Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.
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| Natura: | Artículo científico |
| Lingua: | en |
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Current biology : CB
2026
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| _version_ | 1868266111374458880 |
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| author | Herget, Ulrich Tran, Steven Singh, Chanpreet Oikonomou, Grigorios Ryu, Soojin Rotllant, Josep Prober, David A |
| author_facet | Herget, Ulrich Tran, Steven Singh, Chanpreet Oikonomou, Grigorios Ryu, Soojin Rotllant, Josep Prober, David A Herget, Ulrich Tran, Steven Singh, Chanpreet Oikonomou, Grigorios Ryu, Soojin Rotllant, Josep Prober, David A |
| collection | PubMed - marine biology |
| contents | Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons. Herget, Ulrich Tran, Steven Singh, Chanpreet Oikonomou, Grigorios Ryu, Soojin Rotllant, Josep Prober, David A Animals Zebrafish Sleep Neurons Hypothalamus Parathyroid Hormone Zebrafish Proteins Brain Stem Classical studies identified a critical role for the hypothalamus in regulating sleep and wake states, but few such hypothalamic neuronal populations have been identified. Here, we describe a sleep-promoting population of hypothalamic neurons that expresses the neuropeptides QRFP and parathyroid hormone 4 (Pth4) in zebrafish. Optogenetic stimulation of these neurons results in a large increase in sleep that requires pth4 but not qrfp. Noradrenergic locus coeruleus (LC) neurons and serotonergic (5HT) raphe nuclei (RNs) in the hindbrain express distinct pth receptors, and genetic epistasis and cell ablation experiments revealed that Pth4 neuron-induced sleep is suppressed in mutants that lack noradrenaline in the LC or lack the 5HT RNs. Pth4 neuron-induced sleep is also suppressed in serine/threonine kinase 32a (stk32a) mutants, possibly via stk32a-expressing neurons in the prethalamus that express pth receptors. These results identify QRFP/Pth4 neurons as a novel hypothalamic sleep-promoting population and support a model in which distinct sleep- and wake-promoting hypothalamic populations act via monoaminergic neurons in the hindbrain to control vigilance state. |
| format | Artículo científico |
| id | pubmed_41406966 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Current biology : CB |
| record_format | pubmed |
| spellingShingle | Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons. Herget, Ulrich Tran, Steven Singh, Chanpreet Oikonomou, Grigorios Ryu, Soojin Rotllant, Josep Prober, David A Animals Zebrafish Sleep Neurons Hypothalamus Parathyroid Hormone Zebrafish Proteins Brain Stem Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons. Herget, Ulrich Tran, Steven Singh, Chanpreet Oikonomou, Grigorios Ryu, Soojin Rotllant, Josep Prober, David A Animals Zebrafish Sleep Neurons Hypothalamus Parathyroid Hormone Zebrafish Proteins Brain Stem Classical studies identified a critical role for the hypothalamus in regulating sleep and wake states, but few such hypothalamic neuronal populations have been identified. Here, we describe a sleep-promoting population of hypothalamic neurons that expresses the neuropeptides QRFP and parathyroid hormone 4 (Pth4) in zebrafish. Optogenetic stimulation of these neurons results in a large increase in sleep that requires pth4 but not qrfp. Noradrenergic locus coeruleus (LC) neurons and serotonergic (5HT) raphe nuclei (RNs) in the hindbrain express distinct pth receptors, and genetic epistasis and cell ablation experiments revealed that Pth4 neuron-induced sleep is suppressed in mutants that lack noradrenaline in the LC or lack the 5HT RNs. Pth4 neuron-induced sleep is also suppressed in serine/threonine kinase 32a (stk32a) mutants, possibly via stk32a-expressing neurons in the prethalamus that express pth receptors. These results identify QRFP/Pth4 neurons as a novel hypothalamic sleep-promoting population and support a model in which distinct sleep- and wake-promoting hypothalamic populations act via monoaminergic neurons in the hindbrain to control vigilance state. |
| title | Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons. |
| topic | Animals Zebrafish Sleep Neurons Hypothalamus Parathyroid Hormone Zebrafish Proteins Brain Stem |
| url | https://pubmed.ncbi.nlm.nih.gov/41406966/ |