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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Phytochemistry
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41448262/ |
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| _version_ | 1868266108306325504 |
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| author | Chen, Lo-Yun Peng, Bo-Rong Huynh, Thanh Hao Chen, You-Ying Chen, Yu-Cheng Pham, Ngoc-Thac Le, Huong-Giang Pham, Quoc-Vu Luu, Phuong Vu Lai, Ying-Mi El-Shazly, Mohamed Hwang, Tsong-Long Lai, Kuei-Hung |
| author_facet | Chen, Lo-Yun Peng, Bo-Rong Huynh, Thanh Hao Chen, You-Ying Chen, Yu-Cheng Pham, Ngoc-Thac Le, Huong-Giang Pham, Quoc-Vu Luu, Phuong Vu Lai, Ying-Mi El-Shazly, Mohamed Hwang, Tsong-Long Lai, Kuei-Hung Chen, Lo-Yun Peng, Bo-Rong Huynh, Thanh Hao Chen, You-Ying Chen, Yu-Cheng Pham, Ngoc-Thac Le, Huong-Giang Pham, Quoc-Vu Luu, Phuong Vu Lai, Ying-Mi El-Shazly, Mohamed Hwang, Tsong-Long Lai, Kuei-Hung |
| collection | PubMed - marine biology |
| contents | Briarane-type diterpenes from a closed-system cultured soft coral Briareum stechei. Chen, Lo-Yun Peng, Bo-Rong Huynh, Thanh Hao Chen, You-Ying Chen, Yu-Cheng Pham, Ngoc-Thac Le, Huong-Giang Pham, Quoc-Vu Luu, Phuong Vu Lai, Ying-Mi El-Shazly, Mohamed Hwang, Tsong-Long Lai, Kuei-Hung Diterpenes Anthozoa Animals Humans Molecular Structure Neutrophils Pancreatic Elastase Crystallography, X-Ray Superoxides Anti-Inflammatory Agents Molecular Conformation Structure-Activity Relationship In this study, by using untargeted LC-MS/MS-based multi-informative molecular networking, 12 briarane diterpenoids were isolated from a closed-system cultured soft coral Briareum stechei. Among them, six unreported compounds were identified and named briastechols A-F (1-6). Notably, briastechols A (1) and B (2) possess a rare 11,14-ether bridge, while briastechols C (3) and D (4) feature a tetrahydrofuran moiety with an ether linkage between C-5 and C-8. Additionally, the absolute configurations of briastechol F (6) and briarenol H (10) were determined for the first time via X-ray crystallographic analysis. Evaluation of bioactivity indicated that the crude extract exerted pronounced anti-inflammatory effects, as reflected in the inhibition of superoxide anion formation and elastase secretion in human neutrophils triggered by N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB). Among the isolated compounds, briastechol E (5) showed significant anti-inflammatory potential, with IC values of 7.89 ± 0.38 μM and 4.53 ± 0.68 μM against superoxide anion generation and elastase release, respectively. These findings underscore the structural novelty and chemical diversity of metabolites from cultured B. stechei using a closed system, highlighting its potential as a sustainable source of anti-inflammatory agents and further supporting the viability of closed aquaculture systems for marine natural product research. |
| format | Artículo científico |
| id | pubmed_41448262 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Phytochemistry |
| record_format | pubmed |
| spellingShingle | Briarane-type diterpenes from a closed-system cultured soft coral Briareum stechei. Chen, Lo-Yun Peng, Bo-Rong Huynh, Thanh Hao Chen, You-Ying Chen, Yu-Cheng Pham, Ngoc-Thac Le, Huong-Giang Pham, Quoc-Vu Luu, Phuong Vu Lai, Ying-Mi El-Shazly, Mohamed Hwang, Tsong-Long Lai, Kuei-Hung Diterpenes Anthozoa Animals Humans Molecular Structure Neutrophils Pancreatic Elastase Crystallography, X-Ray Superoxides Anti-Inflammatory Agents Molecular Conformation Structure-Activity Relationship Briarane-type diterpenes from a closed-system cultured soft coral Briareum stechei. Chen, Lo-Yun Peng, Bo-Rong Huynh, Thanh Hao Chen, You-Ying Chen, Yu-Cheng Pham, Ngoc-Thac Le, Huong-Giang Pham, Quoc-Vu Luu, Phuong Vu Lai, Ying-Mi El-Shazly, Mohamed Hwang, Tsong-Long Lai, Kuei-Hung Diterpenes Anthozoa Animals Humans Molecular Structure Neutrophils Pancreatic Elastase Crystallography, X-Ray Superoxides Anti-Inflammatory Agents Molecular Conformation Structure-Activity Relationship In this study, by using untargeted LC-MS/MS-based multi-informative molecular networking, 12 briarane diterpenoids were isolated from a closed-system cultured soft coral Briareum stechei. Among them, six unreported compounds were identified and named briastechols A-F (1-6). Notably, briastechols A (1) and B (2) possess a rare 11,14-ether bridge, while briastechols C (3) and D (4) feature a tetrahydrofuran moiety with an ether linkage between C-5 and C-8. Additionally, the absolute configurations of briastechol F (6) and briarenol H (10) were determined for the first time via X-ray crystallographic analysis. Evaluation of bioactivity indicated that the crude extract exerted pronounced anti-inflammatory effects, as reflected in the inhibition of superoxide anion formation and elastase secretion in human neutrophils triggered by N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB). Among the isolated compounds, briastechol E (5) showed significant anti-inflammatory potential, with IC values of 7.89 ± 0.38 μM and 4.53 ± 0.68 μM against superoxide anion generation and elastase release, respectively. These findings underscore the structural novelty and chemical diversity of metabolites from cultured B. stechei using a closed system, highlighting its potential as a sustainable source of anti-inflammatory agents and further supporting the viability of closed aquaculture systems for marine natural product research. |
| title | Briarane-type diterpenes from a closed-system cultured soft coral Briareum stechei. |
| topic | Diterpenes Anthozoa Animals Humans Molecular Structure Neutrophils Pancreatic Elastase Crystallography, X-Ray Superoxides Anti-Inflammatory Agents Molecular Conformation Structure-Activity Relationship |
| url | https://pubmed.ncbi.nlm.nih.gov/41448262/ |