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| Autori principali: | , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
National science review
2025
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| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/41438675/ |
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| _version_ | 1868266108325199872 |
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| author | Sun, Simian Yang, Shimao Qiu, Yu Ding, Jun Wang, Wanze Wu, Fuqing Chen, Guo-Qiang |
| author_facet | Sun, Simian Yang, Shimao Qiu, Yu Ding, Jun Wang, Wanze Wu, Fuqing Chen, Guo-Qiang Sun, Simian Yang, Shimao Qiu, Yu Ding, Jun Wang, Wanze Wu, Fuqing Chen, Guo-Qiang |
| collection | PubMed - marine biology |
| contents | Life cycle design of polyhydroxyalkanoates (PHA). Sun, Simian Yang, Shimao Qiu, Yu Ding, Jun Wang, Wanze Wu, Fuqing Chen, Guo-Qiang The global plastic crisis demands sustainable polymer design and production across the full life cycle. Polyhydroxyalkanoates (PHAs), a family of biodegradable polyesters produced by microorganisms, provide a representative model for circular material development and applications. This review summarizes advances in microbial chassis engineering, seawater-based biomanufacturing, and low-energy downstream processing that together reduce freshwater use, energy input, and process complexity. The structural versatility of PHA supports applications ranging from compostable packaging to long-term biomedical devices. End-of-life options, including biodegradation, anaerobic digestion, and chemical recycling, enable efficient material recovery, and reintegration into natural carbon cycles. Life cycle assessments consistently show reductions in greenhouse-gas emissions, fossil-resource dependence, and marine eutrophication relative to conventional plastics. Remaining challenges include lowering production costs, improving material performance, and developing standardized biodegradation and circular-economy frameworks. Integration on synthetic biology, materials science, and industrial ecology help shape design principles for sustainable PHA-based polymer systems. |
| format | Artículo científico |
| id | pubmed_41438675 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | National science review |
| record_format | pubmed |
| spellingShingle | Life cycle design of polyhydroxyalkanoates (PHA). Sun, Simian Yang, Shimao Qiu, Yu Ding, Jun Wang, Wanze Wu, Fuqing Chen, Guo-Qiang Life cycle design of polyhydroxyalkanoates (PHA). Sun, Simian Yang, Shimao Qiu, Yu Ding, Jun Wang, Wanze Wu, Fuqing Chen, Guo-Qiang The global plastic crisis demands sustainable polymer design and production across the full life cycle. Polyhydroxyalkanoates (PHAs), a family of biodegradable polyesters produced by microorganisms, provide a representative model for circular material development and applications. This review summarizes advances in microbial chassis engineering, seawater-based biomanufacturing, and low-energy downstream processing that together reduce freshwater use, energy input, and process complexity. The structural versatility of PHA supports applications ranging from compostable packaging to long-term biomedical devices. End-of-life options, including biodegradation, anaerobic digestion, and chemical recycling, enable efficient material recovery, and reintegration into natural carbon cycles. Life cycle assessments consistently show reductions in greenhouse-gas emissions, fossil-resource dependence, and marine eutrophication relative to conventional plastics. Remaining challenges include lowering production costs, improving material performance, and developing standardized biodegradation and circular-economy frameworks. Integration on synthetic biology, materials science, and industrial ecology help shape design principles for sustainable PHA-based polymer systems. |
| title | Life cycle design of polyhydroxyalkanoates (PHA). |
| url | https://pubmed.ncbi.nlm.nih.gov/41438675/ |