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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Chinese journal of natural medicines
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41435589/ |
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Table of Contents:
- Ircinrimanes A-J: ten undescribed rearranged 4,9-friedodrimane merosesquiterpenoids with cytotoxic and anti-inflammatory activities from the marine sponge Ircinia sp. Zhang, Wenjie Ren, Jinjin Zhu, Xiao Li, Xiaobin Tang, Xuli Han, Xiao Li, Guoqiang Animals Zebrafish Anti-Inflammatory Agents Porifera Molecular Structure Sesquiterpenes Humans China Antineoplastic Agents Ten previously undescribed rearranged 4,9-friedodrimane merosesquiterpenoids, designated ircinrimanes A-J (1-10), were isolated from the marine sponge Ircinia sp., collected from the South China Sea. Their structures and absolute configurations were definitively elucidated through a combination of spectroscopic data analysis, DP4+ probability assessments, electronic circular dichroism (ECD) calculations, and Mo(OAc) experiment. Compounds 1-4 contained benzene rings, with compound 1 featuring an unusual 2-carbonyl morpholin ring, while compound 2 possessed a benzoxazole ring. Compounds 5-9 comprised sesquiterpenoid quinones with distinct amino side chains at C-20, and compound 10 incorporated an ethoxy side chain. Notably, compounds 1-10 demonstrated an unusual rearrangement of 4,9-friedodrimane sesquiterpenes. Compounds 2, 5-8 and 10 demonstrated cytotoxic activity, while compound 2 exhibited anti-inflammatory activity in zebrafish.