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| Autores principales: | , , , , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Journal of natural products
2025
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/41388994/ |
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| _version_ | 1868266111393333249 |
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| author | Wang, Biao Yang, Xiao Song, Rongfa Yao, Michi Liu, Yuanqian Guo, Zhikai He, Bo Li, Yu Ye, Yonghao Yan, Wei |
| author_facet | Wang, Biao Yang, Xiao Song, Rongfa Yao, Michi Liu, Yuanqian Guo, Zhikai He, Bo Li, Yu Ye, Yonghao Yan, Wei Wang, Biao Yang, Xiao Song, Rongfa Yao, Michi Liu, Yuanqian Guo, Zhikai He, Bo Li, Yu Ye, Yonghao Yan, Wei |
| collection | PubMed - marine biology |
| contents | Versilulins A-D, Spiroketals, and Diphenyl Ether Derivatives from Marine-Derived 347 with Antibacterial Activity. Wang, Biao Yang, Xiao Song, Rongfa Yao, Michi Liu, Yuanqian Guo, Zhikai He, Bo Li, Yu Ye, Yonghao Yan, Wei Anti-Bacterial Agents Aspergillus Spiro Compounds Phenyl Ethers Molecular Structure Microbial Sensitivity Tests Furans Staphylococcus aureus Four unreported compounds, including two pairs of spiroketal racemates, (±)-versilulin A ( and ) and (±)-versilulin B ( and ), and two diphenyl ether derivatives, versilulins C and D ( and ), together with four known compounds (-), were isolated from the endophytic fungus 347. The assignment of their structures was accomplished by spectroscopic analysis, including HRESIMS, NMR, chiral analysis, ECD calculation, and X-ray diffraction. Among them, compounds and possess an unprecedented 6/5/6/6 tetracyclic polyketide with a unique 1,4-dioxospiro[4.5]decan-8-one core skeleton. Compound was characterized by an unusual 6/6/6/6/6/6 hexacyclic ring system featuring a rare 9-oxospiro[5.5]undecan-3-one. Compound contains a novel 6/8/6/6/6/6 hexacyclic fused ring system. Biological assays revealed that compounds and displayed modest antibacterial activity against with an equal MIC value of 32 μg/mL. |
| format | Artículo científico |
| id | pubmed_41388994 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of natural products |
| record_format | pubmed |
| spellingShingle | Versilulins A-D, Spiroketals, and Diphenyl Ether Derivatives from Marine-Derived 347 with Antibacterial Activity. Wang, Biao Yang, Xiao Song, Rongfa Yao, Michi Liu, Yuanqian Guo, Zhikai He, Bo Li, Yu Ye, Yonghao Yan, Wei Anti-Bacterial Agents Aspergillus Spiro Compounds Phenyl Ethers Molecular Structure Microbial Sensitivity Tests Furans Staphylococcus aureus Versilulins A-D, Spiroketals, and Diphenyl Ether Derivatives from Marine-Derived 347 with Antibacterial Activity. Wang, Biao Yang, Xiao Song, Rongfa Yao, Michi Liu, Yuanqian Guo, Zhikai He, Bo Li, Yu Ye, Yonghao Yan, Wei Anti-Bacterial Agents Aspergillus Spiro Compounds Phenyl Ethers Molecular Structure Microbial Sensitivity Tests Furans Staphylococcus aureus Four unreported compounds, including two pairs of spiroketal racemates, (±)-versilulin A ( and ) and (±)-versilulin B ( and ), and two diphenyl ether derivatives, versilulins C and D ( and ), together with four known compounds (-), were isolated from the endophytic fungus 347. The assignment of their structures was accomplished by spectroscopic analysis, including HRESIMS, NMR, chiral analysis, ECD calculation, and X-ray diffraction. Among them, compounds and possess an unprecedented 6/5/6/6 tetracyclic polyketide with a unique 1,4-dioxospiro[4.5]decan-8-one core skeleton. Compound was characterized by an unusual 6/6/6/6/6/6 hexacyclic ring system featuring a rare 9-oxospiro[5.5]undecan-3-one. Compound contains a novel 6/8/6/6/6/6 hexacyclic fused ring system. Biological assays revealed that compounds and displayed modest antibacterial activity against with an equal MIC value of 32 μg/mL. |
| title | Versilulins A-D, Spiroketals, and Diphenyl Ether Derivatives from Marine-Derived 347 with Antibacterial Activity. |
| topic | Anti-Bacterial Agents Aspergillus Spiro Compounds Phenyl Ethers Molecular Structure Microbial Sensitivity Tests Furans Staphylococcus aureus |
| url | https://pubmed.ncbi.nlm.nih.gov/41388994/ |