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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Molecules (Basel, Switzerland)
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41515333/ |
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| _version_ | 1868266100251164672 |
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| author | Guzii, Alla G Kudryashova, Ekaterina K Shubina, Larisa K Makarieva, Tatyana N Menshov, Alexander S Popov, Roman S Yurchenko, Ekaterina A Pislyagin, Evgeny A Chingizova, Ekaterina A Grebnev, Boris B Shilov, Vladimir A Stonik, Valentin A |
| author_facet | Guzii, Alla G Kudryashova, Ekaterina K Shubina, Larisa K Makarieva, Tatyana N Menshov, Alexander S Popov, Roman S Yurchenko, Ekaterina A Pislyagin, Evgeny A Chingizova, Ekaterina A Grebnev, Boris B Shilov, Vladimir A Stonik, Valentin A Guzii, Alla G Kudryashova, Ekaterina K Shubina, Larisa K Makarieva, Tatyana N Menshov, Alexander S Popov, Roman S Yurchenko, Ekaterina A Pislyagin, Evgeny A Chingizova, Ekaterina A Grebnev, Boris B Shilov, Vladimir A Stonik, Valentin A |
| collection | PubMed - marine biology |
| contents | Anthonoic Acids A-C, Sulfated and -(2-Hydroxyethyl)-Substituted Lipidic Amino Acids from the Marine Sponge with In Vitro Cytoprotective Activities. Guzii, Alla G Kudryashova, Ekaterina K Shubina, Larisa K Makarieva, Tatyana N Menshov, Alexander S Popov, Roman S Yurchenko, Ekaterina A Pislyagin, Evgeny A Chingizova, Ekaterina A Grebnev, Boris B Shilov, Vladimir A Stonik, Valentin A Animals Porifera Amino Acids Humans Reactive Oxygen Species NF-E2-Related Factor 2 Cytoprotection Cell Line Receptors, Purinergic P2X7 Rats Anthonoic acids A-C (-), the first representatives of sulfated and -(2-hydroxyethyl)-substituted lipidic -amino acids, were isolated along with their plausible precursor, anthamino acid A (), from the marine sponge . The structures of these compounds were determined using the analysis of 1D and 2D NMR and HR ESI mass spectra. A structural feature of -, compared to all previously known lipidic amino acids, is the presence of a sulfate group near the end opposite the amino acid terminus. At a concentration of 1 µM, anthonoic acids A-C (-) effectively protected H9c2 and SH-SY5Y cells in biotests, which modeled hypoxia induced by the addition of CoCl to the medium and damage caused by ischemia/reperfusion. These natural products act via the Nrf2-mediated pathway by reducing intracellular ROS levels, accompanied by the upregulation of SOD activity, which is controlled by the Nrf2 transcriptional factor. Anthonoic acids A-C (-) do not activate the transcriptional activity of NF-B but inhibit ATP-induced cell damage and calcium influx, indicating the involvement of P2X7 receptors in the cytoprotective effect of anthonoic acids A-C. |
| format | Artículo científico |
| id | pubmed_41515333 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Molecules (Basel, Switzerland) |
| record_format | pubmed |
| spellingShingle | Anthonoic Acids A-C, Sulfated and -(2-Hydroxyethyl)-Substituted Lipidic Amino Acids from the Marine Sponge with In Vitro Cytoprotective Activities. Guzii, Alla G Kudryashova, Ekaterina K Shubina, Larisa K Makarieva, Tatyana N Menshov, Alexander S Popov, Roman S Yurchenko, Ekaterina A Pislyagin, Evgeny A Chingizova, Ekaterina A Grebnev, Boris B Shilov, Vladimir A Stonik, Valentin A Animals Porifera Amino Acids Humans Reactive Oxygen Species NF-E2-Related Factor 2 Cytoprotection Cell Line Receptors, Purinergic P2X7 Rats Anthonoic Acids A-C, Sulfated and -(2-Hydroxyethyl)-Substituted Lipidic Amino Acids from the Marine Sponge with In Vitro Cytoprotective Activities. Guzii, Alla G Kudryashova, Ekaterina K Shubina, Larisa K Makarieva, Tatyana N Menshov, Alexander S Popov, Roman S Yurchenko, Ekaterina A Pislyagin, Evgeny A Chingizova, Ekaterina A Grebnev, Boris B Shilov, Vladimir A Stonik, Valentin A Animals Porifera Amino Acids Humans Reactive Oxygen Species NF-E2-Related Factor 2 Cytoprotection Cell Line Receptors, Purinergic P2X7 Rats Anthonoic acids A-C (-), the first representatives of sulfated and -(2-hydroxyethyl)-substituted lipidic -amino acids, were isolated along with their plausible precursor, anthamino acid A (), from the marine sponge . The structures of these compounds were determined using the analysis of 1D and 2D NMR and HR ESI mass spectra. A structural feature of -, compared to all previously known lipidic amino acids, is the presence of a sulfate group near the end opposite the amino acid terminus. At a concentration of 1 µM, anthonoic acids A-C (-) effectively protected H9c2 and SH-SY5Y cells in biotests, which modeled hypoxia induced by the addition of CoCl to the medium and damage caused by ischemia/reperfusion. These natural products act via the Nrf2-mediated pathway by reducing intracellular ROS levels, accompanied by the upregulation of SOD activity, which is controlled by the Nrf2 transcriptional factor. Anthonoic acids A-C (-) do not activate the transcriptional activity of NF-B but inhibit ATP-induced cell damage and calcium influx, indicating the involvement of P2X7 receptors in the cytoprotective effect of anthonoic acids A-C. |
| title | Anthonoic Acids A-C, Sulfated and -(2-Hydroxyethyl)-Substituted Lipidic Amino Acids from the Marine Sponge with In Vitro Cytoprotective Activities. |
| topic | Animals Porifera Amino Acids Humans Reactive Oxygen Species NF-E2-Related Factor 2 Cytoprotection Cell Line Receptors, Purinergic P2X7 Rats |
| url | https://pubmed.ncbi.nlm.nih.gov/41515333/ |