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| Main Authors: | , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
International journal of molecular sciences
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41465441/ |
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| _version_ | 1868266105544376321 |
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| author | Seybold, Desmond L Contreras, Gregory P Chang, Jia-Feng Yeh, Ting-Yu |
| author_facet | Seybold, Desmond L Contreras, Gregory P Chang, Jia-Feng Yeh, Ting-Yu Seybold, Desmond L Contreras, Gregory P Chang, Jia-Feng Yeh, Ting-Yu |
| collection | PubMed - marine biology |
| contents | Recent Advances in Biology, Host and Microbe Interactions of the Human Sexually Transmitted Parasite . Seybold, Desmond L Contreras, Gregory P Chang, Jia-Feng Yeh, Ting-Yu Trichomonas vaginalis Humans Trichomonas Infections Host-Parasite Interactions Sexually Transmitted Diseases Female Animals Trichomonas Vaginitis Trichomoniasis is the most common non-viral sexually transmitted infection in humans, with over 200 million people affected each year. This disease is associated with pre-term birth, low birth weight, and premature membrane rupture. Its causal pathogen, (TV), is a prevalent sexually transmitted protozoan parasite that infects the urogenital tract through cytoadherence. TV infection alters TV gene expression and induces host immune responses, while TV-secreted exosomes carry RNA and protein cargoes that mediate extracellular signaling. This review summarizes recent discoveries of molecules that interact with host receptors involved in cytoadherence. We also discuss human innate and adaptive immune responses to TV infection via a variety of inflammatory mediators. Recent research on concurrent or endosymbiont relationships of TV with other urogenital microbes and cancers, is also examined. These studies not only highlight the necessity of understanding host-microbe interactions in TV pathogenesis but also provide a crucial insight into potential therapeutic targets of nitroimidazole-resistant TV strains. |
| format | Artículo científico |
| id | pubmed_41465441 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | International journal of molecular sciences |
| record_format | pubmed |
| spellingShingle | Recent Advances in Biology, Host and Microbe Interactions of the Human Sexually Transmitted Parasite . Seybold, Desmond L Contreras, Gregory P Chang, Jia-Feng Yeh, Ting-Yu Trichomonas vaginalis Humans Trichomonas Infections Host-Parasite Interactions Sexually Transmitted Diseases Female Animals Trichomonas Vaginitis Recent Advances in Biology, Host and Microbe Interactions of the Human Sexually Transmitted Parasite . Seybold, Desmond L Contreras, Gregory P Chang, Jia-Feng Yeh, Ting-Yu Trichomonas vaginalis Humans Trichomonas Infections Host-Parasite Interactions Sexually Transmitted Diseases Female Animals Trichomonas Vaginitis Trichomoniasis is the most common non-viral sexually transmitted infection in humans, with over 200 million people affected each year. This disease is associated with pre-term birth, low birth weight, and premature membrane rupture. Its causal pathogen, (TV), is a prevalent sexually transmitted protozoan parasite that infects the urogenital tract through cytoadherence. TV infection alters TV gene expression and induces host immune responses, while TV-secreted exosomes carry RNA and protein cargoes that mediate extracellular signaling. This review summarizes recent discoveries of molecules that interact with host receptors involved in cytoadherence. We also discuss human innate and adaptive immune responses to TV infection via a variety of inflammatory mediators. Recent research on concurrent or endosymbiont relationships of TV with other urogenital microbes and cancers, is also examined. These studies not only highlight the necessity of understanding host-microbe interactions in TV pathogenesis but also provide a crucial insight into potential therapeutic targets of nitroimidazole-resistant TV strains. |
| title | Recent Advances in Biology, Host and Microbe Interactions of the Human Sexually Transmitted Parasite . |
| topic | Trichomonas vaginalis Humans Trichomonas Infections Host-Parasite Interactions Sexually Transmitted Diseases Female Animals Trichomonas Vaginitis |
| url | https://pubmed.ncbi.nlm.nih.gov/41465441/ |