Bioactivity and Chemical Profiling of the Sea-Ice Microalga (Chlorophyceae).
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| Natura: | Artículo científico |
| Lingua: | en |
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Biomolecules
2025
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| author | Trentin, Riccardo Moschin, Emanuela Custódio, Luísa Moro, Isabella |
| author_facet | Trentin, Riccardo Moschin, Emanuela Custódio, Luísa Moro, Isabella Trentin, Riccardo Moschin, Emanuela Custódio, Luísa Moro, Isabella |
| collection | PubMed - marine biology |
| contents | Bioactivity and Chemical Profiling of the Sea-Ice Microalga (Chlorophyceae). Trentin, Riccardo Moschin, Emanuela Custódio, Luísa Moro, Isabella Microalgae Antioxidants Enzyme Inhibitors Antarctic Regions alpha-Amylases Monophenol Monooxygenase Plant Extracts Methanol Antarctic algae have evolved in extreme environmental conditions, developing unique metabolic adaptations with significant biotechnological potential. In this study, we explored the bioactivity of the sea-ice microalga by preparing acetone and methanol extracts from biomass cultivated at 4, 8, and 16 °C. These extracts were screened for their in vitro antioxidant properties and inhibitory activities on enzymes related to Alzheimer's disease (acetylcholinesterase: AChE, butyrylcholinesterase: BChE), type 2 diabetes mellitus (T2DM, α-glucosidase, α-amylase), obesity (lipase), and hyperpigmentation (tyrosinase). Our screening revealed a high capacity of acetone extracts to scavenge the ABTS• radical (EC ranging from 3.57 to 4.18 mg mL), along with strong copper chelating activity in both acetone and methanol extracts (EC values of 6.31 and 6.41 mg mL). Relevant inhibition towards α-amylase (IC values of 3.34 and 4.53 mg mL) and tyrosinase (with IC ranging from 3.82 to 5.47 mg mL) was reported for acetone and methanol extracts, respectively. UHPLC-HRMS-based profiling revealed the presence of lipidic molecules, such as glycolipids, phospholipids, and betaine lipids with polyunsaturated carbon chains, together with carotenoids, including canthaxanthin and adonixanthin, which are likely responsible for the observed bioactivities. |
| format | Artículo científico |
| id | pubmed_41463314 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Biomolecules |
| record_format | pubmed |
| spellingShingle | Bioactivity and Chemical Profiling of the Sea-Ice Microalga (Chlorophyceae). Trentin, Riccardo Moschin, Emanuela Custódio, Luísa Moro, Isabella Microalgae Antioxidants Enzyme Inhibitors Antarctic Regions alpha-Amylases Monophenol Monooxygenase Plant Extracts Methanol Bioactivity and Chemical Profiling of the Sea-Ice Microalga (Chlorophyceae). Trentin, Riccardo Moschin, Emanuela Custódio, Luísa Moro, Isabella Microalgae Antioxidants Enzyme Inhibitors Antarctic Regions alpha-Amylases Monophenol Monooxygenase Plant Extracts Methanol Antarctic algae have evolved in extreme environmental conditions, developing unique metabolic adaptations with significant biotechnological potential. In this study, we explored the bioactivity of the sea-ice microalga by preparing acetone and methanol extracts from biomass cultivated at 4, 8, and 16 °C. These extracts were screened for their in vitro antioxidant properties and inhibitory activities on enzymes related to Alzheimer's disease (acetylcholinesterase: AChE, butyrylcholinesterase: BChE), type 2 diabetes mellitus (T2DM, α-glucosidase, α-amylase), obesity (lipase), and hyperpigmentation (tyrosinase). Our screening revealed a high capacity of acetone extracts to scavenge the ABTS• radical (EC ranging from 3.57 to 4.18 mg mL), along with strong copper chelating activity in both acetone and methanol extracts (EC values of 6.31 and 6.41 mg mL). Relevant inhibition towards α-amylase (IC values of 3.34 and 4.53 mg mL) and tyrosinase (with IC ranging from 3.82 to 5.47 mg mL) was reported for acetone and methanol extracts, respectively. UHPLC-HRMS-based profiling revealed the presence of lipidic molecules, such as glycolipids, phospholipids, and betaine lipids with polyunsaturated carbon chains, together with carotenoids, including canthaxanthin and adonixanthin, which are likely responsible for the observed bioactivities. |
| title | Bioactivity and Chemical Profiling of the Sea-Ice Microalga (Chlorophyceae). |
| topic | Microalgae Antioxidants Enzyme Inhibitors Antarctic Regions alpha-Amylases Monophenol Monooxygenase Plant Extracts Methanol |
| url | https://pubmed.ncbi.nlm.nih.gov/41463314/ |