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| Auteurs principaux: | , , , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Journal of natural products
2026
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| Sujets: | |
| Accès en ligne: | https://pubmed.ncbi.nlm.nih.gov/41481803/ |
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| _version_ | 1868266105523404802 |
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| author | Chen, Liuhai Li, Changfen Li, Feng Chen, Zeping Fang, Runping Chen, Yingying Zhu, Hongjie Ju, Jianhua |
| author_facet | Chen, Liuhai Li, Changfen Li, Feng Chen, Zeping Fang, Runping Chen, Yingying Zhu, Hongjie Ju, Jianhua Chen, Liuhai Li, Changfen Li, Feng Chen, Zeping Fang, Runping Chen, Yingying Zhu, Hongjie Ju, Jianhua |
| collection | PubMed - marine biology |
| contents | Picolinic Acid Derivatives and Biosynthetic Pathway from SDU-F549. Chen, Liuhai Li, Changfen Li, Feng Chen, Zeping Fang, Runping Chen, Yingying Zhu, Hongjie Ju, Jianhua Picolinic Acids Humans Molecular Structure Ascomycota Anti-Bacterial Agents Microbial Sensitivity Tests Staphylococcus aureus Biosynthetic Pathways Drug Screening Assays, Antitumor Cell Line, Tumor Two new picolinic acid derivatives, ethylfusaric acid A () and ethylfusaric acid B (), along with two known picolinic acid derivatives (-), were isolated from the culture of endophytic fungus SDU-F549. The chemical structures of the compounds were elucidated by the combination of 1D and 2D nuclear magnetic resonance spectroscopy and electronic circular dichroism calculations. Compounds - exhibited antibacterial activity against a panel of strains, with MIC values ranging from 16 to 32 g/mL. In contrast, they showed no significant cytotoxic activity against a range of human tumor cell lines at 10 M. Furthermore, bioinformatic analysis revealed that the biosynthetic gene cluster in SDU-F549 is responsible for assembling the picolinic acid derivatives, enabling us to propose the biosynthetic pathways of compounds -. |
| format | Artículo científico |
| id | pubmed_41481803 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Journal of natural products |
| record_format | pubmed |
| spellingShingle | Picolinic Acid Derivatives and Biosynthetic Pathway from SDU-F549. Chen, Liuhai Li, Changfen Li, Feng Chen, Zeping Fang, Runping Chen, Yingying Zhu, Hongjie Ju, Jianhua Picolinic Acids Humans Molecular Structure Ascomycota Anti-Bacterial Agents Microbial Sensitivity Tests Staphylococcus aureus Biosynthetic Pathways Drug Screening Assays, Antitumor Cell Line, Tumor Picolinic Acid Derivatives and Biosynthetic Pathway from SDU-F549. Chen, Liuhai Li, Changfen Li, Feng Chen, Zeping Fang, Runping Chen, Yingying Zhu, Hongjie Ju, Jianhua Picolinic Acids Humans Molecular Structure Ascomycota Anti-Bacterial Agents Microbial Sensitivity Tests Staphylococcus aureus Biosynthetic Pathways Drug Screening Assays, Antitumor Cell Line, Tumor Two new picolinic acid derivatives, ethylfusaric acid A () and ethylfusaric acid B (), along with two known picolinic acid derivatives (-), were isolated from the culture of endophytic fungus SDU-F549. The chemical structures of the compounds were elucidated by the combination of 1D and 2D nuclear magnetic resonance spectroscopy and electronic circular dichroism calculations. Compounds - exhibited antibacterial activity against a panel of strains, with MIC values ranging from 16 to 32 g/mL. In contrast, they showed no significant cytotoxic activity against a range of human tumor cell lines at 10 M. Furthermore, bioinformatic analysis revealed that the biosynthetic gene cluster in SDU-F549 is responsible for assembling the picolinic acid derivatives, enabling us to propose the biosynthetic pathways of compounds -. |
| title | Picolinic Acid Derivatives and Biosynthetic Pathway from SDU-F549. |
| topic | Picolinic Acids Humans Molecular Structure Ascomycota Anti-Bacterial Agents Microbial Sensitivity Tests Staphylococcus aureus Biosynthetic Pathways Drug Screening Assays, Antitumor Cell Line, Tumor |
| url | https://pubmed.ncbi.nlm.nih.gov/41481803/ |