[Generation of antibody diversity in mammals: mechanisms and synthetic biology applications].
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PubMed
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| Autori principali: | , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
2025
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| _version_ | 1868266105559056385 |
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| author | Huang, Ziwen Hu, Yiheng Yan, Peiyang Yuan, Shaochun Xu, Anlong |
| author_facet | Huang, Ziwen Hu, Yiheng Yan, Peiyang Yuan, Shaochun Xu, Anlong Huang, Ziwen Hu, Yiheng Yan, Peiyang Yuan, Shaochun Xu, Anlong |
| collection | PubMed - marine biology |
| contents | [Generation of antibody diversity in mammals: mechanisms and synthetic biology applications]. Huang, Ziwen Hu, Yiheng Yan, Peiyang Yuan, Shaochun Xu, Anlong Synthetic Biology Animals Mammals Antibody Diversity Humans Cytidine Deaminase Immunoglobulins are adaptive immune effector molecules unique to jawed vertebrates. Their remarkable diversity relies on mechanisms including V(D)J recombination, somatic hypermutation, and class switch recombination. These processes are orchestrated by a variety of key enzymes, such as recombination-activating gene proteins, terminal deoxynucleotidyl transferase (TdT), activation-induced cytidine deaminase, and DNA glycosylases. These enzymes not only play critical roles in the formation of antigen receptor diversity but have also been widely developed as useful tools for basic biological research. This review summarizes the molecular mechanisms underlying antigen receptor diversification in mammals, discusses recent progress in antibody screening and application, and highlights the latest advances in the use of TdT, cytidine deaminases, and DNA glycosylases in synthetic biology. These studies provide important theoretical support and new directions for fundamental research and technological innovation in biotechnology and medicine. |
| format | Artículo científico |
| id | pubmed_41457603 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Sheng wu gong cheng xue bao = Chinese journal of biotechnology |
| record_format | pubmed |
| spellingShingle | [Generation of antibody diversity in mammals: mechanisms and synthetic biology applications]. Huang, Ziwen Hu, Yiheng Yan, Peiyang Yuan, Shaochun Xu, Anlong Synthetic Biology Animals Mammals Antibody Diversity Humans Cytidine Deaminase [Generation of antibody diversity in mammals: mechanisms and synthetic biology applications]. Huang, Ziwen Hu, Yiheng Yan, Peiyang Yuan, Shaochun Xu, Anlong Synthetic Biology Animals Mammals Antibody Diversity Humans Cytidine Deaminase Immunoglobulins are adaptive immune effector molecules unique to jawed vertebrates. Their remarkable diversity relies on mechanisms including V(D)J recombination, somatic hypermutation, and class switch recombination. These processes are orchestrated by a variety of key enzymes, such as recombination-activating gene proteins, terminal deoxynucleotidyl transferase (TdT), activation-induced cytidine deaminase, and DNA glycosylases. These enzymes not only play critical roles in the formation of antigen receptor diversity but have also been widely developed as useful tools for basic biological research. This review summarizes the molecular mechanisms underlying antigen receptor diversification in mammals, discusses recent progress in antibody screening and application, and highlights the latest advances in the use of TdT, cytidine deaminases, and DNA glycosylases in synthetic biology. These studies provide important theoretical support and new directions for fundamental research and technological innovation in biotechnology and medicine. |
| title | [Generation of antibody diversity in mammals: mechanisms and synthetic biology applications]. |
| topic | Synthetic Biology Animals Mammals Antibody Diversity Humans Cytidine Deaminase |
| url | https://pubmed.ncbi.nlm.nih.gov/41457603/ |