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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Analytical chemistry
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41454853/ |
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Table of Contents:
- Janus Metal-AIEgen Framework@Hydrogel Patch for Ultrasensitive, Multivariate Responsive, and Intelligent Point-Of-Care Sensors. Hu, Chen Liang, Axin Du, Shujie Gao, Nana Feng, Niu Li, Ying Zheng, Guanghui Fu, Rongxin Zhang, Shuailong Wang, Dou Luo, Aiqin Chen, Yiping Zhang, Jiangjiang Hydrogels Staphylococcus aureus Metal-Organic Frameworks Point-of-Care Systems Limit of Detection Point-of-Care Testing Humans Biosensing Techniques Point-of-care testing (POCT) techniques showcase convenience, low cost, and broad applications in public security and laboratory medicine. Hydrogel-based POCT has drawn great interest because of its improved stability and interference resistance. Here, we synthesize high quantum yield metal-AIEgen frameworks (MAFs) and explore stacking heterogeneous hydrogel thin film complexes to prepare a Janus hydrogel patch for multianalyte and ultrasensitive intelligent POCT sensors. The aqueous swelling difference renders the Janus hydrogel patch with physical self-sorting behavior for image-based digital recognition. Combined with the fluorescence encoding capacity of MAFs, the Janus hydrogel patch achieves fast digital sensing of multianalytes based on customized mobile app-actuated image recognition arithmetic, for example, the intelligent determination of four halide ions. Owing to excellent sensing performance, we develop the hydrogel patch coupling with a nonenzymic dual cascade amplification system (HO-I) for ultrasensitive pathogen detection. The limit of detection is 3 CFU/mL for , staying at the same level compared with enzymic nucleic acid tests but over 100 times more sensitive than other chromogenic/fluorimetric sensors. Clinical bacterial strain tests showed 100% accuracy ( = 28). Fluorescent MAF@hydrogel patch-based ultrasensitive and intelligent digital sensing represents a powerful and convenient POCT platform for developing multiplex and ultrasensitive biochemical sensors from ions to cells.