Immunosuppressive effects of dexamethasone on spleen and head kidney cells from Arabian Sea bream (): model of environmental pharmaceutical pollution.
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| Main Authors: | , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Immunopharmacology and immunotoxicology
2026
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| _version_ | 1868266108305276928 |
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| author | Nozhat, Fatemeh Salamat, Negin Salarialiabadi, Mohammad Ali Mojiri-Forushani, Hoda Morovvati, Hassan |
| author_facet | Nozhat, Fatemeh Salamat, Negin Salarialiabadi, Mohammad Ali Mojiri-Forushani, Hoda Morovvati, Hassan Nozhat, Fatemeh Salamat, Negin Salarialiabadi, Mohammad Ali Mojiri-Forushani, Hoda Morovvati, Hassan |
| collection | PubMed - marine biology |
| contents | Immunosuppressive effects of dexamethasone on spleen and head kidney cells from Arabian Sea bream (): model of environmental pharmaceutical pollution. Nozhat, Fatemeh Salamat, Negin Salarialiabadi, Mohammad Ali Mojiri-Forushani, Hoda Morovvati, Hassan Animals Dexamethasone Head Kidney Spleen Immunosuppressive Agents Water Pollutants, Chemical Sea Bream Immunity, Innate Cells, Cultured Immunoglobulin M Pharmaceuticals are emerging pollutants that have received great interest because of their discharge into aquatic ecosystems through wastewater worldwide. However, studies on the effects of these pollutants on aquatic animals are limited. Dexamethasone is a potent synthetic glucocorticoid with anti-inflammatory and immunosuppressive effects. Understanding how this medicine affects the immune response of fish was the topic of interest in the present study. The present study investigated the effects of dexamethasone on the innate immune response of the spleen and head kidney cells of . Cultured spleen and head kidney cells were exposed to dexamethasone with various concentrations . After 48 h, the toxic effects of dexamethasone on innate immune factors were assessed. Based on the results, the sensitivity of cultured spleen and head kidney cells to dexamethasone increased in a concentration-dependent manner. Dexamethasone significantly decreased the number of IgM-secreting cells and IgM secretion. It also significantly reduced the C3 content of the cultivated cells but did not significantly alter the C4 and ACH50 contents or lysozyme activity of the cultivated cells. Furthermore, dexamethasone significantly suppressed respiratory burst activity and nitric oxide production in the spleen and head kidney cells. In conclusion, the immunosuppressive effect of dexamethasone was due mainly to its suppressive effects on IgM-secreting cells and IgM production, C3 content, burst activity and nitric oxide production in the spleen and head kidney cells. |
| format | Artículo científico |
| id | pubmed_41450016 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Immunopharmacology and immunotoxicology |
| record_format | pubmed |
| spellingShingle | Immunosuppressive effects of dexamethasone on spleen and head kidney cells from Arabian Sea bream (): model of environmental pharmaceutical pollution. Nozhat, Fatemeh Salamat, Negin Salarialiabadi, Mohammad Ali Mojiri-Forushani, Hoda Morovvati, Hassan Animals Dexamethasone Head Kidney Spleen Immunosuppressive Agents Water Pollutants, Chemical Sea Bream Immunity, Innate Cells, Cultured Immunoglobulin M Immunosuppressive effects of dexamethasone on spleen and head kidney cells from Arabian Sea bream (): model of environmental pharmaceutical pollution. Nozhat, Fatemeh Salamat, Negin Salarialiabadi, Mohammad Ali Mojiri-Forushani, Hoda Morovvati, Hassan Animals Dexamethasone Head Kidney Spleen Immunosuppressive Agents Water Pollutants, Chemical Sea Bream Immunity, Innate Cells, Cultured Immunoglobulin M Pharmaceuticals are emerging pollutants that have received great interest because of their discharge into aquatic ecosystems through wastewater worldwide. However, studies on the effects of these pollutants on aquatic animals are limited. Dexamethasone is a potent synthetic glucocorticoid with anti-inflammatory and immunosuppressive effects. Understanding how this medicine affects the immune response of fish was the topic of interest in the present study. The present study investigated the effects of dexamethasone on the innate immune response of the spleen and head kidney cells of . Cultured spleen and head kidney cells were exposed to dexamethasone with various concentrations . After 48 h, the toxic effects of dexamethasone on innate immune factors were assessed. Based on the results, the sensitivity of cultured spleen and head kidney cells to dexamethasone increased in a concentration-dependent manner. Dexamethasone significantly decreased the number of IgM-secreting cells and IgM secretion. It also significantly reduced the C3 content of the cultivated cells but did not significantly alter the C4 and ACH50 contents or lysozyme activity of the cultivated cells. Furthermore, dexamethasone significantly suppressed respiratory burst activity and nitric oxide production in the spleen and head kidney cells. In conclusion, the immunosuppressive effect of dexamethasone was due mainly to its suppressive effects on IgM-secreting cells and IgM production, C3 content, burst activity and nitric oxide production in the spleen and head kidney cells. |
| title | Immunosuppressive effects of dexamethasone on spleen and head kidney cells from Arabian Sea bream (): model of environmental pharmaceutical pollution. |
| topic | Animals Dexamethasone Head Kidney Spleen Immunosuppressive Agents Water Pollutants, Chemical Sea Bream Immunity, Innate Cells, Cultured Immunoglobulin M |
| url | https://pubmed.ncbi.nlm.nih.gov/41450016/ |