Enregistré dans:
| Auteurs principaux: | , , |
|---|---|
| Format: | Artículo científico |
| Langue: | en |
| Publié: |
International journal of biological macromolecules
2026
|
| Sujets: | |
| Accès en ligne: | https://pubmed.ncbi.nlm.nih.gov/41418957/ |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1868266108350365696 |
|---|---|
| author | Qiu, Songlin Hu, Shicheng Jiao, Yingchun |
| author_facet | Qiu, Songlin Hu, Shicheng Jiao, Yingchun Qiu, Songlin Hu, Shicheng Jiao, Yingchun |
| collection | PubMed - marine biology |
| contents | Hypoxic adaptation mechanism of polysaccharide from Agaricus bitorquis (Quél.) Sacc.Chaidam on gut microbiota in Tibetan Plateau population based on in vitro model. Qiu, Songlin Hu, Shicheng Jiao, Yingchun Agaricus Gastrointestinal Microbiome Polysaccharides Fatty Acids, Volatile Humans Tibet Adaptation, Physiological Altitude Fermentation Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia The intercellular polysaccharides derived from Agaricus bitorquis (Quél.) Sacc. Chaidam (ABIPs) are macromolecules exhibiting significant biological activity and outstanding anti-hypoxia properties. However, the digestive traits of ABIPs within the intestinal microbiota and their adaptive mechanisms to hypoxia in high-altitude populations remain poorly understood. The objective of this study was to investigate the anti-hypoxia mechanism of ABIPs at the small-molecule level through the utilization of the in vitro fermentation model of intestinal flora and the cell hypoxia models. The results indicated that under conditions of hypoxic stress, the total amount of monosaccharides and uronic acids (MUAs) metabolized by ABIPs in the plateau group was comparatively high, predominantly mannose. Furthermore, the level of short-chain fatty acids (SCFAs) produced through their metabolism was also significantly higher than that of the plain group, with acetic-acid, propionic-acid, and butyric-acid constituting a relatively large proportion. Additionally, in the plateau group, the metabolism of ABIPs increased the abundance of Prevotella and Alloprevotella, while the abundance of Collinsella decreased notably. In contrast, the metabolites produced by ABIPs in the plateau group (mainly SCFAs) had a more pronounced inhibitory effect on the hypoxia-inducible factor-1α (HIF-1α) signaling pathway than in the plain group. Overall, ABIPs may enable cells to develop hypoxia tolerance by enhancing hypoxia-consuming metabolic levels, rebalancing the gut microbiota, and stabilizing the HIF-1α signaling pathway, thereby protecting the body from hypoxia damage. |
| format | Artículo científico |
| id | pubmed_41418957 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | International journal of biological macromolecules |
| record_format | pubmed |
| spellingShingle | Hypoxic adaptation mechanism of polysaccharide from Agaricus bitorquis (Quél.) Sacc.Chaidam on gut microbiota in Tibetan Plateau population based on in vitro model. Qiu, Songlin Hu, Shicheng Jiao, Yingchun Agaricus Gastrointestinal Microbiome Polysaccharides Fatty Acids, Volatile Humans Tibet Adaptation, Physiological Altitude Fermentation Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia Hypoxic adaptation mechanism of polysaccharide from Agaricus bitorquis (Quél.) Sacc.Chaidam on gut microbiota in Tibetan Plateau population based on in vitro model. Qiu, Songlin Hu, Shicheng Jiao, Yingchun Agaricus Gastrointestinal Microbiome Polysaccharides Fatty Acids, Volatile Humans Tibet Adaptation, Physiological Altitude Fermentation Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia The intercellular polysaccharides derived from Agaricus bitorquis (Quél.) Sacc. Chaidam (ABIPs) are macromolecules exhibiting significant biological activity and outstanding anti-hypoxia properties. However, the digestive traits of ABIPs within the intestinal microbiota and their adaptive mechanisms to hypoxia in high-altitude populations remain poorly understood. The objective of this study was to investigate the anti-hypoxia mechanism of ABIPs at the small-molecule level through the utilization of the in vitro fermentation model of intestinal flora and the cell hypoxia models. The results indicated that under conditions of hypoxic stress, the total amount of monosaccharides and uronic acids (MUAs) metabolized by ABIPs in the plateau group was comparatively high, predominantly mannose. Furthermore, the level of short-chain fatty acids (SCFAs) produced through their metabolism was also significantly higher than that of the plain group, with acetic-acid, propionic-acid, and butyric-acid constituting a relatively large proportion. Additionally, in the plateau group, the metabolism of ABIPs increased the abundance of Prevotella and Alloprevotella, while the abundance of Collinsella decreased notably. In contrast, the metabolites produced by ABIPs in the plateau group (mainly SCFAs) had a more pronounced inhibitory effect on the hypoxia-inducible factor-1α (HIF-1α) signaling pathway than in the plain group. Overall, ABIPs may enable cells to develop hypoxia tolerance by enhancing hypoxia-consuming metabolic levels, rebalancing the gut microbiota, and stabilizing the HIF-1α signaling pathway, thereby protecting the body from hypoxia damage. |
| title | Hypoxic adaptation mechanism of polysaccharide from Agaricus bitorquis (Quél.) Sacc.Chaidam on gut microbiota in Tibetan Plateau population based on in vitro model. |
| topic | Agaricus Gastrointestinal Microbiome Polysaccharides Fatty Acids, Volatile Humans Tibet Adaptation, Physiological Altitude Fermentation Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia |
| url | https://pubmed.ncbi.nlm.nih.gov/41418957/ |