Extremophile-Derived Bioactives in Cosmeceuticals: Bridging Nutraceuticals and Skincare for Holistic Wellness.

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Main Authors: Maresca, Emanuela, Carbone, Micaela, Gallo, Giovanni, Fusco, Salvatore, Aulitto, Martina
Format: Artículo científico
Language:en
Published: Life (Basel, Switzerland) 2025
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author Maresca, Emanuela
Carbone, Micaela
Gallo, Giovanni
Fusco, Salvatore
Aulitto, Martina
author_facet Maresca, Emanuela
Carbone, Micaela
Gallo, Giovanni
Fusco, Salvatore
Aulitto, Martina
Maresca, Emanuela
Carbone, Micaela
Gallo, Giovanni
Fusco, Salvatore
Aulitto, Martina
collection PubMed - marine biology
contents Extremophile-Derived Bioactives in Cosmeceuticals: Bridging Nutraceuticals and Skincare for Holistic Wellness. Maresca, Emanuela Carbone, Micaela Gallo, Giovanni Fusco, Salvatore Aulitto, Martina The integration of extremophile-derived bioactives into cosmeceuticals and nutricosmetics offers a novel strategy to enhance skin health through both topical and systemic approaches. Extremophile microorganisms, adapted to extreme conditions, produce unique compounds such as , extremozymes, carotenoids, exopolysaccharides (EPSs), and mycosporine-like amino acids (MAAs). These molecules exhibit antioxidant, anti-inflammatory, photoprotective, and regenerative properties. This review analyzes the molecular adaptations that enable extremophiles to synthesize these compounds, and explores their cosmetic applications, including enzymatic exfoliation, UV protection, hydration, and anti-pollution effects. This paper examines their nutraceutical potential, highlighting systemic benefits such as improved skin elasticity, reduced photoaging, and modulation of the gut-skin axis via prebiotic EPSs. Industrial strategies for sustainable production, such as microbial fermentation, synthetic biology, and green extraction, are discussed. Examples of commercial ingredients like PlusXanthin™, Antarctic-G, and Desertica. Extremophile-derived ingredients combine biological efficacy with environmental sustainability, positioning them as key assets for next-generation skincare. Future directions include clinical validation, regulatory harmonization, and the development of personalized, microbiome-friendly formulations.
format Artículo científico
id pubmed_41465727
institution PubMed
language en
publishDate 2025
publisher Life (Basel, Switzerland)
record_format pubmed
spellingShingle Extremophile-Derived Bioactives in Cosmeceuticals: Bridging Nutraceuticals and Skincare for Holistic Wellness.
Maresca, Emanuela
Carbone, Micaela
Gallo, Giovanni
Fusco, Salvatore
Aulitto, Martina
Extremophile-Derived Bioactives in Cosmeceuticals: Bridging Nutraceuticals and Skincare for Holistic Wellness. Maresca, Emanuela Carbone, Micaela Gallo, Giovanni Fusco, Salvatore Aulitto, Martina The integration of extremophile-derived bioactives into cosmeceuticals and nutricosmetics offers a novel strategy to enhance skin health through both topical and systemic approaches. Extremophile microorganisms, adapted to extreme conditions, produce unique compounds such as , extremozymes, carotenoids, exopolysaccharides (EPSs), and mycosporine-like amino acids (MAAs). These molecules exhibit antioxidant, anti-inflammatory, photoprotective, and regenerative properties. This review analyzes the molecular adaptations that enable extremophiles to synthesize these compounds, and explores their cosmetic applications, including enzymatic exfoliation, UV protection, hydration, and anti-pollution effects. This paper examines their nutraceutical potential, highlighting systemic benefits such as improved skin elasticity, reduced photoaging, and modulation of the gut-skin axis via prebiotic EPSs. Industrial strategies for sustainable production, such as microbial fermentation, synthetic biology, and green extraction, are discussed. Examples of commercial ingredients like PlusXanthin™, Antarctic-G, and Desertica. Extremophile-derived ingredients combine biological efficacy with environmental sustainability, positioning them as key assets for next-generation skincare. Future directions include clinical validation, regulatory harmonization, and the development of personalized, microbiome-friendly formulations.
title Extremophile-Derived Bioactives in Cosmeceuticals: Bridging Nutraceuticals and Skincare for Holistic Wellness.
url https://pubmed.ncbi.nlm.nih.gov/41465727/