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| Autori principali: | , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Journal of natural products
2026
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/41404783/ |
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| _version_ | 1868266111376556033 |
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| author | Ban, Zi-Wei Yao, Fei-Hua Luo, Lian-Xiang Hu, Liang-Rui Qi, Shu-Hua |
| author_facet | Ban, Zi-Wei Yao, Fei-Hua Luo, Lian-Xiang Hu, Liang-Rui Qi, Shu-Hua Ban, Zi-Wei Yao, Fei-Hua Luo, Lian-Xiang Hu, Liang-Rui Qi, Shu-Hua |
| collection | PubMed - marine biology |
| contents | Antibacterial and Cytotoxic Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus sp. SCSIO 41512. Ban, Zi-Wei Yao, Fei-Hua Luo, Lian-Xiang Hu, Liang-Rui Qi, Shu-Hua Penicillium Humans Alkaloids Anti-Bacterial Agents Molecular Structure Microbial Sensitivity Tests Drug Screening Assays, Antitumor Antineoplastic Agents Structure-Activity Relationship HCT116 Cells A549 Cells Fluorenes Crystallography, X-Ray Marine Biology Eight new decahydrofluorene-class alkaloids, pyrrospirones R-Y (-), together with 13 known analogues (921) were isolated from the marine-derived fungal strain sp. SCSIO 41512. Their structures were determined by extensive spectroscopic analysis, and their absolute configurations were established by quantum chemical calculations of electronic circular dichroism (ECD) spectra, by a comparison of experimental ECD spectra, or by single-crystal X-ray diffraction analysis. Compound rarely contains an oxime hydroxy with a 6/5/6/5/6/13 polycyclic system. A plausible biosynthetic pathway for and was proposed. Biologically, compounds , , , , -, -, -, and had cytotoxicity against human cancer cell lines A549 and HCT116 with IC values of 7.3-79.3 μM, and , , , , , , and also showed significant inhibitory activity against six pathogenic bacteria with MIC values of 1.6-13.0 μg/mL. Their structure-bioactivity relationship was also discussed. |
| format | Artículo científico |
| id | pubmed_41404783 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Journal of natural products |
| record_format | pubmed |
| spellingShingle | Antibacterial and Cytotoxic Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus sp. SCSIO 41512. Ban, Zi-Wei Yao, Fei-Hua Luo, Lian-Xiang Hu, Liang-Rui Qi, Shu-Hua Penicillium Humans Alkaloids Anti-Bacterial Agents Molecular Structure Microbial Sensitivity Tests Drug Screening Assays, Antitumor Antineoplastic Agents Structure-Activity Relationship HCT116 Cells A549 Cells Fluorenes Crystallography, X-Ray Marine Biology Antibacterial and Cytotoxic Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus sp. SCSIO 41512. Ban, Zi-Wei Yao, Fei-Hua Luo, Lian-Xiang Hu, Liang-Rui Qi, Shu-Hua Penicillium Humans Alkaloids Anti-Bacterial Agents Molecular Structure Microbial Sensitivity Tests Drug Screening Assays, Antitumor Antineoplastic Agents Structure-Activity Relationship HCT116 Cells A549 Cells Fluorenes Crystallography, X-Ray Marine Biology Eight new decahydrofluorene-class alkaloids, pyrrospirones R-Y (-), together with 13 known analogues (921) were isolated from the marine-derived fungal strain sp. SCSIO 41512. Their structures were determined by extensive spectroscopic analysis, and their absolute configurations were established by quantum chemical calculations of electronic circular dichroism (ECD) spectra, by a comparison of experimental ECD spectra, or by single-crystal X-ray diffraction analysis. Compound rarely contains an oxime hydroxy with a 6/5/6/5/6/13 polycyclic system. A plausible biosynthetic pathway for and was proposed. Biologically, compounds , , , , -, -, -, and had cytotoxicity against human cancer cell lines A549 and HCT116 with IC values of 7.3-79.3 μM, and , , , , , , and also showed significant inhibitory activity against six pathogenic bacteria with MIC values of 1.6-13.0 μg/mL. Their structure-bioactivity relationship was also discussed. |
| title | Antibacterial and Cytotoxic Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus sp. SCSIO 41512. |
| topic | Penicillium Humans Alkaloids Anti-Bacterial Agents Molecular Structure Microbial Sensitivity Tests Drug Screening Assays, Antitumor Antineoplastic Agents Structure-Activity Relationship HCT116 Cells A549 Cells Fluorenes Crystallography, X-Ray Marine Biology |
| url | https://pubmed.ncbi.nlm.nih.gov/41404783/ |