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| Autori principali: | , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Journal of natural products
2026
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/41481803/ |
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Sommario:
- Picolinic Acid Derivatives and Biosynthetic Pathway from SDU-F549. Chen, Liuhai Li, Changfen Li, Feng Chen, Zeping Fang, Runping Chen, Yingying Zhu, Hongjie Ju, Jianhua Picolinic Acids Humans Molecular Structure Ascomycota Anti-Bacterial Agents Microbial Sensitivity Tests Staphylococcus aureus Biosynthetic Pathways Drug Screening Assays, Antitumor Cell Line, Tumor Two new picolinic acid derivatives, ethylfusaric acid A () and ethylfusaric acid B (), along with two known picolinic acid derivatives (-), were isolated from the culture of endophytic fungus SDU-F549. The chemical structures of the compounds were elucidated by the combination of 1D and 2D nuclear magnetic resonance spectroscopy and electronic circular dichroism calculations. Compounds - exhibited antibacterial activity against a panel of strains, with MIC values ranging from 16 to 32 g/mL. In contrast, they showed no significant cytotoxic activity against a range of human tumor cell lines at 10 M. Furthermore, bioinformatic analysis revealed that the biosynthetic gene cluster in SDU-F549 is responsible for assembling the picolinic acid derivatives, enabling us to propose the biosynthetic pathways of compounds -.