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| Autores principales: | , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
International journal of molecular sciences
2025
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/41373438/ |
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| _version_ | 1868266114432106496 |
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| author | Wang, Yi-Chen Tai, Shun-Ban Yang, Jenq-Lin Liu, Pei-Feng Sung, Ping-Jyun Su, Jui-Hsin Chen, Chun-Lin |
| author_facet | Wang, Yi-Chen Tai, Shun-Ban Yang, Jenq-Lin Liu, Pei-Feng Sung, Ping-Jyun Su, Jui-Hsin Chen, Chun-Lin Wang, Yi-Chen Tai, Shun-Ban Yang, Jenq-Lin Liu, Pei-Feng Sung, Ping-Jyun Su, Jui-Hsin Chen, Chun-Lin |
| collection | PubMed - marine biology |
| contents | Analysis of Cembrane-Type Diterpenoids from Cultured Soft Coral for Inhibition of TGF-β-Induced IL-6 Secretion in Inflammation-Associated Cancer. Wang, Yi-Chen Tai, Shun-Ban Yang, Jenq-Lin Liu, Pei-Feng Sung, Ping-Jyun Su, Jui-Hsin Chen, Chun-Lin Interleukin-6 Animals Anthozoa Diterpenes Transforming Growth Factor beta Inflammation Humans Anti-Inflammatory Agents Structure-Activity Relationship Neoplasms Cell Line, Tumor Mice Signal Transduction Cembrane-type diterpenoids (cembranoids), natural compounds derived from soft coral , exhibit diverse biological activities including anti-inflammatory, anti-cancer, and anti-viral effects. Our previous research demonstrated that Sinulariolide, a member of this group, effectively inhibits TGF-β-induced IL-6 secretion, thereby suppressing inflammation-associated cancer development. Building on these findings, the present study employs a structure-activity relationship (SAR) approach to compare the anti-inflammatory properties of various cembranoids extracted from cultured soft coral -a sustainable and environmentally friendly source that offers a consistent supply for research and therapeutic development. By isolating multiple cembrane-type analogs and analyzing their structural differences, we identified key chemical features that enhance their ability to interfere with TGF-β signaling and subsequent IL-6 production. The SAR analysis revealed distinct variations in anti-inflammatory efficacy among the tested compounds, pinpointing structural motifs crucial for inhibiting TGF-β-induced IL-6 secretion. These insights deepen our understanding of the molecular basis behind the anti-inflammatory action of cembranoids and guide the optimization of these compounds for potential therapeutic use. |
| format | Artículo científico |
| id | pubmed_41373438 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | International journal of molecular sciences |
| record_format | pubmed |
| spellingShingle | Analysis of Cembrane-Type Diterpenoids from Cultured Soft Coral for Inhibition of TGF-β-Induced IL-6 Secretion in Inflammation-Associated Cancer. Wang, Yi-Chen Tai, Shun-Ban Yang, Jenq-Lin Liu, Pei-Feng Sung, Ping-Jyun Su, Jui-Hsin Chen, Chun-Lin Interleukin-6 Animals Anthozoa Diterpenes Transforming Growth Factor beta Inflammation Humans Anti-Inflammatory Agents Structure-Activity Relationship Neoplasms Cell Line, Tumor Mice Signal Transduction Analysis of Cembrane-Type Diterpenoids from Cultured Soft Coral for Inhibition of TGF-β-Induced IL-6 Secretion in Inflammation-Associated Cancer. Wang, Yi-Chen Tai, Shun-Ban Yang, Jenq-Lin Liu, Pei-Feng Sung, Ping-Jyun Su, Jui-Hsin Chen, Chun-Lin Interleukin-6 Animals Anthozoa Diterpenes Transforming Growth Factor beta Inflammation Humans Anti-Inflammatory Agents Structure-Activity Relationship Neoplasms Cell Line, Tumor Mice Signal Transduction Cembrane-type diterpenoids (cembranoids), natural compounds derived from soft coral , exhibit diverse biological activities including anti-inflammatory, anti-cancer, and anti-viral effects. Our previous research demonstrated that Sinulariolide, a member of this group, effectively inhibits TGF-β-induced IL-6 secretion, thereby suppressing inflammation-associated cancer development. Building on these findings, the present study employs a structure-activity relationship (SAR) approach to compare the anti-inflammatory properties of various cembranoids extracted from cultured soft coral -a sustainable and environmentally friendly source that offers a consistent supply for research and therapeutic development. By isolating multiple cembrane-type analogs and analyzing their structural differences, we identified key chemical features that enhance their ability to interfere with TGF-β signaling and subsequent IL-6 production. The SAR analysis revealed distinct variations in anti-inflammatory efficacy among the tested compounds, pinpointing structural motifs crucial for inhibiting TGF-β-induced IL-6 secretion. These insights deepen our understanding of the molecular basis behind the anti-inflammatory action of cembranoids and guide the optimization of these compounds for potential therapeutic use. |
| title | Analysis of Cembrane-Type Diterpenoids from Cultured Soft Coral for Inhibition of TGF-β-Induced IL-6 Secretion in Inflammation-Associated Cancer. |
| topic | Interleukin-6 Animals Anthozoa Diterpenes Transforming Growth Factor beta Inflammation Humans Anti-Inflammatory Agents Structure-Activity Relationship Neoplasms Cell Line, Tumor Mice Signal Transduction |
| url | https://pubmed.ncbi.nlm.nih.gov/41373438/ |