Hazard identification and characterization of leachable chemicals from plastic products - a new PARC project.
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| Format: | Artículo científico |
| Language: | en |
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Frontiers in toxicology
2025
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| author | Dirven, Hubert Bogusz, Aleksandra Bouwmeester, Hans Busch, Mathias Duflos, Guillaume Eriksen, Gunnar S Fardilha, Margarida Flores-Gomez, Daniela Franko, Nina Gaté, Laurent Guichard, Yves Silva, Maria João Kamstra, Jorke H Kasiotis, Konstantinos M Kim, Sunmi Kim, Young Jun Kim, Youngsam van der Koogh, Elise Loureiro, Susana Louro, Henriqueta Machera, Kyriaki Pieters, Raymond H H Spyropoulou, Anastasia Tzanetou, Evangelia N Malheiro, Catarina Ravnjak, Tim Repetto, Guillermo Rivière, Gilles Ryu, Chang Seon Papadopoulou, Evgenia Anna Aliferis, Konstantinos A Solhaug, Anita Dolenc, Marija Sollner Štampar, Martina Tavares, Ana M Tollefsen, Knut Erik Ventura, Célia Walkowiak, Radoslaw Zobl, Walter Žegura, Bojana Snapkow, Igor Herzke, Dorte |
| author_facet | Dirven, Hubert Bogusz, Aleksandra Bouwmeester, Hans Busch, Mathias Duflos, Guillaume Eriksen, Gunnar S Fardilha, Margarida Flores-Gomez, Daniela Franko, Nina Gaté, Laurent Guichard, Yves Silva, Maria João Kamstra, Jorke H Kasiotis, Konstantinos M Kim, Sunmi Kim, Young Jun Kim, Youngsam van der Koogh, Elise Loureiro, Susana Louro, Henriqueta Machera, Kyriaki Pieters, Raymond H H Spyropoulou, Anastasia Tzanetou, Evangelia N Malheiro, Catarina Ravnjak, Tim Repetto, Guillermo Rivière, Gilles Ryu, Chang Seon Papadopoulou, Evgenia Anna Aliferis, Konstantinos A Solhaug, Anita Dolenc, Marija Sollner Štampar, Martina Tavares, Ana M Tollefsen, Knut Erik Ventura, Célia Walkowiak, Radoslaw Zobl, Walter Žegura, Bojana Snapkow, Igor Herzke, Dorte Dirven, Hubert Bogusz, Aleksandra Bouwmeester, Hans Busch, Mathias Duflos, Guillaume Eriksen, Gunnar S Fardilha, Margarida Flores-Gomez, Daniela Franko, Nina Gaté, Laurent Guichard, Yves Silva, Maria João Kamstra, Jorke H Kasiotis, Konstantinos M Kim, Sunmi Kim, Young Jun Kim, Youngsam van der Koogh, Elise Loureiro, Susana Louro, Henriqueta Machera, Kyriaki Pieters, Raymond H H Spyropoulou, Anastasia Tzanetou, Evangelia N Malheiro, Catarina Ravnjak, Tim Repetto, Guillermo Rivière, Gilles Ryu, Chang Seon Papadopoulou, Evgenia Anna Aliferis, Konstantinos A Solhaug, Anita Dolenc, Marija Sollner Štampar, Martina Tavares, Ana M Tollefsen, Knut Erik Ventura, Célia Walkowiak, Radoslaw Zobl, Walter Žegura, Bojana Snapkow, Igor Herzke, Dorte |
| collection | PubMed - marine biology |
| contents | Hazard identification and characterization of leachable chemicals from plastic products - a new PARC project. Dirven, Hubert Bogusz, Aleksandra Bouwmeester, Hans Busch, Mathias Duflos, Guillaume Eriksen, Gunnar S Fardilha, Margarida Flores-Gomez, Daniela Franko, Nina Gaté, Laurent Guichard, Yves Silva, Maria João Kamstra, Jorke H Kasiotis, Konstantinos M Kim, Sunmi Kim, Young Jun Kim, Youngsam van der Koogh, Elise Loureiro, Susana Louro, Henriqueta Machera, Kyriaki Pieters, Raymond H H Spyropoulou, Anastasia Tzanetou, Evangelia N Malheiro, Catarina Ravnjak, Tim Repetto, Guillermo Rivière, Gilles Ryu, Chang Seon Papadopoulou, Evgenia Anna Aliferis, Konstantinos A Solhaug, Anita Dolenc, Marija Sollner Štampar, Martina Tavares, Ana M Tollefsen, Knut Erik Ventura, Célia Walkowiak, Radoslaw Zobl, Walter Žegura, Bojana Snapkow, Igor Herzke, Dorte A recent study has suggested that plastics may contain more than 16,000 chemicals, including additives, processing aids, starting substances, intermediates and Non-Intentionally Added Substances. Plastic chemicals are released throughout the plastic life cycle, from production, use, disposal and recycling. Most of these chemicals have not been studied for potential hazardous properties for humans and in the environment. To refine the risk assessment of these leachable chemicals, additional hazard data are needed. The PlasticLeach project within the EU co-funded Partnership for the Assessment of Risks from Chemicals (PARC) aims to address this data gap by screening several plastic products in daily use. Leachates will be prepared from a number of these plastic items, and these chemical mixtures will be further tested using several test guideline compliant assays and New Approach Methodologies covering both human health and environmental endpoints. The most toxic leachates will be characterized using a non-targeted analysis pipeline to identify chemicals in the leachate. When single chemicals of concern are identified, these will be further tested to determine hazardous properties and identify the respective potency factors to better understand their specific hazard profiles. A tiered approach for hazard testing will be followed. The experimental work will be complemented by toxicological profiling, using publicly available toxicity databases and tools, including Artificial Intelligence tools that cover both human and environmental endpoints. A comprehensive array of endpoints, including cytotoxicity, endocrine disruption, genotoxicity, immunotoxicity, reproductive toxicity and effects related to ecotoxicity will be evaluated. In this paper, we outline the plastic products to be tested and the battery of assays that will be used to identify hazards relevant to both human health and the environment. Data generated from , , and approaches will be reported using standardized formats, stored within a centralized repository, and harmonized to adhere to the FAIR data principles (Findable, Accessible, Interoperable, and Reusable). This integrated strategy will not only advance our understanding of the risks associated with plastic-derived chemicals but will also provide critical support for regulatory decision-making and facilitate the development of safer, and more ecofriendly plastic materials in the future. |
