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| Natura: | Artículo científico |
| Lingua: | en |
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PLoS biology
2026
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| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/41490069/ |
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| author | Vianello, Stefano Davide Lin, Ching-Yi Pinem, Wahyu Cristine Li, Han-Ru Li, Kun-Lung Sonia, Grace Lee, Shu-Hua Wu, Szu-Kai Laudet, Vincent Su, Yi-Hsien Yu, Jr-Kai Schneider, Stephan Q |
| author_facet | Vianello, Stefano Davide Lin, Ching-Yi Pinem, Wahyu Cristine Li, Han-Ru Li, Kun-Lung Sonia, Grace Lee, Shu-Hua Wu, Szu-Kai Laudet, Vincent Su, Yi-Hsien Yu, Jr-Kai Schneider, Stephan Q Vianello, Stefano Davide Lin, Ching-Yi Pinem, Wahyu Cristine Li, Han-Ru Li, Kun-Lung Sonia, Grace Lee, Shu-Hua Wu, Szu-Kai Laudet, Vincent Su, Yi-Hsien Yu, Jr-Kai Schneider, Stephan Q |
| collection | PubMed - marine biology |
| contents | Comparative transcriptomics reveal the common anteroposterior molecular blueprint of adult bilaterian guts. Vianello, Stefano Davide Lin, Ching-Yi Pinem, Wahyu Cristine Li, Han-Ru Li, Kun-Lung Sonia, Grace Lee, Shu-Hua Wu, Szu-Kai Laudet, Vincent Su, Yi-Hsien Yu, Jr-Kai Schneider, Stephan Q Animals Transcriptome Body Patterning Gene Expression Regulation, Developmental Transcription Factors Phylogeny Sea Urchins Gene Expression Profiling Gastrointestinal Tract Vertebrates Metamorphosis, Biological Larva A through-gut is one of the major features of bilaterians. Comparative work among bilaterians has identified common molecular mechanisms during early gut patterning, but the primordial gut later often undergoes different degrees of reorganization in each lineage to form a fully differentiated adult gut with specializations along its anteroposterior (AP) axis. Yet, how the conserved embryonic gut AP pattern relates to the adult guts in diverse bilaterians after metamorphosis is still poorly understood. To unravel the molecular subdivisions of adult guts, we investigated the gut through transcriptomic analyses of five phylogenetically informative species: an annelid, a sea urchin, a hemichordate, a cephalochordate, and a vertebrate. We identified bipartite transcriptional programs defining the AP functional subdivisions. Patterning systems composed of Hox, ParaHox, and, surprisingly, other transcription factors (TFs) known to be involved in gut formation in sea urchin larvae are maintained in these adult tissues. Using unbiased analyses, we identified five conserved TF modules corresponding to the AP compartments of the guts that are elaborated or shifted in different species. Our study inferred conserved and modified adult AP patterning modules along bilaterian guts enabling the reconstruction of ancestral bilaterian features with profound implications for the evolution of the bilaterian body plan. |
| format | Artículo científico |
| id | pubmed_41490069 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | PLoS biology |
| record_format | pubmed |
| spellingShingle | Comparative transcriptomics reveal the common anteroposterior molecular blueprint of adult bilaterian guts. Vianello, Stefano Davide Lin, Ching-Yi Pinem, Wahyu Cristine Li, Han-Ru Li, Kun-Lung Sonia, Grace Lee, Shu-Hua Wu, Szu-Kai Laudet, Vincent Su, Yi-Hsien Yu, Jr-Kai Schneider, Stephan Q Animals Transcriptome Body Patterning Gene Expression Regulation, Developmental Transcription Factors Phylogeny Sea Urchins Gene Expression Profiling Gastrointestinal Tract Vertebrates Metamorphosis, Biological Larva Comparative transcriptomics reveal the common anteroposterior molecular blueprint of adult bilaterian guts. Vianello, Stefano Davide Lin, Ching-Yi Pinem, Wahyu Cristine Li, Han-Ru Li, Kun-Lung Sonia, Grace Lee, Shu-Hua Wu, Szu-Kai Laudet, Vincent Su, Yi-Hsien Yu, Jr-Kai Schneider, Stephan Q Animals Transcriptome Body Patterning Gene Expression Regulation, Developmental Transcription Factors Phylogeny Sea Urchins Gene Expression Profiling Gastrointestinal Tract Vertebrates Metamorphosis, Biological Larva A through-gut is one of the major features of bilaterians. Comparative work among bilaterians has identified common molecular mechanisms during early gut patterning, but the primordial gut later often undergoes different degrees of reorganization in each lineage to form a fully differentiated adult gut with specializations along its anteroposterior (AP) axis. Yet, how the conserved embryonic gut AP pattern relates to the adult guts in diverse bilaterians after metamorphosis is still poorly understood. To unravel the molecular subdivisions of adult guts, we investigated the gut through transcriptomic analyses of five phylogenetically informative species: an annelid, a sea urchin, a hemichordate, a cephalochordate, and a vertebrate. We identified bipartite transcriptional programs defining the AP functional subdivisions. Patterning systems composed of Hox, ParaHox, and, surprisingly, other transcription factors (TFs) known to be involved in gut formation in sea urchin larvae are maintained in these adult tissues. Using unbiased analyses, we identified five conserved TF modules corresponding to the AP compartments of the guts that are elaborated or shifted in different species. Our study inferred conserved and modified adult AP patterning modules along bilaterian guts enabling the reconstruction of ancestral bilaterian features with profound implications for the evolution of the bilaterian body plan. |
| title | Comparative transcriptomics reveal the common anteroposterior molecular blueprint of adult bilaterian guts. |
| topic | Animals Transcriptome Body Patterning Gene Expression Regulation, Developmental Transcription Factors Phylogeny Sea Urchins Gene Expression Profiling Gastrointestinal Tract Vertebrates Metamorphosis, Biological Larva |
| url | https://pubmed.ncbi.nlm.nih.gov/41490069/ |