Oxalicpyridones A-D, 2-pyridone alkaloids from a marine-derived fungus Penicillium oxalicum suppressing proliferation and metastasis against small cell lung cancer.
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| Format: | Artículo científico |
| Sprache: | en |
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Phytochemistry
2026
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| author | Chen, Xiangliu Wong, Ini Cong, Mengjing Chen, Weihao Jin, Meng Wang, Hong Chen, Fangfang Zhang, Qingwen Liu, Kechun Liu, Yonghong Wang, Rongchun Wang, Junjian Wang, Junfeng |
| author_facet | Chen, Xiangliu Wong, Ini Cong, Mengjing Chen, Weihao Jin, Meng Wang, Hong Chen, Fangfang Zhang, Qingwen Liu, Kechun Liu, Yonghong Wang, Rongchun Wang, Junjian Wang, Junfeng Chen, Xiangliu Wong, Ini Cong, Mengjing Chen, Weihao Jin, Meng Wang, Hong Chen, Fangfang Zhang, Qingwen Liu, Kechun Liu, Yonghong Wang, Rongchun Wang, Junjian Wang, Junfeng |
| collection | PubMed - marine biology |
| contents | Oxalicpyridones A-D, 2-pyridone alkaloids from a marine-derived fungus Penicillium oxalicum suppressing proliferation and metastasis against small cell lung cancer. Chen, Xiangliu Wong, Ini Cong, Mengjing Chen, Weihao Jin, Meng Wang, Hong Chen, Fangfang Zhang, Qingwen Liu, Kechun Liu, Yonghong Wang, Rongchun Wang, Junjian Wang, Junfeng Penicillium Humans Pyridones Animals Cell Proliferation Zebrafish Alkaloids Antineoplastic Agents Drug Screening Assays, Antitumor Lung Neoplasms Molecular Structure Small Cell Lung Carcinoma Apoptosis Structure-Activity Relationship Cell Line, Tumor Dose-Response Relationship, Drug Molecular Conformation To explore bioactive specialized metabolites from marine-derived fungi, four previously undescribed 2-pyridone alkaloids, oxalicpyridones A-D (1-4), two unreported tetramic acids, tolypocladenols G and H (5 and 6), together with five known 2-pyridone derivatives (7-11), were isolated from the marine-derived fungus Penicillium oxalicum SCSIO 41320. Their structures, including absolute configurations, were elucidated by extensive nuclear magnetic resonance (NMR) spectroscopic analysis, X-ray single-crystal diffraction, and calculations of electronic circular dichroism (ECD), C NMR, and optical rotation (OR). Additionally, oxalicpyridones A-C (1-3) inhibited the viability of several small-cell lung cancer (SCLC) cell lines in a dose-dependent manner. Among them, oxalicpyridone A (1) not only inhibited proliferation, induced apoptosis, and suppressed metastasis of SCLC cells in vitro, but also significantly inhibited the growth of SCLC cell-derived xenograft tumors in zebrafish in vivo. Collectively, these findings enrich the chemical diversity of marine-derived 2-pyridone alkaloids and provide potential lead compounds for anticancer drug discovery. |
| format | Artículo científico |
| id | pubmed_41397549 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Phytochemistry |
| record_format | pubmed |
| spellingShingle | Oxalicpyridones A-D, 2-pyridone alkaloids from a marine-derived fungus Penicillium oxalicum suppressing proliferation and metastasis against small cell lung cancer. Chen, Xiangliu Wong, Ini Cong, Mengjing Chen, Weihao Jin, Meng Wang, Hong Chen, Fangfang Zhang, Qingwen Liu, Kechun Liu, Yonghong Wang, Rongchun Wang, Junjian Wang, Junfeng Penicillium Humans Pyridones Animals Cell Proliferation Zebrafish Alkaloids Antineoplastic Agents Drug Screening Assays, Antitumor Lung Neoplasms Molecular Structure Small Cell Lung Carcinoma Apoptosis Structure-Activity Relationship Cell Line, Tumor Dose-Response Relationship, Drug Molecular Conformation Oxalicpyridones A-D, 2-pyridone alkaloids from a marine-derived fungus Penicillium oxalicum suppressing proliferation and metastasis against small cell lung cancer. Chen, Xiangliu Wong, Ini Cong, Mengjing Chen, Weihao Jin, Meng Wang, Hong Chen, Fangfang Zhang, Qingwen Liu, Kechun Liu, Yonghong Wang, Rongchun Wang, Junjian Wang, Junfeng Penicillium Humans Pyridones Animals Cell Proliferation Zebrafish Alkaloids Antineoplastic Agents Drug Screening Assays, Antitumor Lung Neoplasms Molecular Structure Small Cell Lung Carcinoma Apoptosis Structure-Activity Relationship Cell Line, Tumor Dose-Response Relationship, Drug Molecular Conformation To explore bioactive specialized metabolites from marine-derived fungi, four previously undescribed 2-pyridone alkaloids, oxalicpyridones A-D (1-4), two unreported tetramic acids, tolypocladenols G and H (5 and 6), together with five known 2-pyridone derivatives (7-11), were isolated from the marine-derived fungus Penicillium oxalicum SCSIO 41320. Their structures, including absolute configurations, were elucidated by extensive nuclear magnetic resonance (NMR) spectroscopic analysis, X-ray single-crystal diffraction, and calculations of electronic circular dichroism (ECD), C NMR, and optical rotation (OR). Additionally, oxalicpyridones A-C (1-3) inhibited the viability of several small-cell lung cancer (SCLC) cell lines in a dose-dependent manner. Among them, oxalicpyridone A (1) not only inhibited proliferation, induced apoptosis, and suppressed metastasis of SCLC cells in vitro, but also significantly inhibited the growth of SCLC cell-derived xenograft tumors in zebrafish in vivo. Collectively, these findings enrich the chemical diversity of marine-derived 2-pyridone alkaloids and provide potential lead compounds for anticancer drug discovery. |
| title | Oxalicpyridones A-D, 2-pyridone alkaloids from a marine-derived fungus Penicillium oxalicum suppressing proliferation and metastasis against small cell lung cancer. |
| topic | Penicillium Humans Pyridones Animals Cell Proliferation Zebrafish Alkaloids Antineoplastic Agents Drug Screening Assays, Antitumor Lung Neoplasms Molecular Structure Small Cell Lung Carcinoma Apoptosis Structure-Activity Relationship Cell Line, Tumor Dose-Response Relationship, Drug Molecular Conformation |
| url | https://pubmed.ncbi.nlm.nih.gov/41397549/ |