkaloids Humans Antifungal Agents Molecular Structure Antineoplastic Agents Drug Screening Assays, Antitumor Microbial Sensitivity Tests Alternaria Cell Line, Tumor Marine Biology Candindoles A and B, Heterozygous Terphenyl-Indole Alkaloids with Antifungal and Cytotoxic Activities from the Marine-Derived Fungus HNNU0546. Liu, Yi-Yi Chen, Hai-Xin Chen, Guang-Ying Nong, Xu-Hua Han, Zhuang Aspergillus Indole Alkaloids Humans Antifungal Agents Molecular Structure Antineoplastic Agents Drug Screening Assays, Antitumor Microbial Sensitivity Tests Alternaria Cell Line, Tumor Marine Biology Three previously undescribed indole alkaloids, candindoles A-C (-), along with five known analogues (-), were isolated from the marine-derived fungus HNNU0546. Structurally, and represent the first terphenyl-indole piperazine alkaloid hybrids featuring unprecedented backbones. Their structures including absolute configurations were elucidated by extensive spectroscopic methods, DP4+ probability analysis, and electronic circular dichroism (ECD) calculations. A plausible biosynthetic pathway for is proposed. Compound exhibited moderate growth-inhibitory activity against the plant pathogenic fungus of sp. with an EC value of 19.21 ± 0.26 μM, while compounds and showed significant cytotoxicity toward human rhabdomyosarcoma cells A673 with IC values of 7.72 and 8.89 μM, respectively, comparable to the positive control cisplatin. |
| title | Candindoles A and B, Heterozygous Terphenyl-Indole Alkaloids with Antifungal and Cytotoxic Activities from the Marine-Derived Fungus HNNU0546. |
| topic | Aspergillus Indole Alkaloids Humans Antifungal Agents Molecular Structure Antineoplastic Agents Drug Screening Assays, Antitumor Microbial Sensitivity Tests Alternaria Cell Line, Tumor Marine Biology |
| url | https://pubmed.ncbi.nlm.nih.gov/41355802/ |