Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
ISME communications
2025
|
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41459349/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266105556959233 |
|---|---|
| author | Nandi, Shrinivas Stephens, Timothy G Walsh, Kasey García-Camps, Rebecca Villalpando, Maria F Sellares-Blasco, Rita I Zubillaga, Ainhoa L Croquer, Aldo Bhattacharya, Debashish |
| author_facet | Nandi, Shrinivas Stephens, Timothy G Walsh, Kasey García-Camps, Rebecca Villalpando, Maria F Sellares-Blasco, Rita I Zubillaga, Ainhoa L Croquer, Aldo Bhattacharya, Debashish Nandi, Shrinivas Stephens, Timothy G Walsh, Kasey García-Camps, Rebecca Villalpando, Maria F Sellares-Blasco, Rita I Zubillaga, Ainhoa L Croquer, Aldo Bhattacharya, Debashish |
| collection | PubMed - marine biology |
| contents | Shifts in the microbiome and virome are associated with stony coral tissue loss disease (SCTLD). Nandi, Shrinivas Stephens, Timothy G Walsh, Kasey García-Camps, Rebecca Villalpando, Maria F Sellares-Blasco, Rita I Zubillaga, Ainhoa L Croquer, Aldo Bhattacharya, Debashish Stony coral tissue loss disease (SCTLD) is a rapidly spreading lethal coral disease, the etiology of which remains poorly understood. In this study, using deep metagenomic sequencing, we investigated microbial and viral community dynamics associated with SCTLD progression in the Caribbean stony coral . We assembled 264 metagenome-assembled genomes and correlated their abundance with disease phenotypes, which revealed significant shifts in both the prokaryotic microbiome and virome. Our results provide clear evidence of microbial destabilization in diseased corals, suggesting that microbial dysbiosis is an outcome of SCTLD progression. We identified DNA viruses in our dataset that increase in abundance in SCTLD-affected corals and are present in existing coral data from other Caribbean regions. In addition, we identified the first putative instance of asymptomatic/resistant SCTLD-affected corals. These are apparently healthy colonies that share the viral profile of diseased individuals. However, these colonies contain a different prokaryotic microbiome than do diseased corals, suggesting microbe-induced resilience (i.e. beneficial microbiome) to SCTLD. Finally, utilizing differential abundance analysis and gene inventories, we propose a mechanistic model of SCTLD progression, in which viral dynamics may contribute to microbiome collapse. These findings provide novel insights into SCTLD pathogenesis and offer consistent molecular signals of disease across diverse geographic sites, presenting new opportunities for disease monitoring and mitigation. |
| format | Artículo científico |
| id | pubmed_41459349 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | ISME communications |
| record_format | pubmed |
| spellingShingle | Shifts in the microbiome and virome are associated with stony coral tissue loss disease (SCTLD). Nandi, Shrinivas Stephens, Timothy G Walsh, Kasey García-Camps, Rebecca Villalpando, Maria F Sellares-Blasco, Rita I Zubillaga, Ainhoa L Croquer, Aldo Bhattacharya, Debashish Shifts in the microbiome and virome are associated with stony coral tissue loss disease (SCTLD). Nandi, Shrinivas Stephens, Timothy G Walsh, Kasey García-Camps, Rebecca Villalpando, Maria F Sellares-Blasco, Rita I Zubillaga, Ainhoa L Croquer, Aldo Bhattacharya, Debashish Stony coral tissue loss disease (SCTLD) is a rapidly spreading lethal coral disease, the etiology of which remains poorly understood. In this study, using deep metagenomic sequencing, we investigated microbial and viral community dynamics associated with SCTLD progression in the Caribbean stony coral . We assembled 264 metagenome-assembled genomes and correlated their abundance with disease phenotypes, which revealed significant shifts in both the prokaryotic microbiome and virome. Our results provide clear evidence of microbial destabilization in diseased corals, suggesting that microbial dysbiosis is an outcome of SCTLD progression. We identified DNA viruses in our dataset that increase in abundance in SCTLD-affected corals and are present in existing coral data from other Caribbean regions. In addition, we identified the first putative instance of asymptomatic/resistant SCTLD-affected corals. These are apparently healthy colonies that share the viral profile of diseased individuals. However, these colonies contain a different prokaryotic microbiome than do diseased corals, suggesting microbe-induced resilience (i.e. beneficial microbiome) to SCTLD. Finally, utilizing differential abundance analysis and gene inventories, we propose a mechanistic model of SCTLD progression, in which viral dynamics may contribute to microbiome collapse. These findings provide novel insights into SCTLD pathogenesis and offer consistent molecular signals of disease across diverse geographic sites, presenting new opportunities for disease monitoring and mitigation. |
| title | Shifts in the microbiome and virome are associated with stony coral tissue loss disease (SCTLD). |
| url | https://pubmed.ncbi.nlm.nih.gov/41459349/ |