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| Main Authors: | , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Chemistry & biodiversity
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41504104/ |
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| _version_ | 1868266102689103872 |
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| author | Wang, Hao Li, Wen-Xuan Ru, Chao Gao, Zhen Li, Xu-Wen |
| author_facet | Wang, Hao Li, Wen-Xuan Ru, Chao Gao, Zhen Li, Xu-Wen Wang, Hao Li, Wen-Xuan Ru, Chao Gao, Zhen Li, Xu-Wen |
| collection | PubMed - marine biology |
| contents | Placidenes G-J, Bioactive γ-Pyrone Derivatives From the Marine Mollusk Placida dendritica. Wang, Hao Li, Wen-Xuan Ru, Chao Gao, Zhen Li, Xu-Wen Animals Pyrones Mice Nitric Oxide RAW 264.7 Cells Structure-Activity Relationship Molecular Structure Mollusca Stereoisomerism Molecular Conformation Three pairs of undescribed enantiomeric γ-pyrone derivatives placidenes G-I (1-3), together with two new congeners placidene J (4)/isoplacidene J (5) and two known compounds 6 and 7, were isolated from the marine mollusk Placida dendritica. Compounds 1a/1b-3a/3b were further separated by chiral-phase high-performance liquid chromatography. The structures were elucidated by comprehensive spectroscopic analysis, high-resolution electrospray ionization mass spectrometry, time-dependent density functional theory/electronic circular dichroism calculation, and X-ray diffraction analysis. In bioassays, compounds 1-5 exhibited moderate nitric oxide inhibition from 28.2% to 51.9% on RAW264.7 inflammatory cells at 20 µM without notable cytotoxicity. |
| format | Artículo científico |
| id | pubmed_41504104 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Chemistry & biodiversity |
| record_format | pubmed |
| spellingShingle | Placidenes G-J, Bioactive γ-Pyrone Derivatives From the Marine Mollusk Placida dendritica. Wang, Hao Li, Wen-Xuan Ru, Chao Gao, Zhen Li, Xu-Wen Animals Pyrones Mice Nitric Oxide RAW 264.7 Cells Structure-Activity Relationship Molecular Structure Mollusca Stereoisomerism Molecular Conformation Placidenes G-J, Bioactive γ-Pyrone Derivatives From the Marine Mollusk Placida dendritica. Wang, Hao Li, Wen-Xuan Ru, Chao Gao, Zhen Li, Xu-Wen Animals Pyrones Mice Nitric Oxide RAW 264.7 Cells Structure-Activity Relationship Molecular Structure Mollusca Stereoisomerism Molecular Conformation Three pairs of undescribed enantiomeric γ-pyrone derivatives placidenes G-I (1-3), together with two new congeners placidene J (4)/isoplacidene J (5) and two known compounds 6 and 7, were isolated from the marine mollusk Placida dendritica. Compounds 1a/1b-3a/3b were further separated by chiral-phase high-performance liquid chromatography. The structures were elucidated by comprehensive spectroscopic analysis, high-resolution electrospray ionization mass spectrometry, time-dependent density functional theory/electronic circular dichroism calculation, and X-ray diffraction analysis. In bioassays, compounds 1-5 exhibited moderate nitric oxide inhibition from 28.2% to 51.9% on RAW264.7 inflammatory cells at 20 µM without notable cytotoxicity. |
| title | Placidenes G-J, Bioactive γ-Pyrone Derivatives From the Marine Mollusk Placida dendritica. |
| topic | Animals Pyrones Mice Nitric Oxide RAW 264.7 Cells Structure-Activity Relationship Molecular Structure Mollusca Stereoisomerism Molecular Conformation |
| url | https://pubmed.ncbi.nlm.nih.gov/41504104/ |