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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Phytochemistry
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41419121/ |
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| _version_ | 1868266108349317121 |
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| author | Luu, Phuong Vu Phan, Thuy-Tien Thi Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Ton-Nu, Huong Lien Lee, Mei-Hsien Shen, Yao-An Fan, Yu-Jui Chang, Yu-Chia Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung |
| author_facet | Luu, Phuong Vu Phan, Thuy-Tien Thi Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Ton-Nu, Huong Lien Lee, Mei-Hsien Shen, Yao-An Fan, Yu-Jui Chang, Yu-Chia Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Luu, Phuong Vu Phan, Thuy-Tien Thi Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Ton-Nu, Huong Lien Lee, Mei-Hsien Shen, Yao-An Fan, Yu-Jui Chang, Yu-Chia Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung |
| collection | PubMed - marine biology |
| contents | Sclerohumins G-L: Selective cytotoxic diterpenoids featuring a 4/9-fused ring system from the soft coral Sclerophytum humesi. Luu, Phuong Vu Phan, Thuy-Tien Thi Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Ton-Nu, Huong Lien Lee, Mei-Hsien Shen, Yao-An Fan, Yu-Jui Chang, Yu-Chia Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Anthozoa Animals Diterpenes Drug Screening Assays, Antitumor Molecular Structure Structure-Activity Relationship Humans Antineoplastic Agents Cell Line, Tumor Dose-Response Relationship, Drug Cell Proliferation Eight previously undescribed terpenoids, including six xeniaphyllane-derived diterpenoids, sclerohumins G-L (1-6), and two norcaryophyllene-type sesquiterpene isomers, norsclerohumins M and N (7 and 8), were isolated from the soft coral Sclerophytum humesi by MIMN-guided isolation. These compounds feature a 4/9-fused ring system, which was first isolated from the genus Sclerophytum. Moreover, compound 6 possesses a 20-exomethylene moiety, which is uncommon among xeniaphyllane-type diterpenoids. Their structures were elucidated through their spectroscopic analysis, including NMR, HR-ESI-MS, ECD, and DP4+ probability assessments. All isolates were tested for their cytotoxic activities, revealing that compounds 1-5 exhibited selective cytotoxicity in the MIA PaCa-2 cell line with IC values ranging from 9.0 to 26.1 μM and selective index (SI) greater than 3. The structure-activity relationships (SARs) of these active compounds were further investigated, providing insights into the molecular features that modulate cytotoxic efficacy. Additionally, a plausible biosynthetic pathway of compounds 1-6 was proposed, demonstrating the soft coral Sclerophytum humesi as a rich source of novel natural products. |
| format | Artículo científico |
| id | pubmed_41419121 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Phytochemistry |
| record_format | pubmed |
| spellingShingle | Sclerohumins G-L: Selective cytotoxic diterpenoids featuring a 4/9-fused ring system from the soft coral Sclerophytum humesi. Luu, Phuong Vu Phan, Thuy-Tien Thi Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Ton-Nu, Huong Lien Lee, Mei-Hsien Shen, Yao-An Fan, Yu-Jui Chang, Yu-Chia Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Anthozoa Animals Diterpenes Drug Screening Assays, Antitumor Molecular Structure Structure-Activity Relationship Humans Antineoplastic Agents Cell Line, Tumor Dose-Response Relationship, Drug Cell Proliferation Sclerohumins G-L: Selective cytotoxic diterpenoids featuring a 4/9-fused ring system from the soft coral Sclerophytum humesi. Luu, Phuong Vu Phan, Thuy-Tien Thi Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Ton-Nu, Huong Lien Lee, Mei-Hsien Shen, Yao-An Fan, Yu-Jui Chang, Yu-Chia Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Anthozoa Animals Diterpenes Drug Screening Assays, Antitumor Molecular Structure Structure-Activity Relationship Humans Antineoplastic Agents Cell Line, Tumor Dose-Response Relationship, Drug Cell Proliferation Eight previously undescribed terpenoids, including six xeniaphyllane-derived diterpenoids, sclerohumins G-L (1-6), and two norcaryophyllene-type sesquiterpene isomers, norsclerohumins M and N (7 and 8), were isolated from the soft coral Sclerophytum humesi by MIMN-guided isolation. These compounds feature a 4/9-fused ring system, which was first isolated from the genus Sclerophytum. Moreover, compound 6 possesses a 20-exomethylene moiety, which is uncommon among xeniaphyllane-type diterpenoids. Their structures were elucidated through their spectroscopic analysis, including NMR, HR-ESI-MS, ECD, and DP4+ probability assessments. All isolates were tested for their cytotoxic activities, revealing that compounds 1-5 exhibited selective cytotoxicity in the MIA PaCa-2 cell line with IC values ranging from 9.0 to 26.1 μM and selective index (SI) greater than 3. The structure-activity relationships (SARs) of these active compounds were further investigated, providing insights into the molecular features that modulate cytotoxic efficacy. Additionally, a plausible biosynthetic pathway of compounds 1-6 was proposed, demonstrating the soft coral Sclerophytum humesi as a rich source of novel natural products. |
| title | Sclerohumins G-L: Selective cytotoxic diterpenoids featuring a 4/9-fused ring system from the soft coral Sclerophytum humesi. |
| topic | Anthozoa Animals Diterpenes Drug Screening Assays, Antitumor Molecular Structure Structure-Activity Relationship Humans Antineoplastic Agents Cell Line, Tumor Dose-Response Relationship, Drug Cell Proliferation |
| url | https://pubmed.ncbi.nlm.nih.gov/41419121/ |