Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of virology
2026
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41400355/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266111380750337 |
|---|---|
| author | Lu, Kaiyu Zhang, Jia Zhu, Jinghua Zhao, Yongzhen Chen, Xiuli Zhang, Yueling Yao, Defu |
| author_facet | Lu, Kaiyu Zhang, Jia Zhu, Jinghua Zhao, Yongzhen Chen, Xiuli Zhang, Yueling Yao, Defu Lu, Kaiyu Zhang, Jia Zhu, Jinghua Zhao, Yongzhen Chen, Xiuli Zhang, Yueling Yao, Defu |
| collection | PubMed - marine biology |
| contents | Hijacking of host Src-PI3K-Akt signaling by WSSV IE1 protein suppresses apoptotic and autophagic defenses to facilitate viral proliferation. Lu, Kaiyu Zhang, Jia Zhu, Jinghua Zhao, Yongzhen Chen, Xiuli Zhang, Yueling Yao, Defu Animals Signal Transduction Proto-Oncogene Proteins c-akt Penaeidae Apoptosis White spot syndrome virus 1 Autophagy Phosphatidylinositol 3-Kinases Host-Pathogen Interactions Virus Replication Immediate-Early Proteins src-Family Kinases The phosphoinositide 3-kinase (PI3K)-Akt pathway is a key signaling cascade regulating diverse cellular processes, including proliferation, survival, autophagy, translation, and metabolism. White spot syndrome virus (WSSV), a major pathogen devastating global crustacean aquaculture, has been demonstrated to exploit the PI3K-Akt pathway to facilitate its proliferation. However, the precise mechanism underlying this viral modulation remained unclear. In this study, we demonstrate that WSSV infection induces activation of the PI3K-Akt pathway during the early infection stage in . Mechanistically, we reveal that the WSSV immediate-early protein IE1 interacts with and activates host Src64B kinase via its YFTS tyrosine motif. This specific interaction promotes recruitment of the PI3K regulatory subunit alpha (PI3Kp85α), thereby triggering the downstream PI3K-Akt signaling. By activating this pathway, WSSV establishes a favorable environment for its proliferation by suppressing host apoptotic and autophagic defenses. Our findings unveil a previously unknown mechanism of WSSV immune evasion through Src-PI3K-Akt signaling hijacking and identify components of this signaling hub as potential therapeutic targets for anti-WSSV strategies. Viruses usually hijack host signaling pathways to enhance infectivity and evade immune defenses. Understanding these interactions is critical for elucidating viral pathogenesis and developing effective antiviral strategies. Here, we demonstrate that the WSSV immediate-early protein IE1 binds to and activates host Src64B kinase, which in turn recruits PI3Kp85α and activates the PI3K-Akt signaling cascade. Activation of this pathway suppresses apoptosis and autophagy, thereby facilitating viral proliferation. These findings advance our understanding of WSSV pathogenesis and identify the Src-PI3K-Akt signaling as a promising therapeutic target for anti-WSSV intervention. |
| format | Artículo científico |
| id | pubmed_41400355 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Journal of virology |
| record_format | pubmed |
| spellingShingle | Hijacking of host Src-PI3K-Akt signaling by WSSV IE1 protein suppresses apoptotic and autophagic defenses to facilitate viral proliferation. Lu, Kaiyu Zhang, Jia Zhu, Jinghua Zhao, Yongzhen Chen, Xiuli Zhang, Yueling Yao, Defu Animals Signal Transduction Proto-Oncogene Proteins c-akt Penaeidae Apoptosis White spot syndrome virus 1 Autophagy Phosphatidylinositol 3-Kinases Host-Pathogen Interactions Virus Replication Immediate-Early Proteins src-Family Kinases Hijacking of host Src-PI3K-Akt signaling by WSSV IE1 protein suppresses apoptotic and autophagic defenses to facilitate viral proliferation. Lu, Kaiyu Zhang, Jia Zhu, Jinghua Zhao, Yongzhen Chen, Xiuli Zhang, Yueling Yao, Defu Animals Signal Transduction Proto-Oncogene Proteins c-akt Penaeidae Apoptosis White spot syndrome virus 1 Autophagy Phosphatidylinositol 3-Kinases Host-Pathogen Interactions Virus Replication Immediate-Early Proteins src-Family Kinases The phosphoinositide 3-kinase (PI3K)-Akt pathway is a key signaling cascade regulating diverse cellular processes, including proliferation, survival, autophagy, translation, and metabolism. White spot syndrome virus (WSSV), a major pathogen devastating global crustacean aquaculture, has been demonstrated to exploit the PI3K-Akt pathway to facilitate its proliferation. However, the precise mechanism underlying this viral modulation remained unclear. In this study, we demonstrate that WSSV infection induces activation of the PI3K-Akt pathway during the early infection stage in . Mechanistically, we reveal that the WSSV immediate-early protein IE1 interacts with and activates host Src64B kinase via its YFTS tyrosine motif. This specific interaction promotes recruitment of the PI3K regulatory subunit alpha (PI3Kp85α), thereby triggering the downstream PI3K-Akt signaling. By activating this pathway, WSSV establishes a favorable environment for its proliferation by suppressing host apoptotic and autophagic defenses. Our findings unveil a previously unknown mechanism of WSSV immune evasion through Src-PI3K-Akt signaling hijacking and identify components of this signaling hub as potential therapeutic targets for anti-WSSV strategies. Viruses usually hijack host signaling pathways to enhance infectivity and evade immune defenses. Understanding these interactions is critical for elucidating viral pathogenesis and developing effective antiviral strategies. Here, we demonstrate that the WSSV immediate-early protein IE1 binds to and activates host Src64B kinase, which in turn recruits PI3Kp85α and activates the PI3K-Akt signaling cascade. Activation of this pathway suppresses apoptosis and autophagy, thereby facilitating viral proliferation. These findings advance our understanding of WSSV pathogenesis and identify the Src-PI3K-Akt signaling as a promising therapeutic target for anti-WSSV intervention. |
| title | Hijacking of host Src-PI3K-Akt signaling by WSSV IE1 protein suppresses apoptotic and autophagic defenses to facilitate viral proliferation. |
| topic | Animals Signal Transduction Proto-Oncogene Proteins c-akt Penaeidae Apoptosis White spot syndrome virus 1 Autophagy Phosphatidylinositol 3-Kinases Host-Pathogen Interactions Virus Replication Immediate-Early Proteins src-Family Kinases |
| url | https://pubmed.ncbi.nlm.nih.gov/41400355/ |