| format | Artículo científico |
| id | pubmed_41393343 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Frontiers in toxicology |
| record_format | pubmed |
| spellingShingle | Hazard identification and characterization of leachable chemicals from plastic products - a new PARC project. Dirven, Hubert Bogusz, Aleksandra Bouwmeester, Hans Busch, Mathias Duflos, Guillaume Eriksen, Gunnar S Fardilha, Margarida Flores-Gomez, Daniela Franko, Nina Gaté, Laurent Guichard, Yves Silva, Maria João Kamstra, Jorke H Kasiotis, Konstantinos M Kim, Sunmi Kim, Young Jun Kim, Youngsam van der Koogh, Elise Loureiro, Susana Louro, Henriqueta Machera, Kyriaki Pieters, Raymond H H Spyropoulou, Anastasia Tzanetou, Evangelia N Malheiro, Catarina Ravnjak, Tim Repetto, Guillermo Rivière, Gilles Ryu, Chang Seon Papadopoulou, Evgenia Anna Aliferis, Konstantinos A Solhaug, Anita Dolenc, Marija Sollner Štampar, Martina Tavares, Ana M Tollefsen, Knut Erik Ventura, Célia Walkowiak, Radoslaw Zobl, Walter Žegura, Bojana Snapkow, Igor Herzke, Dorte Hazard identification and characterization of leachable chemicals from plastic products - a new PARC project. Dirven, Hubert Bogusz, Aleksandra Bouwmeester, Hans Busch, Mathias Duflos, Guillaume Eriksen, Gunnar S Fardilha, Margarida Flores-Gomez, Daniela Franko, Nina Gaté, Laurent Guichard, Yves Silva, Maria João Kamstra, Jorke H Kasiotis, Konstantinos M Kim, Sunmi Kim, Young Jun Kim, Youngsam van der Koogh, Elise Loureiro, Susana Louro, Henriqueta Machera, Kyriaki Pieters, Raymond H H Spyropoulou, Anastasia Tzanetou, Evangelia N Malheiro, Catarina Ravnjak, Tim Repetto, Guillermo Rivière, Gilles Ryu, Chang Seon Papadopoulou, Evgenia Anna Aliferis, Konstantinos A Solhaug, Anita Dolenc, Marija Sollner Štampar, Martina Tavares, Ana M Tollefsen, Knut Erik Ventura, Célia Walkowiak, Radoslaw Zobl, Walter Žegura, Bojana Snapkow, Igor Herzke, Dorte A recent study has suggested that plastics may contain more than 16,000 chemicals, including additives, processing aids, starting substances, intermediates and Non-Intentionally Added Substances. Plastic chemicals are released throughout the plastic life cycle, from production, use, disposal and recycling. Most of these chemicals have not been studied for potential hazardous properties for humans and in the environment. To refine the risk assessment of these leachable chemicals, additional hazard data are needed. The PlasticLeach project within the EU co-funded Partnership for the Assessment of Risks from Chemicals (PARC) aims to address this data gap by screening several plastic products in daily use. Leachates will be prepared from a number of these plastic items, and these chemical mixtures will be further tested using several test guideline compliant assays and New Approach Methodologies covering both human health and environmental endpoints. The most toxic leachates will be characterized using a non-targeted analysis pipeline to identify chemicals in the leachate. When single chemicals of concern are identified, these will be further tested to determine hazardous properties and identify the respective potency factors to better understand their specific hazard profiles. A tiered approach for hazard testing will be followed. The experimental work will be complemented by toxicological profiling, using publicly available toxicity databases and tools, including Artificial Intelligence tools that cover both human and environmental endpoints. A comprehensive array of endpoints, including cytotoxicity, endocrine disruption, genotoxicity, immunotoxicity, reproductive toxicity and effects related to ecotoxicity will be evaluated. In this paper, we outline the plastic products to be tested and the battery of assays that will be used to identify hazards relevant to both human health and the environment. Data generated from , , and approaches will be reported using standardized formats, stored within a centralized repository, and harmonized to adhere to the FAIR data principles (Findable, Accessible, Interoperable, and Reusable). This integrated strategy will not only advance our understanding of the risks associated with plastic-derived chemicals but will also provide critical support for regulatory decision-making and facilitate the development of safer, and more ecofriendly plastic materials in the future. |
| title | Hazard identification and characterization of leachable chemicals from plastic products - a new PARC project. |
| url | https://pubmed.ncbi.nlm.nih.gov/41393343/ |