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| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Molecules (Basel, Switzerland)
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41515371/ |
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| _version_ | 1868266100250116097 |
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| author | Oskoei, Párástu Afonso, Rúben Bastos, Verónica Nogueira, João Keller, Lisa-Marie Andresen, Elina Saleh, Maysoon I Rühle, Bastian Resch-Genger, Ute Daniel-da-Silva, Ana L Oliveira, Helena |
| author_facet | Oskoei, Párástu Afonso, Rúben Bastos, Verónica Nogueira, João Keller, Lisa-Marie Andresen, Elina Saleh, Maysoon I Rühle, Bastian Resch-Genger, Ute Daniel-da-Silva, Ana L Oliveira, Helena Oskoei, Párástu Afonso, Rúben Bastos, Verónica Nogueira, João Keller, Lisa-Marie Andresen, Elina Saleh, Maysoon I Rühle, Bastian Resch-Genger, Ute Daniel-da-Silva, Ana L Oliveira, Helena |
| collection | PubMed - marine biology |
| contents | Upconversion Nanoparticles with Mesoporous Silica Coatings for Doxorubicin Targeted Delivery to Melanoma Cells. Oskoei, Párástu Afonso, Rúben Bastos, Verónica Nogueira, João Keller, Lisa-Marie Andresen, Elina Saleh, Maysoon I Rühle, Bastian Resch-Genger, Ute Daniel-da-Silva, Ana L Oliveira, Helena Doxorubicin Silicon Dioxide Humans Nanoparticles Melanoma Porosity Cell Line, Tumor Folic Acid Drug Carriers Drug Delivery Systems Drug Liberation Animals Mice Melanoma is one of the most aggressive skin cancers and requires innovative therapeutic strategies to overcome the limitations of conventional therapies. In this work, upconversion nanoparticles coated with mesoporous silica and functionalized with folic acid (UCNP@mSiO-FA) were developed as a targeted nanocarrier system for the delivery of doxorubicin (DOX). The UCNPs were synthesized via thermal decomposition, coated with mesoporous silica shells, and functionalized with folic acid (FA) to enable receptor-mediated targeting. DOX was then loaded into the mesoporous silica coating by adsorption, yielding UCNP@mSiO-FA-DOX. The different UCNPs were characterized for size, composition, colloidal stability, and loading and release of DOX. This comprehensive physicochemical characterization confirmed a high DOX loading efficiency and a slightly increased drug release under acidic conditions, mimicking the tumour microenvironment. In vitro assays using four melanoma cell lines (A375, B16-F10, MNT-1, and SK-MEL-28) revealed an excellent biocompatibility of UCNP@mSiO-FA and a significantly higher cytotoxicity of UCNP@mSiO-FA-DOX compared to unloaded UCNPs, in a dose-dependent manner. Cell cycle analysis demonstrated G2/M phase arrest after treatment with UCNP@mSiO-FA-DOX, confirming its antiproliferative effect. Overall, UCNP@mSiO-FA-DOX represents a promising nanoplatform for targeted melanoma therapy, combining active tumour targeting and enhanced anticancer efficacy. |
| format | Artículo científico |
| id | pubmed_41515371 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Molecules (Basel, Switzerland) |
| record_format | pubmed |
| spellingShingle | Upconversion Nanoparticles with Mesoporous Silica Coatings for Doxorubicin Targeted Delivery to Melanoma Cells. Oskoei, Párástu Afonso, Rúben Bastos, Verónica Nogueira, João Keller, Lisa-Marie Andresen, Elina Saleh, Maysoon I Rühle, Bastian Resch-Genger, Ute Daniel-da-Silva, Ana L Oliveira, Helena Doxorubicin Silicon Dioxide Humans Nanoparticles Melanoma Porosity Cell Line, Tumor Folic Acid Drug Carriers Drug Delivery Systems Drug Liberation Animals Mice Upconversion Nanoparticles with Mesoporous Silica Coatings for Doxorubicin Targeted Delivery to Melanoma Cells. Oskoei, Párástu Afonso, Rúben Bastos, Verónica Nogueira, João Keller, Lisa-Marie Andresen, Elina Saleh, Maysoon I Rühle, Bastian Resch-Genger, Ute Daniel-da-Silva, Ana L Oliveira, Helena Doxorubicin Silicon Dioxide Humans Nanoparticles Melanoma Porosity Cell Line, Tumor Folic Acid Drug Carriers Drug Delivery Systems Drug Liberation Animals Mice Melanoma is one of the most aggressive skin cancers and requires innovative therapeutic strategies to overcome the limitations of conventional therapies. In this work, upconversion nanoparticles coated with mesoporous silica and functionalized with folic acid (UCNP@mSiO-FA) were developed as a targeted nanocarrier system for the delivery of doxorubicin (DOX). The UCNPs were synthesized via thermal decomposition, coated with mesoporous silica shells, and functionalized with folic acid (FA) to enable receptor-mediated targeting. DOX was then loaded into the mesoporous silica coating by adsorption, yielding UCNP@mSiO-FA-DOX. The different UCNPs were characterized for size, composition, colloidal stability, and loading and release of DOX. This comprehensive physicochemical characterization confirmed a high DOX loading efficiency and a slightly increased drug release under acidic conditions, mimicking the tumour microenvironment. In vitro assays using four melanoma cell lines (A375, B16-F10, MNT-1, and SK-MEL-28) revealed an excellent biocompatibility of UCNP@mSiO-FA and a significantly higher cytotoxicity of UCNP@mSiO-FA-DOX compared to unloaded UCNPs, in a dose-dependent manner. Cell cycle analysis demonstrated G2/M phase arrest after treatment with UCNP@mSiO-FA-DOX, confirming its antiproliferative effect. Overall, UCNP@mSiO-FA-DOX represents a promising nanoplatform for targeted melanoma therapy, combining active tumour targeting and enhanced anticancer efficacy. |
| title | Upconversion Nanoparticles with Mesoporous Silica Coatings for Doxorubicin Targeted Delivery to Melanoma Cells. |
| topic | Doxorubicin Silicon Dioxide Humans Nanoparticles Melanoma Porosity Cell Line, Tumor Folic Acid Drug Carriers Drug Delivery Systems Drug Liberation Animals Mice |
| url | https://pubmed.ncbi.nlm.nih.gov/41515371/ |