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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Phytochemistry
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41422855/ |
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| _version_ | 1868266108339879938 |
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| author | Pham, Quoc-Vu Chang, Yu-Chia Cheng, You-Song Chen, Yun-Shiuan Chen, Lo-Yun Lee, Mei-Hsien Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Hwang, Tsong-Long |
| author_facet | Pham, Quoc-Vu Chang, Yu-Chia Cheng, You-Song Chen, Yun-Shiuan Chen, Lo-Yun Lee, Mei-Hsien Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Hwang, Tsong-Long Pham, Quoc-Vu Chang, Yu-Chia Cheng, You-Song Chen, Yun-Shiuan Chen, Lo-Yun Lee, Mei-Hsien Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Hwang, Tsong-Long |
| collection | PubMed - marine biology |
| contents | SMART-assisted discovery of scalaranes from the marine sponge Lendenfeldia sp. and its anti-osteoclastogenesis activity. Pham, Quoc-Vu Chang, Yu-Chia Cheng, You-Song Chen, Yun-Shiuan Chen, Lo-Yun Lee, Mei-Hsien Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Hwang, Tsong-Long Animals Porifera Humans Sesterterpenes Structure-Activity Relationship Molecular Structure Osteogenesis Osteoclasts THP-1 Cells Drug Discovery Dose-Response Relationship, Drug Marine sponges of the genus Lendenfeldia are known as a rich source of scalarane-type sesterterpenoids with diverse biological activities. In the present study, SMART-guided isolation of scalarane-type sesterterpenoids from the marine sponge Lendenfeldia sp. yielded a total of twelve members of this chemical class (1-12), including five previously undescribed compounds, named as lendenborvicins A-E (1-5). The structures of previously undescribed compounds were elucidated through comprehensive spectroscopic analyses, including 1D/2D NMR, HRESIMS, and ECD spectroscopy for the determination of absolute configurations. All isolated compounds were evaluated for their anti-osteoclastogenic activity using a TRAP assay in PMA/RANKL-induced THP-1 cells. Compounds 1, 2, 8, 10, 11, and 12 significantly reduced TRAP activity, with compound 11 exhibiting the strongest effect, decreasing TRAP activity to 64.75 ± 1.37 %. Based on these results, a structure-activity relationship (SAR) was preliminarily analyzed to identify the structural features contributing to the observed biological activity. This study provides the first documented evidence of anti-osteoclastogenic activity among scalarane-type sesterterpenoids. |
| format | Artículo científico |
| id | pubmed_41422855 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Phytochemistry |
| record_format | pubmed |
| spellingShingle | SMART-assisted discovery of scalaranes from the marine sponge Lendenfeldia sp. and its anti-osteoclastogenesis activity. Pham, Quoc-Vu Chang, Yu-Chia Cheng, You-Song Chen, Yun-Shiuan Chen, Lo-Yun Lee, Mei-Hsien Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Hwang, Tsong-Long Animals Porifera Humans Sesterterpenes Structure-Activity Relationship Molecular Structure Osteogenesis Osteoclasts THP-1 Cells Drug Discovery Dose-Response Relationship, Drug SMART-assisted discovery of scalaranes from the marine sponge Lendenfeldia sp. and its anti-osteoclastogenesis activity. Pham, Quoc-Vu Chang, Yu-Chia Cheng, You-Song Chen, Yun-Shiuan Chen, Lo-Yun Lee, Mei-Hsien Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Hwang, Tsong-Long Animals Porifera Humans Sesterterpenes Structure-Activity Relationship Molecular Structure Osteogenesis Osteoclasts THP-1 Cells Drug Discovery Dose-Response Relationship, Drug Marine sponges of the genus Lendenfeldia are known as a rich source of scalarane-type sesterterpenoids with diverse biological activities. In the present study, SMART-guided isolation of scalarane-type sesterterpenoids from the marine sponge Lendenfeldia sp. yielded a total of twelve members of this chemical class (1-12), including five previously undescribed compounds, named as lendenborvicins A-E (1-5). The structures of previously undescribed compounds were elucidated through comprehensive spectroscopic analyses, including 1D/2D NMR, HRESIMS, and ECD spectroscopy for the determination of absolute configurations. All isolated compounds were evaluated for their anti-osteoclastogenic activity using a TRAP assay in PMA/RANKL-induced THP-1 cells. Compounds 1, 2, 8, 10, 11, and 12 significantly reduced TRAP activity, with compound 11 exhibiting the strongest effect, decreasing TRAP activity to 64.75 ± 1.37 %. Based on these results, a structure-activity relationship (SAR) was preliminarily analyzed to identify the structural features contributing to the observed biological activity. This study provides the first documented evidence of anti-osteoclastogenic activity among scalarane-type sesterterpenoids. |
| title | SMART-assisted discovery of scalaranes from the marine sponge Lendenfeldia sp. and its anti-osteoclastogenesis activity. |
| topic | Animals Porifera Humans Sesterterpenes Structure-Activity Relationship Molecular Structure Osteogenesis Osteoclasts THP-1 Cells Drug Discovery Dose-Response Relationship, Drug |
| url | https://pubmed.ncbi.nlm.nih.gov/41422855/ |